Ectopic overexpression of the cell wall invertase gene CIN1 leads to dehydration avoidance in tomato

Drought stress conditions modify source–sink relations, thereby influencing plant growth, adaptive responses, and consequently crop yield. Invertases are key metabolic enzymes regulating sink activity through the hydrolytic cleavage of sucrose into hexose monomers, thus playing a crucial role in plant growth and development. However, the physiological role of invertases during adaptation to abiotic stress conditions is not yet fully understood. Here it is shown that plant adaptation to drought stress can be markedly improved in tomato (Solanum lycopersicum L.) by overexpression of the cell wall invertase (cwInv) gene CIN1 from Chenopodium rubrum. CIN1 overexpression limited stomatal conductance under normal watering regimes, leading to reduced water consumption during the drought period, while photosynthetic activity was maintained. This caused a strong increase in water use efficiency (up to 50%), markedly improving water stress adaptation through an efficient physiological strategy of dehydration avoidance. Drought stress strongly reduced cwInv activity and induced its proteinaceous inhibitor in the leaves of the wild-type plants. However, the CIN1-overexpressing plants registered 3- to 6-fold higher cwInv activity in all analysed conditions. Surprisingly, the enhanced invertase activity did not result in increased hexose concentrations due to the activation of the metabolic carbohydrate fluxes, as reflected by the maintenance of the activity of key enzymes of primary metabolism and increased levels of sugar-phosphate intermediates under water deprivation. The induced sink metabolism in the leaves explained the maintenance of photosynthetic activity, delayed senescence, and increased source activity under drought stress. Moreover, CIN1 plants also presented a better control of production of reactive oxygen species and sustained membrane protection. Those metabolic changes conferred by CIN1 overexpression were accompanied by increases in the concentrations of the senescence-delaying hormone trans-zeatin and decreases in the senescence-inducing ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) in the leaves. Thus, cwInv critically functions at the integration point of metabolic, hormonal, and stress signals, providing a novel strategy to overcome drought-induced limitations to crop yield, without negatively affecting plant fitness under optimal growth conditions.España Ministerio de Ciencia e Innovación AT2009-0038 and AGL2011-2799

ALGUNAS REFLEXIONES SOBRE LA ENSEÑANZA DE LA HISTORIA EN ENFERMERÍA.

The opinion standing for the uselessness of historic knowledge equals to state the irrelevance of Humanistic Sciences related to the advances of Humanity and Nursing. This myth could be shown by the consideration of the subject ‘History of Nursing’ as a ‘soft’ subject compared with others. This would take us to identify the economical-technical usefulness with progress, to the detriment of others areas of knowledge which cover different utility criteria. Consequently, the interest shown by Nursing students and their environment (family, friends, partners) towards historic knowledge is an important matter for the professional Nursing development as an intellectual speculative discipline. Our first investigation hypothesis attempts to prove this sociocultural happening within a sample of students from first to third year of their Degree in Nursing, matriculated at the Nursing Schools of the University of Murcia. We developed a descriptive research by the use of a written questionnaire which inquired about personal data of the own students and their relatives (sex, age, grade of studies, etc…) and by an assessment of the subjects from the study program according to the importance found to their education as future nurses. It was completed during February 2003, under participating observation.La opinión de que el conocimiento histórico no es útil (1) equivale a la irrelevancia de las ciencias humanísticas con relación al avance de la humanidad y de la Enfermería. Este paradigma explicativo se reflejaría en la consideración académica de la asignatura Historia de la Enfermería como una asignatura “blanda” frente a otras de carácter técnico-clínico-instrumental. Lo que nos llevaría a identificar lo útil económico-técnico con el progreso, en detrimento de otras áreas de conocimiento que responden a otros criterios de utilidad (1,2,3). Consecuentemente, la consideración prestada por el alumno de Enfermería y su entorno cercano (familia, amigos, compañeros) al conocimiento histórico es un factor importante en el desarrollo de la profesión enfermera como una disciplina intelectual y, por ende, con dimensión especulativa. Nuestra hipótesis primera de investigación intenta mostrar este fenómeno sociocultural en una muestra de alumnos/as de la Diplomatura de Enfermería, matriculados en la Universidad de Murcia, determinando el grado de importancia relativa asignado por los alumnos a la asignatura Historia de la Enfermería

