Numerical analysis of a new cross-flow type hydraulic turbine for high head and low flow rate

Cross-flow turbines have recently been proposed for energy recovery in aqueducts when the outlet pressure is greater than zero, owing to their constructive simplicity and good efficiency within a large range of flow rates and head drops. In the case of high head drop (higher than 150 m) and relatively small discharge (lower than 0.2 m3/s), the traditional design of these turbines leads to very small widths of the nozzle and the runner; as a consequence, friction losses grow dramatically and efficiency drops down to very low values. Standard Pelton turbines require zero outlet pressure and cannot be used as alternatives. A new counter-pressure hydraulic turbine for high head and low flow rate, called the High Power Recovery System (H-PRS) is proposed. H-PRS presents a different geometry to reduce friction losses inside the nozzle and the runner by widening the two external walls. Several curved baffles are proposed to guide the fluid particles inside the nozzle and to guarantee the right velocity direction at the inlet surface of the runner. Computational Fluid Dynamics (CFD) 3D transient analyses are carried out to measure H-PRS efficiency for different operating conditions and to compute its characteristic curve for different positions of the regulating flap

Inflammatory mediators as biomarkers in brain disorders.

Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby to validate the clinical diagnosis with pathological results. Biomarkers are valuable indicators for detecting different phases of a disease such as prevention, early onset, treatment, progression, and monitoring the effect of pharmacological responses to a therapeutic intervention. Inflammation occurs in neurodegenerative diseases, and identification and validation of molecules involved in this process could be a strategy for finding new biomarkers. The ideal inflammatory biomarker needs to be easily measurable, must be reproducible, not subject to wide variation in the population, and unaffected by external factors. Our review summarizes the most important inflammation biomarkers currently available, whose specificity could be utilized for identifying and monitoring distinctive phases of different neurodegenerative diseases

A close connection: Alzheimer’s disease and type 2 diabetes

In the recent years a growing body of evidence links insulin resistance and insulin action to neurodegenerative diseases, especially Alzheimer’s disease (AD). The importance of insulin in ageing as well as its role in cognition and other aspects of normal brain functions are well established. The hippocampus and cerebral cortex-distributed insulin and insulin receptor (IR) have been shown to be involved in brain cognitive functions. Conversely, deterioration of IR signaling is involved in agingrelated brain degeneration such as in AD and cognitive impairment in type 2 diabetes patients. Insulin administration, while maintaining euglycemia, improves memory in both healthy adults and Alzheimer’s disease patients. In the present review, some common links between AD and type 2 diabetes are presented. Furthermore, several biochemical aspects existing in both pathologies are highlighted

Systemic Immune Responses in Alzheimer’s Disease: In Vitro Mononuclear Cell Activation and Cytokine Production

To investigate the systemic signs of immune-inflammatory responses in Alzheimer’s disease (AD), in the present study we have analyzed blood lymphocyte subsets and the expression of activation markers on peripheral blood mononuclear cells (PBMCs) fromADpatients and age-matched healthy controls (HC) activated in vitro by recombinant amyloid-β peptide (rAβ42). Our study of AD lymphocyte subpopulations confirms the already described decrease of the absolute number and percentage of B cells when compared to HC lymphocytes, whereas the other subsets are not significantly different in patients and controls. We report the increased expression of the activation marker CD69 and of the chemokine receptors CCR2 and CCR5 on T cells but no changes of CD25 after activation. B cells are also activated by rAβ42 as demonstrated by the enhanced expression of CCR5. Moreover, rAβ42 induces an increased expression of the scavenger receptor CD36 on monocytes. Some activation markers and chemokine receptors are overexpressed in unstimulated AD cells when compared to controls. This is evidence of the pro-inflammatory status of AD. Stimulation by rAβ42 also induces the production of the pro-inflammatory cytokines IL-1β, IL-6, IFN-γ, and TNF-α, and of the anti-inflammatory cytokines IL-10 and IL-1Ra. The chemokines RANTES, MIP-1β, and eotaxin as well as some growth factors (GM-CSF, G-CSF) are also overproduced by AD-derived PBMC activated by rAβ42. These results support the involvement of systemic immunity in AD patients. However, our study is an observational one so we cannot draw a conclusion about its contribution to the pathophysiology of the disease

A New Cross-Flow Type Turbine for Ultra-Low Head in Streams and Channels

In the last few decades, hydropower production has been moving toward a new paradigm of low and diffused power density production of energy with small and mini-hydro plants, which usually do not require significant water storage. In the case of nominal power lower than 20 kW and ultra-low head H (H < 5 m), Archimedes screw or Kaplan type turbines are usually chosen due to their efficiency, which is higher than 0.85. A new cross-flow type turbine called Ultra-low Power Recovery System (UL-PRS) is proposed and its geometry and design criteria are validated in a wide range of operating conditions through 2D numerical analysis computed using the ANSYS Fluent solver. The new proposed solution is much simpler than the previously mentioned competitors; its outlet flow has a horizontal direction and attains similar efficiency. The costs of the UL-PRS turbine are compared with the costs of one Kaplan and one cross-flow turbine (CFT) in the case study of the main water treatment plant of the city of Palermo in Italy. In this case, the UL-PRS efficiency is estimated using a URANS 3D numerical analysis computed with the CFX solver

Design of Reliable and Efficient Banki-Type Turbines

A new shape for the external surface of the Crossflow turbine blades is proposed, which allows for the preservation of hydraulic efficiency in spite of a significant maximum blade thickness providing mechanic robustness and reliability. The final shape of the blades is assessed using an iterative solution for two uncoupled models: a 2D computational fluid dynamic (CFD) and a structural 3D finite element method (FEM) analysis of a single blade. Application of the proposed methodology to the design of a power recovery system (PRS) turbine, a new backpressure Crossflow-type inline turbine for pressure regulation, and energy production in a real Sicilian site follows

Low-Head Hydropower for Energy Recovery in Wastewater Systems

Hydraulic turbines for energy recovery in wastewater treatment plants, with relatively large discharges values and small head jumps, are usually screw Archimedes or Kaplan types. In the specific case of a small head jump (about 3 m) underlying a rectangular weir in the major Palermo (Italy) water treatment plant, a traditional Kaplan solution is compared with two other new proposals: a Hydrostatic Pressure Machine (HPM) located at the upstream channel and a cross-flow turbine (CFT) located in a specific underground room downstream of the same channel. The fluid mechanical formulations of the flow through these turbines are analyzed and the characteristic parameters are stated. Numerical analysis was carried out for the validation of the HPM design criteria. The efficiency at the design point of the CFT and HPM are estimated using the ANSYS CFX solver for resolution of 3D URANS analysis. The strong and weak points of the three devices are compared. Finally, a viability analysis is developed based on several economic indicators. This innovative study with a theoretical formulation of the most suitable turbomachine characterization, the potential energy estimation based on hydraulic energy recovery in a real case study of a wastewater treatment plant and the comparison of the three different low-head turbines, enhancing the main advantages, is of utmost importance towards the net-zero water sector decarbonization