Effects of Indomethacin on Prostaglandin E2 in 7,12-Dimethybenz (A) Anthracene induced Mammary Tumorigenisis in Rats fed Different Levels of Polyunsaturated Fat

A thesis presented to the faculty of the School of Arts and Sciences at Morehead State University in partial fulfillment of the requirement for the Degree of Masters of Science in Biology by Candace Sue Smith on August 5, 1988

Telavancin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA)

Telavancin is a bactericidal lipoglycopeptide antibiotic that is structurally related to vancomycin. It demonstrates in vitro activity against a variety of Gram-positive pathogens including, but not limited to, methicillin-resistant Staphylococcus aureus (MRSA). Telavancin is currently FDA-approved for the treatment of complicated skin and skin-structure infections. Recently, two randomized clinical trials demonstrated the efficacy and safety of telavancin compared to vancomycin for the treatment of nosocomial pneumonia. Overall, telavancin has a favorable safety profile. However, mild gastrointestinal disturbances and reversible increases in serum creatinine were observed in clinical studies. Additional clinical studies are needed to evaluate telavancin’s efficacy and safety in comparison to other antistaphylococcal agents for the treatment of infections such as bacteremia and endocarditis

Personal Experiences with Violence, Fear of Crime, and Mental Health Outcomes for Adolescents in Chicago

Over the last several decades, an increasing amount of research has focused on fear of crime. Studies have found that fear of crime is often influenced by actual and perceived risks of victimization. Significant consequences of fear of crime have been found to include behavioral changes, adverse health outcomes, and neighborhood decline. However, fear of crime studies have predominately used cross-sectional data with adult samples. By using longitudinal data and focusing on adolescents, this study attempts to address these gaps in the literature. Data from the Project on Human Development in Chicago Neighborhoods are examined to answer the study’s research questions. More explicitly, structural equation modeling is used to evaluate the impact of personal experiences with violence, including violent victimization, witnessing the violent victimization of others, and involvement in violence, on fear of crime among adolescents living in Chicago. Informed by stress theory, the impact of personal experiences with crime and fear of crime on mental health, explicitly internalizing and externalizing problems, is addressed as well. Results suggest that violent victimization increases fear of crime, witnessing violence is unrelated to fear, and crime involvement decreases fear. In addition, the study finds that being violently victimized is positively associated with both internalization and externalization, witnessing violence is associated with lower levels of internalization and not associated with externalization, and involvement in violence is associated with neither internalization nor externalization. Fear of crime is not found to mediate any of the relationships between personal experiences with violence and mental health. Limitations of the study are presented, and ideas for future research are addressed

Impacts of Climate Change on Narragansett Bay

The objective of this paper is to examine the impacts of global climate change on Rhode Island\u27s coastal ecosystems. Average annual air temperature in Rhode Island has increased by 1.7 °C since 1880, water temperatures of Narragansett Bay have increased by 1.2 °C since 1950, precipitation increased 27% between 1895 and 1999, and sea level rose 0.13 m between 1931 and 2007. We can already see the effects of these climatic changes on the Narragansett Bay ecosystem, including ecological changes in the Bay\u27s food web from phytoplankton and Zooplankton to fish, e.g., changes in phenology of seasonal phytoplankton blooms and dominant fish species (e.g., Pseudopleuronectes americanus [Winter Flounder]). These climatic changes have increased freshwater inputs and the concomitant pollutant loads into the Bay. Rising sea level has contributed to ongoing erosion of the coast and has put waterfront homes at increased risk. It is imperative to continue monitoring these effects

The Effects of Part-Time Work on Sleep Quality in College Students

Part time work can negatively affect sleeping patterns, resulting in poorer academic performance and a diminished sense of overall well-being. 521 undergraduate students working at least 20 hours per week were surveyed and self-reported post-work experiences and sleep quality. Results of a multiple regression analysis indicated that a block of four post-work experiences (psychological detachment, relaxation, mastery, and control over leisure time) were predictive of self-reported sleep quality. Completion of more mastery experiences and greater control over choosing post-work activities were both statistically significant predictors of higher sleep quality (Sonnentag, Binnewies, & Mojza, 2008).https://scholarscompass.vcu.edu/uresposters/1139/thumbnail.jp

Applications of Variable Number Tandem Repeat Genotyping in the Validation of an Animal Medical Model and Gene Flow Studies in Threatened Populations of Reptiles

We used variable number tandem repeats (VNTR) to validate the chicken as a human medical model for Pulmonary Arterial Hypertension. We identified seven regions on four chromosomes and interrogated for VNTR markers that significantly associate with Pulmonary Hypertension Syndrome/ascites. In those regions, we identified 7 candidate genes; AGTR1, ACE, p38MAPK, SST, 5HT2B, NET1, and CALM3 for further analysis as significantly contributing QTL for ascites/PHS. We also used variable number tandem repeats to measure gene flow and gather evidence for multiple paternity in a population of Timber rattlesnakes, Crotalus horridus. We were able to verify 1 VNTR that can be used to assess gene flow in and among our populations. We were also able to use this VNTR to provide evidence of multiple paternity in the Timber rattlesnake

China syndrome : how the rise of Chinese competition affects SME performance in Canada and the U.S.?

