Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50μgml−1) and 5.09% at the highest concentration (200μgml−1). Conclusions: Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system

Preparation and Carbonization of Glucose and Pyromellitic Dianhydride Crosslinked Polymers

In this work, four types of nanosponges were prepared from pyromellitic dianhydride (PMDA) and D-glucose (GLU) with different molar ratios (1.5:1, 2:1, 2.5:1 and 3:1). The obtained PMDA/GLU nanosponges were then pyrolyzed at 800 °C for 30 min under N2 gas flow. The prepared polymeric nanosponges were investigated by FTIR spectroscopy, elemental and thermogravimetric analyses to unravel the role played by the different molar ratio of the precursors in the formation of the polymer. The pyrolyzed nanosponges were investigated by means of porosity measurements, X-ray diffraction analysis, Raman spectroscopy and high-resolution transmission electron microscopy. Notably, no significant correlation of the amounts of used precursors with the porous texture and structure was evidenced. The results corroborate that PMDA and GLU can be easily combined to prepare nanosponges and that the carbon materials produced by their pyrolysis can be associated with glassy carbons with a microporous texture and relatively high surface area. Such hard carbons can be easily obtained and shrewdly used to segregate relatively small molecules and organic contaminants; in this study methylene blue adsorption was investigated

Techno-economic comparison of buildings acting as Single-Self Consumers or as energy community through multiple economic scenarios

The European Union has set ambitious targets to move towards a society with high penetration of renewable energy sources. In the forthcoming energy transition, Energy Communities (EC), i.e., legal entities where different actors, including citizens, cooperate in energy generation, storage and management, will play a crucial role. The present work simulates the energy flows and assesses the potential economic benefits of a cluster of buildings acting collectively as an energy community – a specific case study is set in northern Italy by comparing the EC performance with a configuration where customers act as Single Self-Consumers (SSCs). Pending the transposition of EU Directives to binding national laws, due by 2021, different supporting tariffs (economic scenarios) have been simulated in order to determine which scheme will support more effectively the integration of Energy Communities in the national energy market. Results show that ECs (i.e., customers acting collectively as energy prosumers) are able to accelerate the diffusion of building-integrated renewable energy sources (RES), resulting in higher overall self-consumption rates than SSCs. Self-consumed electricity generates savings on the energy bill of EC, and we calculated positive economic performance indicators for all the analysed economic scenarios. The sensitivity analysis carried out on system and transport charges of the electricity bill shows their remarkable impact on the economics making the EC less attractive for investors and citizens without proper supporting schemes

Key economic drivers enabling municipal renewable energy communities’ benefits in the Italian context

Community energy is a buzzword that has historically included various type of experiences. In 2018, the Renewable Energy Directive (RED II) legally defined renewable energy communities (RECs). Based on the first pilot projects and on the Italian legal framework, a possible REC configuration of municipal initiative with a high replicability potential is one in which a photovoltaic system is installed in educational buildings and shares energy with neighbouring residential consumers. This analysis presents an economical evaluation of different possible scenarios depending on variables such as solar radiation, system capacity, fraction of self-consumption within the REC, installation costs and energy prices. All the scenarios identified and analysed show positive economic indexes, although the energy and economic results may significantly vary depending on the variables studied. In the analysed case studies, the Net Present Value (after 20 years) is between kEUR 51 and kEUR 478; the internal rate of return is between 9.5% and 88%; the payback time is between 13.6 years and 1.1 years. The results of this analysis are relevant as they allow us to better understand the critical factors that can enable REC in providing local economic and social benefits to have a real impact on energy poverty or on the provision of local social services

On the interactions of melatonin/β-cyclodextrin inclusion complex: A novel approach combining efficient semiempirical extended tight-binding (xtb) results with ab initio methods

Melatonin (MT) is a molecule of paramount importance in all living organisms, due to its presence in many biological activities, such as circadian (sleep–wake cycle) and seasonal rhythms (reproduction, fattening, molting, etc.). Unfortunately, it suffers from poor solubility and, to be used as a drug, an appropriate transport vehicle has to be developed, in order to optimize its release in the human tissues. As a possible drug-delivery system, β-cyclodextrin (βCD) represents a promising scaffold which can encapsulate the melatonin, releasing when needed. In this work, we present a computational study supported by experimental IR spectra on inclusion MT/βCD complexes. The aim is to provide a robust, accurate and, at the same time, low-cost methodology to investigate these inclusion complexes both with static and dynamic simulations, in order to study the main actors that drive the interactions of melatonin with β-cyclodextrin and, therefore, to understand its release mechanism

On the interactions of melatonin/β-cyclodextrin inclusion complex: A novel approach combining efficient semiempirical extended tight-binding (xtb) results with ab initio methods

Melatonin (MT) is a molecule of paramount importance in all living organisms, due to its presence in many biological activities, such as circadian (sleep–wake cycle) and seasonal rhythms (reproduction, fattening, molting, etc.). Unfortunately, it suffers from poor solubility and, to be used as a drug, an appropriate transport vehicle has to be developed, in order to optimize its release in the human tissues. As a possible drug-delivery system, β-cyclodextrin (βCD) represents a promising scaffold which can encapsulate the melatonin, releasing when needed. In this work, we present a computational study supported by experimental IR spectra on inclusion MT/βCD complexes. The aim is to provide a robust, accurate and, at the same time, low-cost methodology to investigate these inclusion complexes both with static and dynamic simulations, in order to study the main actors that drive the interactions of melatonin with β-cyclodextrin and, therefore, to understand its release mechanism