a variational approach to niche construction

In evolutionary biology, niche construction is sometimes described as a genuine evolutionary process whereby organisms, through their activities and regulatory mechanisms, modify their environment such as to steer their own evolutionary trajectory, and that of other species. There is ongoing debate, however, on the extent to which niche construction ought to be considered a bona fide evolutionary force, on a par with natural selection. Recent formulations of the variational free-energy principle as applied to the life sciences describe the properties of living systems, and their selection in evolution, in terms of variational inference. We argue that niche construction can be described using a variational approach. We propose new arguments to support the niche construction perspective, and to extend the variational approach to niche construction to current perspectives in various scientific fields

Flow Dynamics of an Accumulation Basin: A Case Study of Upper Kahiltna Glacier, Mount McKinley, Alaska

We interpreted flow dynamics of the Kahiltna Pass Basin accumulation zone on Mount McKinley, Alaska, USA, using 40, 100 and 900 MHz ground-penetrating radar profiles and GPS surface velocity measurements. We found dipping, englacial surface-conformable strata that experienced vertical thickening as the glacier flowed westward from a steep, higher-velocity (60 m a−1) region into flat terrain associated with a 90° bend in the glacier and lower velocities (15 m a−1) to the south. Stratigraphy near the western side of the basin was surface-conformable to ∼170 m depth and thinned as flow diverged southward, down-glacier. We found complex strata beneath the conformable stratigraphy and interpret these features as buried crevasses, avalanche debris and deformed ice caused by up-glacier events. We also suggest that basin dimensions, bed topography and the sharp bend each cause flow extension and compression, significantly contributing to conformable and complex strata thickness variations. Our findings show that surface-conformable stratigraphy continuous with depth and consistent strata thicknesses cannot be assumed in accumulation basins, because local and up-glacier terrain and flow dynamics can cause structural complexities to occur under and within surface-conformable layers

Melt Regimes, Stratigraphy, Flow Dynamics and Glaciochemistry of Three Glaciers in the Alaska Range

We used ground-penetrating radar (GPR), GPS and glaciochemistry to evaluate melt regimes and ice depths, important variables for mass-balance and ice-volume studies, of Upper Yentna Glacier, Upper Kahiltna Glacier and the Mount Hunter ice divide, Alaska. We show the wet, percolation and dry snow zones located below 2700ma.s.l., at 2700 to 3900ma.s.l. and above 3900ma.s.l., respectively. We successfully imaged glacier ice depths upwards of 480m using 40–100MHz GPR frequencies. This depth is nearly double previous depth measurements reached using mid-frequency GPR systems on temperate glaciers. Few Holocene-length climate records are available in Alaska, hence we also assess stratigraphy and flow dynamics at each study site as a potential ice-core location. Ice layers in shallow firn cores and attenuated glaciochemical signals or lacking strata in GPR profiles collected on Upper Yentna Glacier suggest that regions below 2800ma.s.l. are inappropriate for paleoclimate studies because of chemical diffusion, through melt. Flow complexities on Kahiltna Glacier preclude ice-core climate studies. Minimal signs of melt or deformation, and depth–age model estimates suggesting 4815 years of ice on the Mount Hunter ice divide (3912ma.s.l.) make it a suitable Holocene-age ice-core location

An open reproducible framework for the study of the iterated prisoner's dilemma

The Axelrod library is an open source Python package that allows for reproducible game theoretic research into the Iterated Prisoner's Dilemma. This area of research began in the 1980s but suffers from a lack of documentation and test code. The goal of the library is to provide such a resource, with facilities for the design of new strategies and interactions between them, as well as conducting tournaments and ecological simulations for populations of strategies. With a growing collection of 139 strategies, the library is a also a platform for an original tournament that, in itself, is of interest to the game theoretic community. This paper describes the Iterated Prisoner's Dilemma, the Axelrod library and its development, and insights gained from some novel research.Comment: 11 pages, Journal of Open Research Software 4.1 (2016

Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells

Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for relapse, and additional approaches to deplete CML LSC are needed to enhance the possibility of discontinuing TKI treatment. We have previously reported that expression of the pivotal proinflammatory cytokine interleukin-1 (IL-1) is increased in CML bone marrow (BM). We show here that CML LSC demonstrated increased expression of the IL-1 receptors, IL-1RAP and IL- 1R1, and enhanced sensitivity to IL-1-induced NF-KB signaling compared to normal stem cells. Treatment with recombinant IL-1 receptor antagonist (IL-1RA) inhibited IL-1 signaling in CML LSC and inhibited growth of CML LSC. Importantly, the combination of IL-1RA with TKI resulted in significantly greater inhibition of CML LSC compared with TKI alone. Our studies also suggest that IL-1 signaling contributes to overexpression of inflammatory mediators in CML LSC, suggesting that blocking IL-1 signaling could modulate the inflammatory milieu. We conclude that IL-1 signaling contributes to maintenance of CML LSC following TKI treatment, and that IL- 1 blockade with IL-1RA enhances elimination of TKI-treated CML LSC. These results provide a strong rationale for further exploration of anti-IL-1 strategies to enhance LSC elimination in CML

Biologically significant residual persistence of brodifacoum in reptiles following invasive rodent eradication, Galapagos Islands, Ecuador

Rat eradication resulted in prolonged presence of the anticoagulant rodenticide brodifacoum in exposed lizards, likely significantly contributing to the deaths of secondarily exposed raptors up to at least 773 days after bait application

Archipelago-Wide Island Restoration in the Galápagos Islands: Reducing Costs of Invasive Mammal Eradication Programs and Reinvasion Risk

Invasive alien mammals are the major driver of biodiversity loss and ecosystem degradation on islands. Over the past three decades, invasive mammal eradication from islands has become one of society's most powerful tools for preventing extinction of insular endemics and restoring insular ecosystems. As practitioners tackle larger islands for restoration, three factors will heavily influence success and outcomes: the degree of local support, the ability to mitigate for non-target impacts, and the ability to eradicate non-native species more cost-effectively. Investments in removing invasive species, however, must be weighed against the risk of reintroduction. One way to reduce reintroduction risks is to eradicate the target invasive species from an entire archipelago, and thus eliminate readily available sources. We illustrate the costs and benefits of this approach with the efforts to remove invasive goats from the Galápagos Islands. Project Isabela, the world's largest island restoration effort to date, removed >140,000 goats from >500,000 ha for a cost of US$10.5 million. Leveraging the capacity built during Project Isabela, and given that goat reintroductions have been common over the past decade, we implemented an archipelago-wide goat eradication strategy. Feral goats remain on three islands in the archipelago, and removal efforts are underway. Efforts on the Galápagos Islands demonstrate that for some species, island size is no longer the limiting factor with respect to eradication. Rather, bureaucratic processes, financing, political will, and stakeholder approval appear to be the new challenges. Eradication efforts have delivered a suite of biodiversity benefits that are in the process of revealing themselves. The costs of rectifying intentional reintroductions are high in terms of financial and human resources. Reducing the archipelago-wide goat density to low levels is a technical approach to reducing reintroduction risk in the short-term, and is being complemented with a longer-term social approach focused on education and governance