Contamination Control Handbook for Ground Fluid Systems Final Technical Publication

Handbook for contamination control of aerospace ground fluid systems and portable equipmen

Alien Registration- Camp, William V. (Baldwin, Cumberland County)

https://digitalmaine.com/alien_docs/32829/thumbnail.jp

Critical insights into the pathogenesis of clinical isolates of pandemic influenza A(H1N1) 2009 virus in mouse and ferret models.

Influenza A virus (IAV) is a minus-sense, segmented, single-stranded RNA virus that infects the respiratory tract of humans and can cause severe illness. Novel IAV variants perpetually emerge on every continent, and the emergence of variants with increased transmissibility and/or pathogenesis in the human population is a serious concern for global public health. Infection with IAV typically causes an acute, self-limiting upper respiratory tract disease. However, severe IAV disease is characterized by infection of the lower respiratory tract which can lead to pneumonia and may result in the development of acute respiratory distress syndrome (ARDS). Viral and host contributions to the development of ARDS are poorly understood, however IAV pathogenesis has been linked mutations in the receptor binding protein and the viral polymerase. Ferrets and mice are two important laboratory animal models for studying IAV pathogenesis. In 2009, a novel H1N1 subtype IAV (H1N1pdm) emerged in the human population and displayed variable pathology in humans. Using a mouse model, we show the variability of clinical isolates of H1N1pdm is driven by viral mutations, and that the timing of the inflammatory response is correlated with disease severity. To investigate spatiotemporal aspects of potential host and viral contributions to influenza pathogenesis, we developed a live imaging platform for ferrets infected with a human clinical isolate of H1N1pdm. We detected an early recruitment of neutrophils into ferret lungs following infection, which accumulated at foci of H1N1pdm infection within specific anatomical regions of the lung by 24 hours post-infection. The neutrophil response was biphasic, characterized by the recruitment of two populations with differing gene expression profiles, and baseline neutrophil levels were increased throughout the entire lung, including areas with no apparent viral infection. Changes in the viral microenvironment resulted in the regeneration of lung epithelium during recovery phase of infection, and this was imaged with PET-CT using a radiolabeled glucose analog. In summary, these data illustrate critical features of the immune response to IAV, and emphasize important considerations about the timing and accuracy of innate immune responses in studying viral pathogenesis

Child Phonology: Dynamic Assessment of Speech Adaptability

Speech-language pathologists help children with speech sound disorders learn to say sounds like their peers. The purpose of this study is to determine how a child’s speech changes during treatment when given help. Traditionally, speech-language pathologists have only measured children’s speech sound production using assessments that provide no help. Our study is one of the first to evaluate a new assessment that measures the amount of help needed for children to be successful in producing speech sounds. We evaluated a single participant: a six-year, two-month old boy who had difficulties saying many sounds, which often were made as “t” or “d”. We assessed his progress on four sounds that he practiced over eight sessions. Sounds were selected because they were the most difficult sounds for him to say. The participant’s progress was recorded using the Glaspey Dynamic Assessment of Phonology (GDAP). We evaluated his average GDAP score for all sounds before and after treatment. We also evaluated his individual GDAP scores for each of the four hard sounds targeted during treatment. To gain additional information about his progress over time, we compared his GDAP scores to his pre- and post-treatment static probe scores, an assessment in which he received no help. Our study is significant as current treatment and assessment approaches for children with speech sound disorders do not address a child’s improved, aided performance. As such, traditional assessments are unable to provide information about a child’s specific needs. However, assessments that do provide help, take into account the child’s needs in order to attain correct production. Results from our research may provide implications for treatment target selection related to the amount of progress made toward hard sounds

Optomechanical Cavity Cooling of an Atomic Ensemble

We demonstrate cavity sideband cooling of a single collective motional mode of an atomic ensemble down to a mean phonon occupation number of 2.0(-0.3/+0.9). Both this minimum occupation number and the observed cooling rate are in good agreement with an optomechanical model. The cooling rate constant is proportional to the total photon scattering rate by the ensemble, demonstrating the cooperative character of the light-emission-induced cooling process. We deduce fundamental limits to cavity-cooling either the collective mode or, sympathetically, the single-atom degrees of freedom.Comment: Paper with supplemental material: 4+6 pages, 4 figures. Minor revisions of text. Supplemental material shortened by removal of supplementary figur

Study of Space Station propulsion system resupply and repair Final report

Resupply and repair capabilities for orbital space station bipropellant propulsion syste

The Realities of Contemporary Rental Agreements Require the Application of Implied Warranty of Habitability and Fitness as a Just and Necessary Implication from the Contractual Nature of a Lease of a Dwelling.

Abstract Forthcoming