UNA EXPLICACIÓN ANTROPOLÓGICA DEL EMBARAZO EN ADOLESCENTES EN LA COMARCA DEL MAR MENOR Y CAMPO DE CARTAGENA.

Introducción: El cambio en la regulación social de la sexualidad y el cambio producido en la conducta sexual y reproductiva de los jóvenes y sus posibles consecuencias están siendo los factores que más están influyendo en la conceptualización de los adolescentes como un grupo de riesgo por la sociedad y sus conductas como problema. Objetivos Objetivo general: Analizar la influencia de la cultura en la aceptación social y familiar de determinadas conductas relacionadas con el embarazo y parto en jóvenes. Objetivos específicos: 1º.- Conocer el nivel de instrucción de las puérperas menores de veinte años del Área de Salud II de la C.A.R.M. 2º.- Conocer su nivel socioeconómico. 3º.- Conocer la información sobre sexualidad y anticoncepción que poseen. 4º.- Conocer las fuentes de información de que disponen. Material y método: Para dar respuesta a estos interrogantes realizamos un estudio de prevalencia en la población de puérperas de 20 años o menos, que han dado a luz en los hospitales del Área de Salud II de la C.A.R.M., durante los meses de julio a octubre de 1995. Para comparar se elige un grupo control determinado por mujeres que dan a luz durante los mismos dias y en el mismo centro, mayores de 20 años y que no estén en la misma habitación, escogiendo de forma aleatoria a 2 puérperas mayores de 20 años por cada una de las menores (n=132). Se ha efectuado una encuesta para conocer el nivel de instrucción y el nivel socioeconómico de las puérperas en el momento de conocer su embarazo, así como la información que poseen sobre sexualidad y anticoncepción, y las fuentes de esa información. En esta encuesta se establecieron las variables que conforman la medida del nivel socioeconómico. Se ha llevado a cabo un estudio descriptivo de las distintas variables y sus asociaciones, evaluando las diferencias entre el grupo de las jóvenes y el de las adultas, en relación al lugar de residencia, estado civil, nivel de instrucción, nivel socioeconómico, grado de conocimientos, fuentes de información e influencia de las campañas públicas sobre sexualidad y anticoncepción. Hemos realizado un analisis univariante o distribución simple de frecuencias, observando las distribuciones de frecuencias absolutas y relativas en porcentajes para las variables cualitativas y para las variables cuantitativas la media y la desviación típica. Se estudio la diferencia de medias y desviación típica de algunas variables, calculando la "t de Student". Resultados y conclusiones: 1. La mayoría de las puérperas adolescentes, así como sus padres, tienen un nivel de instrucción bajo o son analfabetas, están adscritas a grupos económicos bajo o medio-bajo y presentan un nivel de cualificación profesional mínimo, por lo que podemos concluir que pertenecen a un grupo socioeconómico desfavorecido. 2. La mayoría de las jóvenes no planifica su embarazo ( 65'9%) y de éstas la mayoría no usa métodos anticonceptivos o no los conoce (65'5%). El preservativo y la marcha atrás son los métodos más utilizados. Destacamos que el 34'1% de las adolescentes planificó su embarazo. 3. Cuando aumenta la edad de la mujer, el nivel de estudios y el grupo económico, aumenta el conocimiento sobre sexualidad y anticoncepción. La principal fuente de información es el medio social. 4. Aunque el desconocimiento sobre las campañas publicitarias y charlas sobre sexualidad y anticoncepción es mayoritario para los dos grupos, se acentúa cuando la mujer es menor de veinte años, pertenece a un grupo económico bajo y tiene un nivel de instrucción bajo. En amplias zonas rurales del Campo de Cartagena en tiempos no muy lejanos, el llevarse a la novia ha sido aceptado e incluso provocado por motivos económicos. En la actualidad, ésta es una opción que ya ha caído en desuso (a medida que los niveles de instrucción y económicos han ido elevándose, prevalece más el deseo paterno de que las hijas consigan por sus medios un porvenir independiente), sin embargo, sí ha dejado en el acervo popular la aceptación de éste hecho como algo, si no recomendable, cuando menos no demasiado reprobable

