Design Challenges of Intra- and Inter- Chiplet Interconnection

In a chiplet-based many-core system, intra- and inter- chiplet interconnection is key to system performance and power consumption. There are a few challenges in intra- and inter- chiplet interconnection network: 1) Fast and accurate simulation is necessary to analyze the performance metrics. 2) Efficient network architecture for inter- and intra- chiplet is necessary, including topology, PHY design and deadlock free routing algorithms, etc. 3) Deep learning based AI systems are demanding more computation power, which calls for the need of efficient and low power chiplet-based systems. This paper proposes network designs to address these challenges and provides future research directions

The complete mitochondrial genome of a leaf roller, Eudemis lucina (Lepidoptera: Tortricidae)

The leaf roller, Eudemis lucina, is a potential pest of Quercus in East Asia. In this study, we described the complete mitochondrial genome of this species by high-throughput sequencing. The mitochondrial genome is found to be a circular molecule of 16,056 bp in length, which consisted of 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes, and a non-coding control region (A + T-rich region). The A + T content is 80.5% for the whole mitogenome. All PCGs are initiated by ATN codons, except for COI which is initiated by the CGA codon. Eight PCGs use a typical stop codon of TAA, whereas the remaining PCGs use incomplete stop codon of T–– or TA–. The non-coding control region is 1013 bp and located between s-rRNA and Met-tRNA

Nutrient and Isotopic Dynamics of Litter Decomposition from Different Land Uses in Naturally Restoring Taihang Mountain, North China

Litter decomposition is a prominent pathway for nutrient availability and management in terrestrial ecosystems. An in-situ litter decomposition experiment was carried out for different land use types along an elevation gradient in the Taihang Mountain area restored after heavy forest degradation in the past. Four land use types, i.e., cropland, shrubland, grassland, and forest, selected randomly from a 300–700 m elevation were investigated for the experiment using the litter bag technique. Litter mass loss ranged from 26.9% (forest) to 44.3% (cropland) varying significantly among land use types. The initial litter quality, mainly N and C/N, had a significant effect on the litter loss rate. The interaction of elevation × land use types × time was significant (p < 0.001). Litter nutrient mobility (K > P ≈ N > C) of the decomposing litter was sporadic with substantial stoichiometric effects of C/N, N/P, and C/P. The residual litters were enriched in 15N and depleted in 13C as compared to the initial litter. Increment of N, P, and δ15N values in residual litter indicates that, even in the highly weathered substrate, plant litter plays a crucial role in conserving nutrients. This study is a strong baseline for monitoring the functioning of the Taihang Mountain ecosystem restored after the complete destruction in the early 1990s

Gradual Stress-Relaxation of Hydrogel Regulates Cell Spreading

There is growing evidence that the mechanical properties of extracellular matrices (ECMs), including elasticity and stress-relaxation, greatly influence the function and form of the residing cells. However, the effects of elasticity and stress-relaxation are often correlated, making the study of the effect of stress-relaxation on cellular behaviors difficult. Here, we designed a hybrid network hydrogel with a controllable stress-relaxation gradient and a constant elasticity. The hydrogel is crosslinked by covalent bonds and dynamic peptide-metal ion coordination interactions. The stress-relaxation gradient is controlled by spatially controlling the coordination and covalent crosslinker ratios. The different parts of the hydrogel exhibit distinct stress-relaxation amplitudes but the have same stress-relaxation timescale. Based on this hydrogel, we investigate the influence of hydrogel stress-relaxation on cell spreading. Our results show that the spreading of cells is suppressed at an increasing stress-relaxation amplitude with a fixed elasticity and stress-relaxation timescale. Our study provides a universal route to tune the stress-relaxation of hydrogels without changing their components and elasticity, which may be valuable for systematic investigations of the stress-relaxation gradient in cell cultures and organoid constructions

Regulations of cloudiness on energy partitioning and water use strategy in a riparian poplar plantation

