Longitudinal Analysis Of Patents On Colorectal Cancer

Colorectal cancer is epidemiologically relevant worldwide because it is the fourth leading cause of death from cancer. This study aims to present the mapping of technologies related to colorectal cancer. The search took place during the months of May and June 2019. The Leans database was used, which collects global patent information. The search occurred through the term "colorectal cancer", inserted in the title or abstract fields. Patents with publication date between January 1, 2000 and June 1, 2019 were selected. Only the patents granted and those filed were filtered (patent application; granted patent). A total of 6,850 patents were identified, of which 5,445 (79.48%) correspond to patents filed and 1,405 (20.51%) are patents granted in the period from 2000 to 2019. In 2000, 47 patents on colorectal cancer were published. The quantitative growth of technologies filed and granted was constant. In 2017 there was a total of 911 applications, indicating a growth of 1938.29% in relation to the year 2000. The first patent of the period was on the APC gene mutation, associated with colorectal cancer in families of Ashkenazi Jews, developed by Laken and collaborators (2000), and belongs to Johns Hopkins University, Baltimore, Maryland, in the United States. It can be concluded that the mapping of patents is important to trace a panorama of the world technological advance, as well as it can also be used as an instrument to identify scientific articles that cite patents developed in a given time space

Mental health and workers in the context of the COVID-19 pandemic: an international literature Survey

In March 2020, the World Health Organization (WHO) declared that Covid-19 reached a pandemic level. In this regard, quarantine measures were applied by governmental organizations. Such measures had a negative impact on the mental health of the whole population, and thus, of the workers. This study aims to survey the international literature on aspects of mental health in workers in the context of the Covid-19 pandemic, available in the Scopus database. The methodology used is classified as exploratory, descriptive, and quantitative with a bibliometric approach. After searching and applying inclusion and exclusion criteria, a total of 217 documents were retrieved. For analysis, 7 thematic axes were organized, pointing out the main findings of each topic. As results, it was found that there is an important academic production on mental health aspects of health professionals, and less investigations with workers from other contexts. Still, it was identified that Brazilian researchers have played an important role in the production of this knowledge. It is concluded that the entire scientific community is engaged, especially in the health field, to conduct investigations addressing aspects of mental health and workers in the context of the Covid-19 pandemic

Evaluation of resistance genes and virulence factors in a food isolated Enterococcus durans with potential probiotic effect

AbstractEnterococci belong to the lactic acid bacteria (LAB) group, which are often considered to provide benefit to the host organism when consumed. However, these microorganisms have a potential as infective agents, being necessary to evaluate the presence of virulence factors and resistance to antibiotics to warrant the safe use of new strains as probiotic cultures. This study aimed to detect genes of potential virulence factors related with adhesion, aggregation, biofilm formation and resistance to vancomycin, in addition to evaluate the antibiotic susceptibility and adhesion capacity of Enterococcus durans LA18s, a strain previously isolated from Minas Frescal cheese. The PCR reactions with specific primers to detect genes of adhesion collagen protein (ace), aggregation substances (agg and asa), bopA (putative glycosyltransferase), bopB (beta-phosphoglucomutase), bopC (aldose 1-epimerase), and bopD (sugar-binding transcriptional regulator) were negative for E. durans LAB18s. In addition, the strain did not present the resistance genes vanA, vanC1 and vanC2/3, and exhibited sensibility to antibiotics commonly used in animal feed, such as erythromycin, tetracycline, vancomycin, gentamicin and penicillin. This strain also showed a strong capacity of biofilm formation and exhibited satisfactory auto-aggregative and hydrophobicity features. The results suggest that this strain can be safely used in animal feed