La Dominica Potestas en Roma y su proyección actual.

El texto desarrollado está dividido en dos partes, la primera referida a la Dominica Potestas en Roma y la segunda etapa es atinente a la Dominica Potestas y su Proyección Actual, en la cual se exterioriza la abolición de la esclavitud en la Argentina y su ilicitud, a través de la trata de personas la cual se configura por diversas manifestaciones, producidas por hechos a nivel laboral, sexual, religiosos, extracción de órganos, entre otros.AbstractThe text is divided into two parts, the first referring to the Dominica potestas in Rome and the second stage is with regard to the Dominica potestas and its current projection, in which externalises the abolition of slavery in Argentina and its illegality, through trafficking of people, which is configured by various manifestations, produced by facts in the workplace, sexual, religious, removal of organs, among others.Key words: Slavery; Freedom; Abolish; Subjugation; Republic; Life; Death

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective