5 research outputs found
ΠΠ°ΡΠ°Π΄ΠΈΠ³ΠΌΠ° ΡΡΠΈΠ΄ΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠ·ΠΈΠΊΡ Π² ΡΠΈΡΡΠ΅ΠΌΡ Π½Π°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΡ Π±Π΅Π·ΠΏΠ΅ΠΊΠΈ Π£ΠΊΡΠ°ΡΠ½ΠΈ (ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΠΈΠΉ Π°ΡΠΏΠ΅ΠΊΡ)
Π ΠΎΠ·Π³Π»ΡΠ΄Π°ΡΡΡΡΡ Π·Π°Π³Π°Π»ΡΠ½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠΈΡΡΠ΅ΠΌΠΈ Π½Π°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΡ Π±Π΅Π·ΠΏΠ΅ΠΊΠΈ. ΠΠΈΠ·Π½Π°ΡΠ°ΡΡΡΡΡ ΠΌΡΡΡΠ΅
ΡΠ° ΡΠΎΠ»Ρ ΡΡΠΈΠ΄ΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠ·ΠΈΠΊΡ Π² ΡΡΠ½ΠΊΡΡΠΎΠ½ΡΠ²Π°Π½Π½Ρ ΡΠΈΡΡΠ΅ΠΌΠΈ Π½Π°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΡ Π±Π΅Π·ΠΏΠ΅ΠΊΠΈ.
ΠΠ½Π°Π»ΡΠ·ΡΡΡΡΡΡ ΠΊΠ°ΡΠ΅Π³ΠΎΡΡΡ Β«ΡΡΠΈΠ΄ΠΈΡΠ½ΠΈΠΉ ΡΠΈΠ·ΠΈΠΊΒ» ΡΠ° ΠΉΠΎΠ³ΠΎ ΠΎΡΠ½ΠΎΠ²Π½Ρ ΡΠΊΠ»Π°Π΄ΠΎΠ²Ρ, ΡΠΌΠΎΠ²ΠΈ Π²ΠΈΠ½ΠΈΠΊΠ½Π΅Π½Π½Ρ ΡΠ° ΡΡΠ½ΠΊΡΡΠΎΠ½ΡΠ²Π°Π½Π½Ρ. ΠΡΠΎΠΏΠΎΠ½ΡΡΡΡΡΡ ΡΠΌΠΎΠ²ΠΈ ΠΏΡΠΎΡΠΈΠ΄ΡΡ ΡΠΈΠ·ΠΈΠΊΠ°ΠΌ ΡΠ° ΠΏΠΎΠ΄Π°ΡΡΡΡΡ ΠΌΠΎΠ΄Π΅Π»Ρ
Π·Π½ΠΈΠΆΠ΅Π½Π½Ρ ΡΡΠΈΠ΄ΠΈΡΠ½ΠΈΡ
ΡΠΈΠ·ΠΈΠΊΡΠ² Ρ ΡΠΈΡΡΠ΅ΠΌΡ Π½Π°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΡ Π±Π΅Π·ΠΏΠ΅ΠΊΠΈ .
