In the recent years a growing body of evidence
links insulin resistance and insulin action to
neurodegenerative diseases, especially Alzheimer’s
disease (AD). The importance of insulin in ageing
as well as its role in cognition and other aspects of
normal brain functions are well established. The
hippocampus and cerebral cortex-distributed insulin
and insulin receptor (IR) have been shown to be
involved in brain cognitive functions. Conversely,
deterioration of IR signaling is involved in agingrelated
brain degeneration such as in AD and
cognitive impairment in type 2 diabetes patients.
Insulin administration, while maintaining
euglycemia, improves memory in both healthy
adults and Alzheimer’s disease patients. In the
present review, some common links between AD
and type 2 diabetes are presented. Furthermore,
several biochemical aspects existing in both
pathologies are highlighted