Fate mapping identifies the origin of SHF/AHF progenitors in the chick primitive streak

Heart development depends on the spatio-temporally regulated contribution of progenitor cells from the primary, secondary and anterior heart fields. Primary heart field (PHF) cells are first recruited to form a linear heart tube; later, they contribute to the inflow myocardium of the four-chambered heart. Subsequently cells from the secondary (SHF) and anterior heart fields (AHF) are added to the heart tube and contribute to both the inflow and outflow myocardium. In amniotes, progenitors of the linear heart tube have been mapped to the anterior-middle region of the early primitive streak. After ingression, these cells are located within bilateral heart fields in the lateral plate mesoderm. On the other hand SHF/AHF field progenitors are situated anterior to the linear heart tube, however, the origin and location of these progenitors prior to the development of the heart tube remains elusive. Thus, an unresolved question in the process of cardiac development is where SHF/AHF progenitors originate from during gastrulation and whether they come from a region in the primitive streak distinct from that which generates the PHF. To determine the origin and location of SHF/AHF progenitors we used vital dye injection and tissue grafting experiments to map the location and ingression site of outflow myocardium progenitors in early primitive streak stage chicken embryos. Cells giving rise to the AHF ingressed from a rostral region of the primitive streak, termed region ‘A’. During development these cells were located in the cranial paraxial mesoderm and in the pharyngeal mesoderm. Furthermore we identified region ‘B’, located posterior to ‘A’, which gave rise to progenitors that contributed to the primary heart tube and the outflow tract. Our studies identify two regions in the early primitive streak, one which generates cells of the AHF and a second from which cardiac progenitors of the PHF and SHF emerge.Esther Camp, Susanne Dietrich, Andrea Münsterber

NASA/MSFC FY-83 Atmospheric Research Review

Atmospheric research conducted at the Marshall Space Flight Center in FY 1983 is discussed. Clear air turbulence, gusts, and fog dispersal near airports is discussed. The use of Doppler Lidar signals in discussed, as are low level flow conditions that are hazardous to aircraft

The maxometer-dynamic and static tests

The ability to withstand extreme environmental conditions, such as the high flow velocities and extreme temperatures associated with the launch of aerospace vehicles, was considered in the developement of two maxometer models which are capable of measuring extremely high wind speeds (130 m/sec) and retaining a record of the peak speed over any given time period. The dynamic and static tests of these models are reported, along with pertinent results

Maxometers (peak wind speed anemometers)

An instrument for measuring peak wind speeds under severe environmental conditions is described, comprising an elongated cylinder housed in an outer casing. The cylinder contains a piston attached to a longitudinally movable guided rod having a pressure disk mounted on one projecting end. Wind pressure against the pressure disk depresses the movable rod. When the wind reaches its maximum speed, the rod is locked by a ball clutch mechanism in the position of maximum inward movement. Thereafter maximum wind speed or pressure readings may be taken from calibrated indexing means

Proceedings of the 2nd Annual Workshop on Meteorological and Environmental Inputs to Aviation Systems

The proceedings of a workshop held at the University of Tennessee Space Institute, Tullahoma, Tennessee, March 28-30, 1978, are reported. The workshop was jointly sponsored by NASA, NOAA, FAA, and brought together many disciplines of the aviation communities in round table discussions. The major objectives of the workshop are to satisfy such needs of the sponsoring agencies as the expansion of our understanding and knowledge of the interactions of the atmosphere with aviation systems, as the better definition and implementation of services to operators, and as the collection and interpretation of data for establishing operational criteria, relating the total meteorological inputs from the atmospheric sciences to the needs of aviation communities

Automatic signal range selector for metering devices Patent

Voltage range selection apparatus for sensing and applying voltages to electronic instruments without loading signal sourc

Arm cavity resonant sideband control for laser interferometric gravitational wave detectors

We present a new optical control scheme for a laser interferometric gravitational wave detector that has a high degree of tolerance to interferometer spatial distortions and noise on the input light. The scheme involves resonating the rf sidebands in an interferometer arm cavity

The Skepticism of Anatole France

When Anatole France died 1n 1924, he had the satisfaction of knowing that he had lived long enough to enjoy the honors which are not usually bestowed upon men until their death. His long life filled with years of labor and earnest endeavor to improve the lives of his fellow-men, through a better adjustment to society, culminated in his election to the French Academy. By some critics he has been called the greatest writer of today. It is difficult to tell exactly upon what merits this distinction is based. Anatole France was not content to simply call himself a skeptic. On the contrary we find in him a curious combination of novelist, historian and critic. His works show an interest in many literary activities. In La Vie Litteraire he reveals himsel as a lover of ancient literation. In L\u27histoire Contermporaine and L\u27eglise et la Republique he is an anti-clerical and supporter of the seperation of Churcn and State; a bitter critic of all dogma. In Crainquebille we see him as the Socialist and champion of the rights of the people, and in Vere Les Tempa Mellicum and Sur La Pierre Blanche he is the optimist, strongly confident in a future Utopia. Probably it is in the realm of social satire that he can make his greatest claim to fame. So elusive is France in his feelings that his readers are not certain whether his is an intense interest in society or a context for it. Whatever we may think, we cannot deny that it is a strong feeling against what he calls evils of the day -- the church, politics, class inequalities, and many others which gave birth to such novels as L\u27Histoire Contemporaire, Sur La Pierre Blanche, and the little story Crainquebille. The strange combination of feelings which France arouses added to the fact that he is still a contemporary, makes it difficult to assign him any definite place in literature. So strong are his feelings that they dominate the contents of his work, and his satire is abundant in contradictions. Difficult as it may be to assign him a niche in literature, it cannot be denied that as a sincere disciple of justice and liberty, he has left a deep influence on France

Model of Thermal Wavefront Distortion in Interferometric Gravitational-Wave Detectors I: Thermal Focusing

We develop a steady-state analytical and numerical model of the optical response of power-recycled Fabry-Perot Michelson laser gravitational-wave detectors to thermal focusing in optical substrates. We assume that the thermal distortions are small enough that we can represent the unperturbed intracavity field anywhere in the detector as a linear combination of basis functions related to the eigenmodes of one of the Fabry-Perot arm cavities, and we take great care to preserve numerically the nearly ideal longitudinal phase resonance conditions that would otherwise be provided by an external servo-locking control system. We have included the effects of nonlinear thermal focusing due to power absorption in both the substrates and coatings of the mirrors and beamsplitter, the effects of a finite mismatch between the curvatures of the laser wavefront and the mirror surface, and the diffraction by the mirror aperture at each instance of reflection and transmission. We demonstrate a detailed numerical example of this model using the MATLAB program Melody for the initial LIGO detector in the Hermite-Gauss basis, and compare the resulting computations of intracavity fields in two special cases with those of a fast Fourier transform field propagation model. Additional systematic perturbations (e.g., mirror tilt, thermoelastic surface deformations, and other optical imperfections) can be included easily by incorporating the appropriate operators into the transfer matrices describing reflection and transmission for the mirrors and beamsplitter.Comment: 24 pages, 22 figures. Submitted to JOSA