Search for a light charged Higgs boson in t -> H±b decays, with H± -> cb, in the lepton plus jets final state in proton-proton collisions at root s=13 TeV with the ATLAS detector

A search for a charged Higgs boson, H-+/-, produced in top-quark decays, t -> H(+/-)b, is presented. The search targets H-+/- decays into a bottom and a charm quark, H-+/- -> cb. The analysis focuses on a selection enriched in top-quark pair production, where one top quark decays into a leptonically decaying W boson and a bottom quark, and the other top quark decays into a charged Higgs boson and a bottom quark. This topology leads to a lepton-plus-jets final state, characterised by an isolated electron or muon and at least four jets. The search exploits the high multiplicity of jets containing b-hadrons, and deploys a neural network classifier that uses the kinematic differences between the signal and the background. The search uses a dataset of proton-proton collisions collected at a centre-of-mass energy root s = 13TeV between 2015 and 2018 with the ATLAS detector at CERN's Large Hadron Collider, amounting to an integrated luminosity of 139 fb(-1). Observed (expected) 95% confidence-level upper limits between 0.15% (0.09%) and 0.42% (0.25%) are derived for the product of branching fractions B( t -> H-+/- b) x B( H +/- -> cb) for charged Higgs boson masses between 60 and 160 GeV, assuming the SM production of the top-quark pairs

Combined Measurement of the Higgs Boson Mass from the Formula Presented and Formula Presented Decay Channels with the ATLAS Detector Using Formula Presented, 8, and 13 TeV Formula Presented Collision Data

A measurement of the mass of the Higgs boson combining the Formula Presented and Formula Presented decay channels is presented. The result is based on Formula Presented of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of Formula Presented. This corresponds to a 0.09% precision achieved on this fundamental parameter of the Standard Model of particle physics

Test of CP Invariance in Higgs Boson Vector-Boson-Fusion Production Using the H→γγ Channel with the ATLAS Detector

A test of CP invariance in Higgs boson production via vector-boson fusion has been performed in the H→γγ channel using 139  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV collected by the ATLAS detector at the LHC. The optimal observable method is used to probe the CP structure of interactions between the Higgs boson and electroweak gauge bosons, as described by an effective field theory. No sign of CP violation is observed in the data. Constraints are set on the parameters describing the strength of the CP-odd component in the coupling between the Higgs boson and the electroweak gauge bosons in two effective field theory bases: d[over ˜] in the HISZ basis and c_{HW[over ˜]} in the Warsaw basis. The results presented are the most stringent constraints on CP violation in the coupling between Higgs and weak bosons. The 95% C.L. constraint on d[over ˜] is derived for the first time and the 95% C.L. constraint on c_{HW[over ˜]} has been improved by a factor of 5 compared to the previous measurement

Search for nonresonant pair production of Higgs bosons in the Formula Presented final state in pp collisions at Formula Presented with the ATLAS detector