ΠΠ»ΡΡΠΎΠ²Ρ ΡΠ»ΠΎΠ²Π°: Π½Π°ΡΡΠΎΠ½Π°Π»ΡΠ½Π° Π±Π΅Π·ΠΏΠ΅ΠΊΠ°, ΡΡΠΈΠ΄ΠΈΡΠ½ΠΈΠΉ ΡΠΈΠ·ΠΈΠΊ.Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΎΠ±ΡΠ°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠΈΡΡΠ΅ΠΌΡ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ ΠΌΠ΅ΡΡΠΎ ΠΈ ΡΠΎΠ»Ρ ΡΡΠΈΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ° ΠΏΡΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΈΡΡΠ΅ΠΌΡ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ
Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ. ΠΠ½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅ΡΡΡ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΡ Β«ΡΡΠΈΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΡΠΊΒ» ΠΈ Π΅Π³ΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅, ΡΡΠ»ΠΎΠ²ΠΈΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠ΅Π΄Π»Π°Π³Π°ΡΡΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΈΡΠΊΠ°ΠΌ ΠΈ ΠΏΠΎΠ΄Π°Π΅ΡΡΡ ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΈΠ΄ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΡΠΊΠΎΠ² Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ
ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ, ΡΡΠΈΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΡΠΊ.The problems of forming and development of the system of national safety are examined
in the article. The general model of the system of national safety is offered and the role of legal
risk is determined in this system. The location and role of legal risk is determined at functioning of the system of national safety. A category is analysed Β«legal riskΒ» and his basic component elements, terms of origin and functioning. The terms of counteraction risks are offered
and the model of decline of legal risks is given in the system of national safety.
Key words: national safety, legal risk
Antidepressantuse and the risk of hip fracture: A self-controlled case series approach in two primary care databases
Background: The use of antidepressants(AD,selective serotonin reuptake inhibitors,SSRI, or tricyclic antidepressants,TCA) has been associated with hip fractures(HF) in observational studies.However, it has been suggested that such results may be confounded by unmeasured patient characteristics. Objectives: To assess the effect of AD use on the risk of HF using self-controlled case series design. Methods: A self-controlled case series study was conducted in two primary care databases among patients with a first HF and a prescription for AD at any time during observation.Data were extracted from the UK THIN and the Dutch Mondriaan GP databases of the period 2001-2009.The incidence rate ratio(IRR) of HF for periods of AD use versus no AD use was estimated using conditional Poisson regression. Results: There were 6,632 and 136 HF patients for analysis in THIN and Mondriaan, respectively.After adjustment for age, an increased risk of HF was observed during the 30 day period after AD initiation: IRR 1.57 (95% CI, 1.39-1.78) in THIN and 3.22 (1.51-6.84) in Mondriaan.The increased risk was also observed during the next six months of AD use: IRR 1.52(1.39-1.65) in THIN and 2.76 (1.69-4.50) in Mondriaan.In the period after six months, the risk remained higher in THIN (IRR: 1.47; 1.31-1.65) but not significant in Mondriaan (IRR 1.94; 0.84-4.47). Furthermore, an increased risk of HF was observed during the 30 day period prior to AD initiation (IRR 1.22; 1.06-1.41) in THIN and (IRR 2.51; 1.00-6.33) in Mondriaan.In both THIN and Mondriaan, when cases were censored at the event times (HF) there appeared to be a substantial bias in IRR in all the periods: IRR during the 30 day period after AD initiation: 3.07 (2.66-3.54) in THIN and 12.34 (2.13-71.54) in Mondriaan.The risk of HF was higher in SSRI users than TCA users (4.39; 2.42-7.99 vs. 1.39; 0.58-2.41) in Mondriaan but was similar in THIN (1.49; 1.36- 1.63 vs. 1.49; 1.33-1.66). Conclusions: The incidence rate of hip fractures was higher in the periods both immediately after the start of AD use and during the first six months of AD use compared to periods of no use, although the magnitude of the risk varied between databases
Antidepressant Use and the Risk of Hip Fracture : A Self-Controlled Case Series Approach in Two Primary Care Databases