1 online resource (52 p.) : col. ill.Includes abstract and appendices.Includes bibliographical references (p. 29-32).This thesis delves into the competitiveness of North American Small and Medium Enterprises (SMEs) in an increasingly global marketplace. It examines how they fare against increased competition from low-wage countries such as China in their local markets. Increased competition is good for the consumer in that it usually leads to greater options in the marketplace as well more efficient processes reflected by reduced market prices (Hatzichronoglou, 1996). However, markets with intense rivalry or which are perfectly competitive turn into a zero sum game in which profits are not sustainable and businesses cannot sustain business. SMEs were found to be more so negatively impacted by Chinese import competition than large firms, and 3-5% more likely to incur bankruptcy due to this import competition

Decadal Patterns of Westerly Winds, Temperatures, Ocean Gyre Circulations and Fish Abundance: A Review

The purpose of this review is to describe the global scope of the multidecadal climate oscillations that go back at least, through several hundred years. Literature, historic data, satellite data and global circulation model output have been used to provide evidence for the zonal and meridional jet stream patterns. These patterns were predominantly zonal from the 1970s to 1990s and switched since the 1990s to a meridional wind phase, with weakening jet streams forming Rossby waves in the northern and southern hemispheres. A weakened northern jet stream has allowed northerly winds to flow down over the continents in the northern hemisphere during the winter period, causing some harsh winters and slowing anthropogenic climate warming regionally. Wind oscillations impact ocean gyre circulation affecting upwelling strength and pelagic fish abundance with synchronous behavior in sub Arctic gyres during phases of the oscillation and asynchronous behavior in subtropical gyres between the Atlantic and Pacific oceans

Demographic and Socioeconomic Factors Associated With HPV Vaccination in Georgia’s South Central Health District

Background: Human Papillomavirus (HPV) subtypes are the primary cause of cervical cancer. Despite introduction of the HPV vaccine in 2006, vaccination percentages remain low across Georgia counties. The primary objective of this research was to conduct a descriptive epidemiological study of HPV vaccination coverage among individuals in the South Central Health District (SCHD) to provide guidance for targeted vaccination campaigns aimed at adolescents residing in rural communities. Methods: Data from the Georgia Registry of Immunization Transactions and Services and AEGIS.net, Inc. were used to analyze demographic and socioeconomic factors associated with HPV vaccine uptake among individuals visiting county health departments in the SCHD from 2007-2014. Descriptive statistics were used to evaluate the relationship between sex, age at first vaccination, county of vaccine administration, race, and insurance status to vaccine series completion. Results: In the SCHD, Johnson County had the highest completion percentage (50%); Montgomery County had the lowest (20%). However, Montgomery County had the fastest time to completion (334 days). Throughout the district, males were fully vaccinated at much lower percentages than females (p \u3c 0.001). Race was a significant variable (p=0.011) for vaccine completion. Compared to other racial groups, more White individuals completed the HPV vaccine. Absolute counts of HPV vaccine doses peaked in the study population during 2010 (n=507). Conclusions: Due to overall low rates, community-based intervention methods should be considered to increase HPV vaccine uptake across the SCHD. School-based programs may be useful in targeting at-risk populations and increasing rates of HPV vaccine initiation and completion. Expanded efforts are needed to determine the best structure for effective school-based programs

The Ursinus Weekly, October 18, 1965

All freshmen offered free concert trip • Frats offer pre-rushing advice to frosh • Curtain Club selects cast for Rice\u27s The Adding machine • Editorial: The Parents\u27 Day predicament • Dean\u27s List published: 114 students honored • Spanish Club organizes • Fletcher gives ACS address • International career and study conferences set • Freshman class elects officers • Waldo joins history staff • Town book store opens today • Groups discuss A plus topic pick • Hilderbrand speaks to 230 at neighborhood good will dinner • Chapel schedule • Editorial: Dining hall difficulties • Religion may die warns Dr. Miller; Forum speaker stirs audience • Library inventory bewilders many honest students • 100% organization revitalizing UC • Glossacelia phenomenon makes smashing debut at Kaffee Klatch • Rosemont varsity bows to UC\u27s JV • JV squad victors over Chestnut Hill • Wilkes swamps UC • Intramural corner • Soccer team loses • Weekly feature editor nominates character for Snob\u27s hall of fame • Music groups select new officers • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1206/thumbnail.jp