2016 Baccalaureate Mass Homily

Homily delivered at the 2016 Baccalaureate Mass as part of the 170th Commencement of the College of the Holy Cross. The homilist, Rev. William R. Campbell, S.J., is the Vice President for Mission at the College of the Holy Cross. He is also an alumnus of the College, Class of 1987.https://crossworks.holycross.edu/bacc_homily/1001/thumbnail.jp

Urban futures: the sustainable management of the ground beneath cities

Over half of the world's population now live in cities. In 2011 it was estimated that the global population exceeded 7 billion. Pressures on the environment including land use are increasing. The ground beneath cities and the interaction between physical, biological and chemical processes provides natural capital on which society depends. These benefits and the ground properties and processes that support and deliver them can be considered ecosystem services. Characterizing the ground properties on which ecosystem services depend involves a qualitative assessment of positive and negative impacts of proposed urban sustainability solutions, including use of the ground. The sustainability of a proposed solution depends on how the future might unfold. Future scenario analysis allows consideration of the social, technological, economic, environmental and political changes that may determine the ability of a proposed solution to deliver its benefits now and in the future. Analysis of the positive and negative impacts of a proposed use of the ground on ecosystem function, measured against future scenarios of change, can be integrated to deliver strategies for the future management of the ground and the wider environment beneath cities

Property A and affine buildings

AbstractYu's Property A is a non-equivariant generalisation of amenability introduced in his study of the coarse Baum Connes conjecture. In this paper we show that all affine buildings of type A˜2, B˜2 and G˜2 have Property A. Together with results of Guentner, Higson and Weinberger, this completes a programme to show that all affine building have Property A. In passing we use our technique to obtain a new proof for groups acting on A˜n buildings

Understanding FEV1 for the purpose of cystic fibrosis registry comparisons: Does bias in annual review FEV1 affect between-centre comparison within the UK? An analysis of registry data

Rationale, aims and objective: We previously demonstrated that annual review %FEV1 under-estimates lung health of adults with CF compared to %FEV1 captured during periods of clinical stability. This has implications in the comparisons against registries with encounter-based FEV1, such as the US. It is uncertain whether this bias affects between-centre comparison within the UK. Previous funnel plot analyses have identified variation in annual review %FEV1 according to centre size, hence we investigated whether paired differences between annual review and best %FEV1 also vary according to centre size. Methods: This registry analysis included 18 adult CF centres in the UK with ≥80% completeness for best FEV1 data in 2014. Mean discrepancy between annual review and best %FEV1 is a surrogate for the extent by which annual review %FEV1 underestimates lung health; and was plotted against centre size. A Local Polynomial Regression (LOESS) curve was used to explore the relationship between the two variables. An appropriate model is fitted based on the LOESS curve to determine the strength of relationship between discrepancies in %FEV1 and centre size. Results: There is an inverted U-shaped relationship between mean discrepancies in %FEV1 and centre size. A regression of the paired mean difference in %FEV1 against centre size showed a significant improvement in the goodness of fit for a quadratic model (R2 = 23.8% for a quadratic model compared with 0.4% for a linear one; p = 0.048 for the quadratic term). Conclusions: Annual review %FEV1 under-estimated lung health of adults from small and large centres in the UK to a greater extent compared to medium-sized centres. A plot of %FEV1 against centre size (e.g. funnel plot comparison) would be affected by systematic bias in annual review %FEV1. Therefore, annual review %FEV1 is an unreliable metric to compare health outcomes of adult CF centres within the UK

The Legacy of ERA, Privatization and the Policy Ratchet

This article explores the ways in which the neo-liberal impetus toward the privatization of state schooling signalled in the Education Reform Act 1988 (ERA) has become embedded in the English school system. Four main points are made. First, that ERA itself was of huge strategic rather than substantive importance as far as privatization is concerned. Second, by tracing the lineage of privatization from ERA onwards a 'ratchet' effect of small and incremental policy moves can be identified, which have disseminated, embedded and naturalized privatization within public sector provision. Third, that while privatization has been taken up and taken much further by New Labour than it had been by the Conservatives there are differences between the two sets of governments in the role of privatization in education policy and the role of the state. Fourth, the participation of private providers in the planning and delivery of state services has put the private sector at the very heart of policy. At points the article draws upon interviews conducted with private sector providers. © 2008 Sage Publications

