GeoNode per la gestione di dati aziendali e territoriali nella Precision Farming in Veneto

A giugno 2017 l\u2019Universit\ue0 degli Studi di Padova, attraverso il sostegno della Regione Veneto nell\u2019ambito di un bando POR-FSE, ha dato avvio al progetto \u201cDroni in viticoltura e frutticoltura: geo-informazione per agroecosistemi 4.0 in Veneto e Trentino\u201d della durata di un anno. L\u2019obiettivo di tale progetto era di introdurre l\u2019impiego delle nuove tecnologie quali SAPR, immagini satellitari e sistemi informativi geografici all\u2019interno delle aziende agricole in modo tale da consentire lo sviluppo della cosiddetta \u201cagricoltura di precisione\u201d. Nell\u2019ambito di questo progetto si inserisce la creazione di un webGIS articolato su diverse scale di inquadramento: una scala territoriale ed una aziendale. I dati necessari alla costruzione del progetto sono stati perlopi\uf9 ricercati nel web in database gratuiti offerti da Enti pubblici regionali e nazionali. Nell\u2019ambito dei webGIS territoriali sono stati inoltre inseriti dati provenienti da rilievi APR eseguiti per il monitoraggio dello stato di salute delle colture delle aziende partner del progetto. L\u2019analisi dei dati raccolti e la costruzione del progetto \ue8 avvenuta in ambiente GIS utilizzando software open-source quali QGIS 2.18 per l\u2019elaborazione dei dati raccolti e personali ed uDig 2.0 per la vestizione dei diversi tematismi in modo tale da consentire il caricamento di dati gi\ue0 stilizzati all\u2019interno del webGIS. I servizi erogati dal webGIS territoriale offrono, attraverso carte tematiche, una panoramica del territorio veneto nella sua complessit\ue0, comprendendo sia gli aspetti naturali/ambientali, sia quelli legati all\u2019attivit\ue0 dell\u2019uomo. A questa panoramica si affiancano i webGIS aziendali, nei quali ciascuna azienda pu\uf2 consultare i propri dati, confrontandosi tra l\u2019altro con le realt\ue0 circostanti

Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation

Circadian disruption negatively affects physiology, posing a global health threat that manifests in proliferative, metabolic, and immune diseases, among others. Because outputs of the circadian clock regulate daily fluctuations in the immune response, we determined whether circadian disruption results in tumor-associated immune cell remodeling, facilitating tumor growth. Our findings show that tumor growth rate increased and latency decreased under circadian disruption conditions compared to normal light-dark (LD) schedules in a murine melanoma model. Circadian disruption induced the loss or inversion of daily patterns of M1 (proinflammatory) and M2 (anti-inflammatory) macrophages and cytokine levels in spleen and tumor tissues. Circadian disruption also induced (i) deregulation of rhythmic expression of clock genes and (ii) of cyclin genes in the liver, (iii) increased CcnA2 levels in the tumor, and (iv) dampened expression of the cell cycle inhibitor p21WAF/CIP1, all of which contribute to a proliferative phenotype.Fil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Virginia Tech University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mul Fedele, Malena Lis. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Román, F.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Marpegan, Luciano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Caldart Valle, Carlos Sebastian. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Finkielstein, C.V.. Virginia Tech University; Estados UnidosFil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Epidemiology of ovine toxoplasmosis and neosporosis in rams from Rio Grande do Sul, Brazil.

Although the State of Rio Grande do Sul is one of the principal sheep rearing regions in Brazil, the prevalence of Toxoplasma gondii and Neospora caninum is unknown in rams. The objective of this study was to determine the prevalence of ovine toxoplasmosis and neosporosis and the risk factors associated with the development of these diseases in rams used exclusively for breeding.September 23-28, 2018

Neutralising reactivity against SARS-CoV-2 delta and omicron variants by vaccination and infection history.

BACKGROUND: The continuous emergence of SARS-CoV-2 variants of concern (VOC) with immune escape properties, such as Delta (B.1.617.2) and Omicron (B.1.1.529), questions the extent of the antibody-mediated protection against the virus. Here we investigated the long-term antibody persistence in previously infected subjects and the extent of the antibody-mediated protection against B.1, B.1.617.2 and BA.1 variants in unvaccinated subjects previously infected, vaccinated naïve and vaccinated previously infected subjects. METHODS: Blood samples collected 15 months post-infection from unvaccinated (n=35) and vaccinated (n=41) previously infected subjects (Vo' cohort) were tested for the presence of antibodies against the SARS-CoV-2 spike (S) and nucleocapsid (N) antigens using the Abbott, DiaSorin, and Roche immunoassays. The serum neutralising reactivity was assessed against B.1, B.1.617.2 (Delta), and BA.1 (Omicron) SARS-CoV-2 strains through micro-neutralisation. The antibody titres were compared to those from previous timepoints, performed at 2- and 9-months post-infection on the same individuals. Two groups of naïve subjects were used as controls, one from the same cohort (unvaccinated n=29 and vaccinated n=20) and a group of vaccinated naïve healthcare workers (n=61). RESULTS: We report on the results of the third serosurvey run in the Vo' cohort. With respect to the 9-month time point, antibodies against the S antigen significantly decreased (P=0.0063) among unvaccinated subjects and increased (P<0.0001) in vaccinated individuals, whereas those against the N antigen decreased in the whole cohort. When compared with control groups (naïve Vo' inhabitants and naïve healthcare workers), vaccinated subjects that were previously infected had higher antibody levels (P<0.0001) than vaccinated naïve subjects. Two doses of vaccine elicited stronger anti-S antibody response than natural infection (P<0.0001). Finally, the neutralising reactivity of sera against B.1.617.2 and BA.1 was 4-fold and 16-fold lower than the reactivity observed against the original B.1 strain. CONCLUSIONS: These results confirm that vaccination induces strong antibody response in most individuals, and even stronger in previously infected subjects. Neutralising reactivity elicited by natural infection followed by vaccination is increasingly weakened by the recent emergence of VOCs. While immunity is not completely compromised, a change in vaccine development may be required going forward, to generate cross-protective pan-coronavirus immunity in the global population