SARS-CoV-2 Infection in Multiple Sclerosis

To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. Retrospective and multicenter registry in patients with MS with suspected or confirmed COVID-19 diagnosis and available disease course (mild = ambulatory; severe = hospitalization; and critical = intensive care unit/death). Cases were analyzed for associations between MS characteristics and COVID-19 course and for identifying risk factors for a fatal outcome. Of the 326 patients analyzed, 120 were cases confirmed by real-time PCR, 34 by a serologic test, and 205 were suspected. Sixty-nine patients (21.3%) developed severe infection, 10 (3%) critical, and 7 (2.1%) died. Ambulatory patients were higher in relapsing MS forms, treated with injectables and oral first-line agents, whereas more severe cases were observed in patients on pulsed immunosuppressors and critical cases among patients with no therapy. Severe and critical infections were more likely to affect older males with comorbidities, with progressive MS forms, a longer disease course, and higher disability. Fifteen of 33 patients treated with rituximab were hospitalized. Four deceased patients have progressive MS, 5 were not receiving MS therapy, and 2 were treated (natalizumab and rituximab). Multivariate analysis showed age (OR 1.09, 95% CI, 1.04-1.17) as the only independent risk factor for a fatal outcome. This study has not demonstrated the presumed critical role of MS therapy in the course of COVID-19 but evidenced that people with MS with advanced age and disease, in progressive course, and those who are more disabled have a higher probability of severe and even fatal diseas

El lenguaje escrito : el Quijote en la escuela

Realizado en el colegio público El Otero en Guardo (Palencia) por parte del claustro de profesores. El objetivo general es mejorar la ortografía y expresión escrita del alumnado a través del conocimiento de El Quijote. Las actividades desarrolladas han sido: conocimiento de El Quijote a través de distintas ediciones, participación en el concurso organizado por la Organización Nacional de Ciegos Españoles con motivo del IV centenario de El Quijote, taller de plástica relacionado con el tema. Así mismo el desarrollo del proyecto ha permitido organizar dos ponencias en las que ha intervenido María Dolores Rius abordando cómo trabajar la ortografía desde infantil hasta sexto curso de primaria facilitándo materiales, lo que ha contribuido a la formación del profesorado y a una mejor adecuación del proyecto al alumnado. Trabajo no publicado.Junta de Castilla y LeónCastilla y LeónConsejería de Educación. Dirección General de Universidades e Investigación; Monasterio de Nuestra Señora de Prado, Autovía Puente Colgante, s. n.; 47071 Valladolid; Tel. +34983411881; Fax +34983411939ES