A search for nonresonant Higgs boson pair production in the Formula Presented final state is presented. The analysis uses Formula Presented of Formula Presented collision data at Formula Presented collected with the ATLAS detector at the Large Hadron Collider, and targets both the gluon-gluon fusion and vector-boson fusion production modes. No evidence of the signal is found and the observed (expected) upper limit on the cross section for nonresonant Higgs boson pair production is determined to be 5.4 (8.1) times the Standard Model predicted cross section at 95% confidence level. Constraints are placed on modifiers to the Formula Presented and Formula Presented couplings. The observed (expected) Formula Presented constraints on the Formula Presented coupling modifier, Formula Presented, are determined to be Formula Presented (Formula Presented), while the corresponding constraints for the Formula Presented coupling modifier, Formula Presented, are Formula Presented (Formula Presented). In addition, constraints on relevant coefficients are derived in the context of the Standard Model effective field theory and Higgs effective field theory, and upper limits on the Formula Presented production cross section are placed in seven Higgs effective field theory benchmark scenarios

Observation of the γγ→ττ Process in Pb+Pb Collisions and Constraints on the τ-Lepton Anomalous Magnetic Moment with the ATLAS Detector

This Letter reports the observation of τ-lepton-pair production in ultraperipheral lead-lead collisions Pb+Pb→Pb(γγ→ττ)Pb and constraints on the τ-lepton anomalous magnetic moment a_{τ}. The dataset corresponds to an integrated luminosity of 1.44  nb^{-1} of LHC Pb+Pb collisions at sqrt[s_{NN}]=5.02  TeV recorded by the ATLAS experiment in 2018. Selected events contain one muon from a τ-lepton decay, an electron or charged-particle track(s) from the other τ-lepton decay, little additional central-detector activity, and no forward neutrons. The γγ→ττ process is observed in Pb+Pb collisions with a significance exceeding 5 standard deviations and a signal strength of μ_{ττ}=1.03_{-0.05}^{+0.06} assuming the standard model value for a_{τ}. To measure a_{τ}, a template fit to the muon transverse-momentum distribution from τ-lepton candidates is performed, using a dimuon (γγ→μμ) control sample to constrain systematic uncertainties. The observed 95% confidence-level interval for a_{τ} is -0.057<a_{τ}<0.024

Search for flavour-changing neutral tqH interactions with H -> gamma gamma in pp collisions at root s=13 TeV using the ATLAS detector

A search for flavour-changing neutral interactions involving the top quark, the Higgs boson and an up-type quark q ( q = c, u) is presented. The proton-proton collision data set used, with an integrated luminosity of 139 fb(-1), was collected at root s = 13TeV by the ATLAS experiment at the Large Hadron Collider. Both the decay process t -> qH in tt production and the production process pp. tH, with the Higgs boson decaying into two photons, are investigated. No significant excess is observed and upper limits are set on the t. cH and the t. uH branching ratios of 4.3x10(-4) and 3.8x10(-4), respectively, at the 95% confidence level, while the expected limits in the absence of signal are 4.7x10(-4) and 3.9x10(-4). Combining this search with ATLAS searches in the H. t+ t- and H. b b final states yields observed (expected) upper limits on the t -> cH branching ratio of 5.8 x 10(-4) (3.0 x 10(-4)) at the 95% confidence level. The corresponding observed (expected) upper limit on the t -> uH branching ratio is 4.0 x 10(-4) (2.4 x 10(-4))

Observation of an Excess of Dicharmonium Events in the Four-Muon Final State with the ATLAS Detector

A search is made for potential ccc[over ¯]c[over ¯] tetraquarks decaying into a pair of charmonium states in the four muon final state using proton-proton collision data at sqrt[s]=13  TeV, corresponding to an integrated luminosity of 140  fb^{-1} recorded by the ATLAS experiment at LHC. Two decay channels, J/ψ+J/ψ→4μ and J/ψ+ψ(2S)→4μ, are studied. Backgrounds are estimated based on a hybrid approach involving Monte Carlo simulations and data-driven methods. Statistically significant excesses with respect to backgrounds dominated by the single parton scattering are seen in the di-J/ψ channel consistent with a narrow resonance at 6.9 GeV and a broader structure at lower mass. A statistically significant excess is also seen in the J/ψ+ψ(2S) channel. The fitted masses and decay widths of the structures are reported