3 research outputs found
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Poly(vinyl alcohol)–Gantrez® AN cryogels for wound care applications
Cryotropic gelation is a low cost, well-known technique that has been used for decades for the preparation of cryogels based on poly(vinyl alcohol). This technique does not require addition of any cross-linkers or initiators because a physical cross-linking takes place during the cryotropic gelation. Poly(vinyl alcohol)–Gantrez® AN cryogels with highly porous structure were successfully produced from the aqueous polymer mixtures with addition of 0.4, 0.6 and 0.8% w/v NaOH, which were frozen at −18 °C for approximately 9 hours and then thawed at room temperature (∼25 °C). These cryogels exhibited excellent mechanical properties (with 158–218% elongation to break) and high swelling ability in water (∼40 g of deionized water could be absorbed per 1 g of initial gel within 48 h). They exhibited intrinsic antimicrobial properties against Staphylococcus aureus without the addition of any antimicrobial agent due to the acidic nature of Gantrez® AN and related low pH of these cryogels. The in vitro biocompatibility of these cryogels was assessed using human dermal fibroblasts with very encouraging results. These cryogels are promising for applications in wound care
Inter- and intra-varietal genetic varibility in Malvasia cultivars
The DNA molecular analyses together with ampelography, ampelometry, and biochemistry are essentiaor grapevine identification and investigation of genetic differences among the Vitis vinifera L. cultivars and clones. Ten Malvasia cultivars (i.e., Istrian Malvasia; M. delle Lipari; M. bianca di Candia; M. di Candia Aromatica; M. del Lazio; M. bianca lunga, also known as Malvasia del Chianti; M. nera di Brindisi/Lecce; M. di Casorzo; M. di Schierano, and M. nera di Bolzano) were analyzed using molecular approaches to study the genetic inter-varietal variability. Thirty Istrian Malvasia genotypes (i.e., 8 Italian clones, such as ISV 1, ISV F6, VCR 4, VCR 113, VCR 114, VCR 115, ERSA 120, ERSA 121, and 22 autochthonous grapevine accessions grown in Istrian Peninsula, Croatia) were investigated to evaluate the morphological and genetic intra-varietal variability. DNA analysis allowed discrimination of all Malvasia genotypes at molecular level using AFLP, SAMPL, and M-AFLP markers. Italian clones and autochthonous Croatian accessions of Istrian Malvasia were grouped according to their different geographic origins. These results showed the great genetic variability of Malvasia genotypes suggesting the need for the preservation of autochthonous grapevine biotypes found on different areas to approve the correct choice and selection of the grape multiplication material
Synthesis, biological evaluation and docking studies of a novel class of sulfur-bridged diazabicyclo[3.3.1]nonanes
A small library of 3-thia-7,9-diazabicyclo[3.3.1]nonanes was synthesized and their opioid receptors affinity and
selectivity evaluated. Among these novel sulfur-bridged compounds, the (E) 9-[3\u2032-(3-chlorophenyl)-but-2\u2032-en-1\u2032-
yl]-7-propionyl-3-thia-7,9-diazabicyclo[3.3.1]nonane 2i emerged as the derivative with the highest \u3bc receptor
affinity (Ki = 85 nM) and selectivity (Ki \u3bc/\u3b4 = 58.8, Ki \u3bc/\u3ba > 117.6). The antinociceptive activity of 2i was
also evaluated in acute thermal pain. Docking studies disclosed the specific pattern of interactions of these
derivatives