Creación, gestión y uso de objetos de aprendizaje en la Web

El proyecto “Creación, Gestión y Uso de objetos de Aprendizaje en un Entorno Web” se ha desarrollado en la asignatura Sistemas Informáticos. Tiene como objetivo la puesta en producción de la versión 1.0 del Museo Virtual García Santesmases de la Facultad de Informática de la Universidad Complutense de Madrid. Este proyecto se centra en la construcción de una herramienta que sirva para la creación y gestión de recursos educativos, Objetos de Aprendizaje, modulares que puedan ser utilizados por diversos sistemas de enseñanza. Los Objetos de Aprendizaje creados con la herramienta a la que se refiere este proyecto están basados en los objetos del museo de informática García Santesmases, por lo que también se pueden utilizar como elementos de un museo virtual. [ABSTRACT] The proyect called “Creation, Management and Use of Learning Objects in the Web” has been developed into the subject “Sistemas Informáticos”. The main target is the setting in production of the 1.0 version of the “Virtual García Santesmases Museum” located at the School of Computer Science of the Complutense University of Madrid. This project focuses in the construction of a tool to be useful in the creation and management of educational resources, Learning Objects, modular Objects that they may be used by various tuitional systems. The Learning Objects created with the tool that this project refers to itself are based in the objects of García Santesmases Museum, so that also they can utilize themselves like elements of a virtual museum

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality