Asymptotic Analysis of Elliptic Membrane Shells in Thermoelastodynamics

In this paper we consider a family of three-dimensional problems in thermoelasticity for elliptic membrane shells and study the asymptotic behaviour of the solution when the thickness tends to zero. We fully characterize with strong convergence results the limit as the unique solution of a two-dimensional problem, where the reference domain is the common middle surface of the family of three-dimensional shells. The problems are dynamic and the constitutive thermoelastic law is given by the Duhamel-Neumann relation.Fil: Cao Rial, M. T.. Universidade da Coruña; EspañaFil: Castiñeira, G.. Universidad de Vigo; EspañaFil: Rodríguez Arós, Á.. Universidade da Coruña; EspañaFil: Roscani, Sabrina Dina. Universidad Austral. Facultad de Ciencias Empresariales. Departamento de Matemáticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentin

Adenine nucleotide translocase family: Four isoforms for apoptosis modulation in cancer

Mitochondria have important functions in mammalian cells as the energy powerhouse and integrators of the mitochondrial pathway of apoptosis. The adenine nucleotide translocase (ANT) is a family of proteins involved in cell death pathways that perform distinctly opposite functions to regulate cell fate decisions. On the one hand, ANT catalyzes the adenosine triphosphate export from the mitochondrial matrix to the intermembrane space with the concomitant import of ADP from the intermembrane space to the matrix. On the other hand, during periods of stress, ANT could function as a lethal pore and trigger the process of mitochondrial membrane permeabilization, which leads irreversibly to cell death. In human, ANT is encoded by four homologous genes, whose expression is not only tissue specific, but also varies according to the pathophysiological state of the cell. Recent evidence revealed a differential role of the ANT isoforms in apoptosis and a deregulation of their expression in cancer. In this review, we introduce the current knowledge of ANT in apoptosis and cancer cells and propose a novel classification of ANT isoforms. © 2011 Macmillan Publishers Limited All rights reserved