Political preferences of generation Y university student with regards to governance and social media: A study on march 2014 local elections

Governance denotes transparency, clarity, accountability, participation, effectiveness, respect to law and social responsibility. These aspects necessitate that everybody should be aware of their right and responsibilities and also claim them. Thus, a new citizenship consciousness has been developing. This consciousness symbolizes a new individual identity claiming their rights for problems and demanding high standards. In this context, the means of social media are getting used more and more by young publics to realize governance, especially Generation Y

Effect of low-energy shockwave therapy on angiogenic factors in the penile tissue of diabetic rats

Objective: The aim of this study is to investigate the effect of low-energy shock wave therapy (LESWT) on angiogenesis factors at penile tissue in a diabetic rat model

Association of Polymorphisms in MCP-1, CCR2, and CCR5 Genes with the Risk and Clinicopathological Characteristics of Prostate Cancer

The aim of our study was to determine the effect of monocyte chemotactic protein-1 (MCP-1), CC chemokine receptor 2 (CCR2), and CC chemokine receptor 5 (CCR5) gene polymorphisms on the susceptibility and clinicopathological characteristics of prostate cancer. Genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method in 156 histopathologically confirmed prostate cancer patients and 152 healthy subjects. Individuals with AA genotype or at least one A allele of CCR2 V64I gene polymorphism had a higher risk for prostate cancer as compared with those with GG genotype (p = 0.010 and p = 0.028, respectively). CCR5 Delta 32/wt genotype and CCR5 Delta 32 allele were also found to be involved in the susceptibility to prostate cancer (p = 0.028 and p = 0.030, respectively). However, there was no significant association between MCP-1-2518 A/G gene polymorphism and prostate cancer risk. Prostate cancer patients carrying AA genotype or at least one A allele of CCR2 V64I had significantly increased risk for high stage disease (p = 0.002 and p = 0.039, respectively) and metastasis (p = 0.004 and p = 0.022, respectively). The CCR2 A allele (64I allele) was significantly associated with high T stage (p = 0.001) and metastasis (p = 0.005) as compared with CCR2 G allele (64V allele). Our data indicate that gene polymorphism of CCR2 V64I may influence the susceptibility and clinicopathological characteristics of prostate cancer and CCR5 Delta 32 allele may also be an important risk factor for prostate cancer in Turkish men population

Genetic variants of MnSOD and GPX1 and susceptibility to bladder cancer in a Turkish population

This study was conducted to investigate the association of genetic polymorphisms in the MnSOD and GPX1 genes with the risk and invasiveness of bladder cancer in a Turkish population. This prospectively designed study enrolled 157 patients with bladder cancer (mean age 63.2 +/- 10.86 years) and 224 healthy controls (mean age 61.7 +/- 8.39 years). Genotyping of the MnSOD Ala-9Val and GPX1 Pro198Leu polymorphisms was carried out by PCR-RFLP. No significant difference was found in MnSOD genotype distributions between the controls and the bladder cancer patients. However, the Leu/Leu genotype of GPX1 was associated with a significantly higher risk of bladder cancer than the Pro/Pro genotype. When stratified according to tumor stage, the Leu/Leu genotype of GPX1 was more frequently observed in bladder cancer patients with high-stage tumors than those with low-stage tumors. Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer. In conclusion, the present study indicates that the GPX1 Pro198Leu polymorphism may be associated with the risk and development of invasive bladder cancer. In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk

Despite the lack of association between different genotypes and the presence of prostate cancer, endothelial nitric oxide Synthase a/b (eNOS4a/b) polymorphism may be associated with advanced clinical stage and bone metastasis

Objectives: To investigate the relationship between the distribution of endothelial NO synthase (eNOS4a/b) gene polymorphism and clinical features of prostate cancer (PCa)

The Relationship Between Cyclo-Oxygenase-2 -1195A/G Gene Polymorphism and Renal Cell Carcinoma

Objective: This study was aimed to evaluate the association of cyclo-oxygenase 2 (COX-2) -1195A/G polymorphism with initiation and progression of renal cell carcinoma (RCC) and interaction with smoking in RCC patients in a Turkish population

Increased risk of advanced prostate cancer associated with MnSOD Ala-9-Val gene polymorphism

We aimed to investigate the association between manganese superoxide dismutase (MnSOD) Ala-9-Val gene polymorphism and the initiation and/or progression of prostate cancer (PCa) as well as to evaluate its potential interactions with advanced age and smoking status. MnSOD Ala-9-Val gene polymorphism was carried out in 134 (mean age 64.1 +/- A 7.48) PCa patients and 159 (mean age 62.5 +/- A 7.53) healthy controls with serum prostate specific antigen (PSA) levels (< 4 ng/ml) and normal digital rectal examination (DRE) findings in this prospectively designed study. PCa patients were classified as low stage disease (T(1) or T(2) and N(0)M(0) stages) and high stage disease (T(3) or T(4) and N(0)M(0) or N(1) or M(1) stages). Genotypes for MnSOD Ala-9-Val gene polymorphism were identified by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFPL). Despite lack of association between different genotypes of MnSOD Ala-9-Val gene polymorphism and the presence of PCa, patients with Ala/Ala genotype were at an increased risk of high stage disease compared with those with the Val/Val genotype [odds ratio (OR), 3.77; 95% CI, 1.30-10.94; P = 0.012]. However, no significant difference was observed in the distribution of each genotype among PCa patients, with respect to tumor grade. On the other hand, smoking status and aging did not seem to change the association between genotypes and PCa risk. Ala/Ala genotype of MnSOD polymorphism may have an effect on adverse features of PCa such as high stage disease