The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma

The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel–/– mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss also led to earlier onset of disease in a separate TCL1-Tg-driven lymphoma model. Tumour reimplantation experiments indicated that this is an effect intrinsic to the Eμ-Myc lymphoma cells but, counterintuitively, c-rel–/– Eμ-Myc lymphoma cells were more sensitive to apoptotic stimuli. To learn more about why loss of c-Rel led to earlier onset of disease, microarray gene expression analysis was performed on B cells from 4-week-old, wild-type and c-rel–/– Eμ-Myc mice. Extensive changes in gene expression were not seen at this age, but among those transcripts significantly downregulated by the loss of c-Rel was the B-cell tumour suppressor BTB and CNC homology 2 (Bach2). Quantitative PCR and western blot analysis confirmed loss of Bach2 in c-Rel mutant Eμ-Myc tumours at both 4 weeks and the terminal stages of disease. Moreover, Bach2 expression was also downregulated in c-rel–/– TCL1-Tg mice and RelA Thr505Ala mutant Eμ-Myc mice. Analysis of wild-type Eμ-Myc mice demonstrated that the population expressing low levels of Bach2 exhibited the earlier onset of lymphoma seen in c-rel–/– mice. Confirming the relevance of these findings to human disease, analysis of chromatin immunoprecipitation sequencing data revealed that Bach2 is a c-Rel and NF-κB target gene in transformed human B cells, whereas treatment of Burkitt's lymphoma cells with inhibitors of the NF-κB/IκB kinase pathway or deletion of c-Rel or RelA resulted in loss of Bach2 expression. These data reveal a surprising tumour suppressor role for c-Rel in lymphoma development explained by regulation of Bach2 expression, underlining the context-dependent complexity of NF-κB signalling in cancer

Rescue therapy within the UK Cystic Fibrosis registry: an exploration of the predictors of intravenous antibiotic use amongst adults with CF

Background and objective: Intravenous (i.v.) antibiotics are needed for rescue when preventative therapy fails to achieve stability among adults with cystic fibrosis (CF). Understanding the distribution of i.v. days can provide insight into the care that adults with CF need. We aim to determine the baseline characteristics that are associated with higher i.v. use, in particular to test the hypothesis that prior-year i.v. use is associated with future-year i.v. use. Methods: This is a cross-sectional analysis of the 2013–2014 UK CF registry data. Stepwise logistic regression was performed using current-year i.v. days as the dependent variable, and demographic variables including prior-year i.v. days as the covariates. Based on these results, study sample was divided into clinically meaningful subgroups using analysis similar to tree-based method. Results: Data were available for 4269 adults in 2013 and 4644 adults in 2014. Prior-year i.v. use was the strongest predictor for current-year i.v. use followed by forced expiratory volume in 1 s (FEV1). Adults with high prioryear i.v. use (>14 days) continued to require high levels of i.v., regardless of FEV1. Those with high prior-year i. v. use and FEV1 ≥70% had higher current-year i.v. days compared to adults with low prior-year i.v. use and FEV1 <40% (28 days, interquartile range (IQR): 11–41 days vs 14 days, IQR: 0–28 days; Mann–Whitney P-value <0.001 in 2013). Conclusion: CF people with prior high levels of rescue often continue to need high levels of rescue even if they have good FEV1. The reasons for this require further investigations

The Stellar-Disk Electric (Short) Circuit: Observational Predictions for a YSO Jet Flow

We discuss the star-disk electric circuit for a young stellar object (YSO) and calculate the expected torques on the star and the disk. We obtain the same disk magnetic field and star-disk torques as given by standard magnetohydrodynamic (MHD) analysis. We show how a short circuit in the star-disk electric circuit may produce a magnetically-driven jet flow from the inner edge of a disk surrounding a young star. An unsteady bipolar jet flow is produced that flows perpendicular to the disk plane. Jet speeds of order hundreds of kilometres per second are possible, while the outflow mass loss rate is proportional to the mass accretion rate and is a function of the disk inner radius relative to the disk co-rotation radius.Comment: 6 pages, 8 figures, Accepted for publication in Astrophysics & Space Scienc

Exploring the implications of different approaches to estimate centre-level adherence using objective adherence data in an adult cystic fibrosis centre - a retrospective observational study

Background Accurate centre-level medication adherence measurement allows identification of highly performing CF centres, drives shared learning and informs quality improvement. Self-reported adherence is unreliable but data-logging nebulisers can capture objective data. However, adherence levels in current literature are limited by the use of agreed prescriptions and convenience sampling. In this single-centre retrospective study, we quantified the differences in centre-level adherence with different methods of calculating adherence (unadjusted vs normative adherence) and different data sampling frames (convenience sampling vs including difficult to obtain data). Methods Adherence data were objectively captured using I-neb® from 2013-2016 in Sheffield Adult CF Centre. Adults on non data-logging devices, on ivacaftor or with previous lung transplantation were excluded. Adherence was calculated based on agreed regimen (‘unadjusted adherence’) or minimum required regimen (‘normative adherence’). I-nebs® not brought to clinic were downloaded during home visits. Adults not on any inhaled therapy but with chronic Pseudomonas aeruginosa infection were included by counting their adherence as “0”. Results Of the 131 included adults, 126 provided I-neb® data. Calculating unadjusted adherence from I-nebs® brought to clinics resulted in the highest centre-level adherence (median 41.8% in 2013). Median adherence reduced after sequentially accounting for minimum required regimen (40.0% in 2013), I-nebs® not brought to clinics (32.9% in 2013) and adults not on any inhaled therapy (31.0% in 2013). Conclusions Different approaches of calculating adherence produced different adherence levels. Adherence levels based only on agreed regimen among adults who readily brought their nebulisers to clinics can over-estimate the effective adherence of CF centres