Background: The use of antidepressants(AD,selective serotonin reuptake inhibitors,SSRI, or tricyclic antidepressants,TCA) has been associated with hip fractures(HF) in observational studies.However, it has been suggested that such results may be confounded by unmeasured patient characteristics. Objectives: To assess the effect of AD use on the risk of HF using self-controlled case series design. Methods: A self-controlled case series study was conducted in two primary care databases among patients with a first HF and a prescription for AD at any time during observation.Data were extracted from the UK THIN and the Dutch Mondriaan GP databases of the period 2001-2009.The incidence rate ratio(IRR) of HF for periods of AD use versus no AD use was estimated using conditional Poisson regression. Results: There were 6,632 and 136 HF patients for analysis in THIN and Mondriaan, respectively.After adjustment for age, an increased risk of HF was observed during the 30 day period after AD initiation: IRR 1.57 (95% CI, 1.39-1.78) in THIN and 3.22 (1.51-6.84) in Mondriaan.The increased risk was also observed during the next six months of AD use: IRR 1.52(1.39-1.65) in THIN and 2.76 (1.69-4.50) in Mondriaan.In the period after six months, the risk remained higher in THIN (IRR: 1.47; 1.31-1.65) but not significant in Mondriaan (IRR 1.94; 0.84-4.47). Furthermore, an increased risk of HF was observed during the 30 day period prior to AD initiation (IRR 1.22; 1.06-1.41) in THIN and (IRR 2.51; 1.00-6.33) in Mondriaan.In both THIN and Mondriaan, when cases were censored at the event times (HF) there appeared to be a substantial bias in IRR in all the periods: IRR during the 30 day period after AD initiation: 3.07 (2.66-3.54) in THIN and 12.34 (2.13-71.54) in Mondriaan.The risk of HF was higher in SSRI users than TCA users (4.39; 2.42-7.99 vs. 1.39; 0.58-2.41) in Mondriaan but was similar in THIN (1.49; 1.36- 1.63 vs. 1.49; 1.33-1.66). Conclusions: The incidence rate of hip fractures was higher in the periods both immediately after the start of AD use and during the first six months of AD use compared to periods of no use, although the magnitude of the risk varied between databases
Antidepressant Use and the Risk of Hip Fracture: A Self-Controlled Case Series Approach in Two Primary Care Databases
Background: The use of antidepressants(AD,selective serotonin reuptake inhibitors,SSRI, or tricyclic antidepressants,TCA) has been associated with hip fractures(HF) in observational studies.However, it has been suggested that such results may be confounded by unmeasured patient characteristics. Objectives: To assess the effect of AD use on the risk of HF using self-controlled case series design. Methods: A self-controlled case series study was conducted in two primary care databases among patients with a first HF and a prescription for AD at any time during observation.Data were extracted from the UK THIN and the Dutch Mondriaan GP databases of the period 2001-2009.The incidence rate ratio(IRR) of HF for periods of AD use versus no AD use was estimated using conditional Poisson regression. Results: There were 6,632 and 136 HF patients for analysis in THIN and Mondriaan, respectively.After adjustment for age, an increased risk of HF was observed during the 30 day period after AD initiation: IRR 1.57 (95% CI, 1.39-1.78) in THIN and 3.22 (1.51-6.84) in Mondriaan.The increased risk was also observed during the next six months of AD use: IRR 1.52(1.39-1.65) in THIN and 2.76 (1.69-4.50) in Mondriaan.In the period after six months, the risk remained higher in THIN (IRR: 1.47; 1.31-1.65) but not significant in Mondriaan (IRR 1.94; 0.84-4.47). Furthermore, an increased risk of HF was observed during the 30 day period prior to AD initiation (IRR 1.22; 1.06-1.41) in THIN and (IRR 2.51; 1.00-6.33) in Mondriaan.In both THIN and Mondriaan, when cases were censored at the event times (HF) there appeared to be a substantial bias in IRR in all the periods: IRR during the 30 day period after AD initiation: 3.07 (2.66-3.54) in THIN and 12.34 (2.13-71.54) in Mondriaan.The risk of HF was higher in SSRI users than TCA users (4.39; 2.42-7.99 vs. 1.39; 0.58-2.41) in Mondriaan but was similar in THIN (1.49; 1.36- 1.63 vs. 1.49; 1.33-1.66). Conclusions: The incidence rate of hip fractures was higher in the periods both immediately after the start of AD use and during the first six months of AD use compared to periods of no use, although the magnitude of the risk varied between databases