Mobile Game Application: The MagicTale

Many smartphone games today consist of players making simple and repetitive actions with their fingers to play the game. Compared to traditional PC Role Playing games (RPG), current mobile games do not provide the same fictional aspects and complex components. Players creativity is almost non-existent in most simple mobile application games. To address this issue, we propose to create a IOS mobile application game which combines the complex components of traditional PC RPGs and touch screen actions of mobile games

The Derived Equivalent Circuit Model for Magnetized Anisotropic Graphene

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Polarization-Engineering in III-V Nitride Heterostructures: New Opportunities For Device Design

The role of spontaneous and piezoelectric polarization in III-V nitride heterostructure devices is discussed. Problems as well as opportunities in incorporating polarization in abrupt and graded heterojunctions composed of binary, ternary, and quaternary nitrides are outlined.Comment: 7 pages, 5 figure

Drinfeld twists of the open XXZ chain with non-diagonal boundary terms

The Drinfeld twists or factorizing F-matrices for the open XXZ spin chain with non-diagonal boundary terms are constructed. It is shown that in the F-basis the two sets of pseudo-particle creation operators simultaneously take completely symmetric and polarization free form. The explicit and completely symmetric expressions of the two sets of Bethe states of the model are obtained.Comment: Latex file, 25 page

The mechanisms of Chansu in inducing efficient apoptosis in colon cancer cells

Chansu is one of the most widely used traditional Chinese medicines in China, Japan, and other Southeast Asian countries primarily for antipain, anti-inflammation, and recently anticancer. Over 10 recipes and remedies contained Chansu, which are easily available in pharmacies and hospitals, but the mechanisms of action were not clearly articulated. In the present study, Cinobufagin (CBF), the major compound of Chansu, was employed as a surrogate marker to determine its ability in inducing cancer cell death. As expected, CBF has significant cancer-killing capacity for a range of cancers, but such ability differs markedly. Colon and prostate cancers are more sensitive than skin and lung cancers. Interestingly, cancer cells die through apoptotic pathway either being biphasic caspase- 3-dependent (HCT116) or independent (HT29). Multipathway analysis reveals that CBF-induced apoptosis is likely modulated by the hypoxia-inducing factor-1 alpha subunit (HIF-

Urban sustainability indicators re-visited: Lessons from property-led urban development in China

This paper proposes a bespoke urban sustainability indicator framework in the context of China's prevalent property-led urban development. Emphasising local characteristics and incorporating underlying institutions, it advocates a more nuanced, holistic and dynamic approach when addressing sustainability issues. Selection of indicators were based on extensive literature reviews and tested through an international expert survey comprising both China-based and overseas-based experts. The two groups of experts have shown divergent views, with the former prioritizing economic and institutional aspects over environmental and social factors. It also provides transferable policy insights to developing countries more generally, given many similarities in broader development challenges. Discussion on recent literature and urban development reinforces the applicability of these tailor-made indicators to not only monitoring but also explaining and predicting urban changes. We argue it is necessary to recognize the centrality of property-led urban development in urban sustainable development, and the need for examining the complex relations between the property sector and urban sustainability via inclusion of institutional analysis and a multi-method approach combining quantitative and qualitative evaluations

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity. Caspase activity can also have a variety of unwanted consequences that include DNA damage. We therefore investigated whether MOMP-induced caspase-independent cell death (CICD) might be a better way to kill cancer cells. We find that cells undergoing CICD display potent pro-inflammatory effects relative to apoptosis. Underlying this, MOMP was found to stimulate NF-κB activity through the downregulation of inhibitor of apoptosis proteins. Strikingly, engagement of CICD displays potent anti-tumorigenic effects, often promoting complete tumour regression in a manner dependent on intact immunity. Our data demonstrate that by activating NF-κB, MOMP can exert additional signalling functions besides triggering cell death. Moreover, they support a rationale for engaging caspase-independent cell death in cell-killing anti-cancer therapies