Cloudiness is an important environmental variable that affects the total and proportion of diffuse radiation reaching the ground and thereby the rate of plant carbon assimilation. However, its regulations on ecosystem energy partitioning and water use strategy are not well understood, particularly for riparian ecosystems. We used the eddy covariance technique and micrometeorological sensors to measure the energy fluxes and environmental conditions for a poplar plantation adjacent to the Chaobai River in North China during the growing seasons (April–October) in 2014 and 2015. We found that canopy conductance (Gs) was the primary biophysical factor regulating the ecosystem energy partitioning, while vapor pressure deficit (VPD) did not impose significant effects on evaporative fraction (EF). Cloudiness suppressed EF primarily due to the stomatal closure caused by the decrease in direct radiation (Rdir). Furthermore, the ratio of stomatal sensitivity (m) and reference conductance (Gsref) was 0.36 and 0.48 mol m−2 s−1 ln(kPa)−1 during clear sky and cloudy sky conditions, respectively. These results indicated that this poplar plantation with an anisohydric behavior weakened stomatal control on water loss under clear skies by avoiding leaf burn arising from higher direct sunlight and temperature. Finally, the mean Priestley–Taylor coefficient (α) and EF was 1.01 and 0.61 across two growth periods, respectively, and ecosystem evapotranspiration (ET) exceeded rainfall, even in rainy year, suggesting that a certain amount of groundwater might be consumed by this riparian poplar plantation, which would exacerbate regional drought

The influence of social comparison on risk decision-making for self and groups in intergroup contexts

Objective The current study aims to explore the influence of social comparison on risk decision-making for self and for groups in intergroup contexts. Method Two experiments with the within-subjects design of 2 (social comparison: upward comparison, downward comparison) × 3 (decision-maker role: for “me”, for “us”, for “them”) were conducted in this study. Experiment 1 focused on the ingroup contexts, and experiment 2 focused on the outgroup contexts. Results (1) in outgroup contexts, individuals are more risk-seeking in upward comparison conditions than in downward comparison conditions. However, the difference disappears in ingroup contexts. (2) Making decisions for “them” is riskier than making decisions for “me” and for “us” with no significant differences between the latter two and consistent across intergroup contexts. (3) The difference in risk decisions made amid upward and downward comparisons is amplified for decisions made for groups. Conclusion The findings may support the selective accessibility model and provide an interpretation with responsibility alleviation for self-group differences in risk decision-making

Proteomic Analysis of Human Brain Microvascular Endothelial Cells Reveals Differential Protein Expression in Response to Enterovirus 71 Infection

2D DIGE technology was employed on proteins prepared from human brain microvascular endothelial cells (HBMEC), to study the differentially expressed proteins in cells at 0 h, 1 h, 16 h, and 24 h after infection. Proteins found to be differentially expressed were identified with matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry (MALDITOF/TOF MS) analysis. We identified 43 spots showing changes of at least 2.5 fold up- or downregulated expressions in EV71-infected cells at different time when comparing to control, and 28 proteins could be successfully identified by MALDI TOF/TOF mass spectrometry analysis. 4 proteins were significantly upregulated, and 6 proteins were downregulated, another 18 proteins were different expression at different incubation time. We identified changes in the expression of 12 cellular metabolism-related proteins, 5 molecules involved in cytoskeleton, 3 molecules involved in energy metabolism, 2 molecules involved in signal transduction, 1 molecule involved in the ubiquitin-proteasome pathway, 1 molecule involved in cell cycle, 1 molecule involved in apoptosis-related protein, 1 molecular chaperone, and 2 unknown proteins. These findings build up a comprehensive profile of the HBMEC proteome and provide a useful basis for further analysis of the pathogenic mechanism that underlies EV71 infections to induce severe neural complications

Strong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres

Abstract Hydrogels are promising soft materials as tissue engineering scaffolds, stretchable sensors, and soft robotics. Yet, it remains challenging to develop synthetic hydrogels with mechanical stability and durability similar to those of the connective tissues. Many of the necessary mechanical properties, such as high strength, high toughness, rapid recovery, and high fatigue resistance, generally cannot be established together using conventional polymer networks. Here we present a type of hydrogels comprising hierarchical structures of picot fibres made of copper-bound self-assembling peptide strands with zipped flexible hidden length. The redundant hidden lengths allow the fibres to be extended to dissipate mechanical load without reducing network connectivity, making the hydrogels robust against damage. The hydrogels possess high strength, good toughness, high fatigue threshold, and rapid recovery, comparable to or even outperforming those of articular cartilage. Our study highlights the unique possibility of tailoring hydrogel network structures at the molecular level to improve their mechanical performance