Photovoltaic energy competitiveness and risk assessment for the South African residential sector

The establishment of new photovoltaic (PV) markets in emerging economies represents a business development opportunity for expansion outside traditional energy markets. Appropriate assessment of PV market competitiveness is thus necessary in order to inform policy and regulatory development, and in order to manage risks related to investment. This paper presents an evaluation of PV energy competitiveness using a case study of the emerging residential PV market in South Africa. Competitiveness is defined in light of the risks associated with the financial performance of domestic grid-connected rooftop PV considering the current market status together with three proposed business models, namely net-metering, net-billing, and an energy savings performance contract framework. Financial performance is evaluated in terms of a socket parity evaluation together with a discounted net cash flow analysis. Investment risk assessment was facilitated using a Monte Carlo simulation. The results indicate the highest potential profitability for the energy savings performance contract model, which includes PV system ownership by an energy services company. It is also shown that appropriate application of risk modelling has the potential to inform decisions by investors and policy makers alike that result in improved policy and business solutions that are able to support increased residential PV energy market competitiveness without the need for explicit subsidy frameworks

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Bone healing at bicortically installed implants with different surface configurations. An experimental study in rabbits

OBJECTIVE To study the sequential healing at bicortically installed implants with surface modifications by the use of fluoroboric acid and/or H2 O2 . MATERIAL AND METHODS Twenty-eight albino New Zealand rabbits were used. Two recipient sites were prepared in the tibiae bilaterally, one in the metaphysis and the second in the diaphysis regions. Four implants with different surface characteristics were randomly installed with bicortical stabilization: (i) sandblasted and acid-etched; (ii) same surface as i, but with a substitution of the hydrofluoric acid with fluoroboric acid; (iii) same surface as i, additionally treated with H2 O2 ; and (iv) same surface modified as ii, additionally treated with H2 O2 . The animals were killed after 5, 8, 15, and 30 days. Ground sections were prepared for histological analyses. RESULTS No statistically significant differences in osseointegration were found among various surfaces at any of the healing periods. A higher degree of osseointegration was observed at the implants placed in the metaphysis compared to those placed in the diaphysis, especially during early healing. A higher degree of osseointegration was found at sites with proximity to compact (cortical) bone when compared to the middle portion of the implants, especially in the diaphysis region. CONCLUSIONS Surfaces modified with different acids or H2 O2 resulted in similar osseointegration compared to a standard sandblasted and acid-etched surface. The portion of the bicortically installed implants in close contact with the cortical compartment presented a higher percentage of osseointegration compared with the region in contact with the bone marrow compartment

Synthesis of a Structural Analogue of the Repeating Unit from Streptococcus pneumoniae 19F Capsular Polysaccharide Based on the Cross-Metathesis-Selenocyclization Reaction Sequence

Pseudo-oligosaccharides have attracted much interest as scaffolds for the synthesis of sugar mimics endowed with very similar biological properties but structurally and synthetically simpler than their natural counterparts. Herein, the synthesis of pseudo-oligosaccharides using the cross-metathesis reaction between distinct sugar-olefins followed by intramolecular selenocyclization of the obtained heterodimer as key steps is first investigated. This methodology has been then applied to the preparation of structural analogues of the trisaccharide repeating unit from Streptococcus pneumoniae 19F. The inhibition abilities of the synthetic molecules were evaluated by a competitive ELISA assay using a rabbit polyclonal anti-19F seru

Atelier « Pour un musée populaire et participatif à Saint-Denis (Seine-Saint-Denis) »

Ce projet d’atelier propose de construire un espace de sensibilisation et d’échanges entre la communauté universitaire et les habitants de Seine-Saint-Denis sur les “musées populaires”. Dans un premier temps, nous souhaitons présenter quelques expériences de “musées populaires” dans le monde, à partir de la Socio-muséologie et de la Muséologie Sociale au Brésil (“musées communautaires”), au Portugal, en Belgique et en France (les “éco-musées”). Dans un deuxième temps, nous proposons de constituer des ateliers d’expérience participative pour construire un projet de Musée Populaire en Seine-Saint-Denis, et notamment avec les habitants de la ville de Saint-Denis. Ce projet de musée populaire doit être conçu avec les habitants du territoire (territoire du campus Condorcet), à partir des perspectives de patrimoine et de mémoire qui seront exposées – et échangées – dans le cadre des rencontres de l’atelier.Les muséologies insurgées: échanges transnationaux11. Sustainable cities and communities10. Reduced inequalities16. Peace, justice and strong institution

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by 1H HR-MAS NMR Metabolomics

Multiple myeloma (MM) is a malignancy of plasma cells characterized by multifocal osteolytic bone lesions. Macroscopic and genetic heterogeneity has been documented within MM lesions. Understanding the bases of such heterogeneity may unveil relevant features of MM pathobiology. To this aim, we deployed unbiased 1H high-resolution magic-angle spinning (HR-MAS) nuclear magnetic resonance (NMR) metabolomics to analyze multiple biopsy specimens of osteolytic lesions from one case of pathological fracture caused by MM. Multivariate analyses on normalized metabolite peak integrals allowed clusterization of samples in accordance with a posteriori histological findings. We investigated the relationship between morphological and NMR features by merging morphological data and metabolite profiling into a single correlation matrix. Data-merging addressed tissue heterogeneity, and greatly facilitated the mapping of lesions and nearby healthy tissues. Our proof-of-principle study reveals integrated metabolomics and histomorphology as a promising approach for the targeted study of osteolytic lesions