Seroprevalence, clinical and biochemical data of dogs naturally infected by Leishmania and phlebotominae sandfly fauna in an endemic area in São Luis Island, Maranhão State, Brazil

Submitted by Sandra Infurna ([email protected]) on 2019-04-04T10:59:38Z No. of bitstreams: 1 KatiaS_Calabrese_etal_IOC_2008.pdf: 107712 bytes, checksum: 218d62edcf8ffe6857c3d47f249e7030 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2019-04-04T11:20:28Z (GMT) No. of bitstreams: 1 KatiaS_Calabrese_etal_IOC_2008.pdf: 107712 bytes, checksum: 218d62edcf8ffe6857c3d47f249e7030 (MD5)Made available in DSpace on 2019-04-04T11:20:28Z (GMT). No. of bitstreams: 1 KatiaS_Calabrese_etal_IOC_2008.pdf: 107712 bytes, checksum: 218d62edcf8ffe6857c3d47f249e7030 (MD5) Previous issue date: 2008Universidade Estadual do Maranhão. Departamento de Patologia. São Luis, MA, Brasil.Universidade Estadual do Maranhão. São Luiz, MA, Brasil.Universidade Estadual do Maranhão. São Luiz, MA, Brasil.Universidade Estadual do Maranhão. São Luiz, MA, Brasil.Sem afiliaçãoSem afiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Maranhão. Departamento de Patologia. São Luis, MA, Brasil.Universidade Estadual do Maranhão. Departamento de Patologia. São Luis, MA, Brasil.Universidade Estadual do Maranhão. Departamento de Patologia. São Luis, MA, Brasil.The aim of this study was to determine the seroprevalence, clinical and biochemical profile of Leishmania chagasi infection in dogs naturally infected and identify the phlebotominae fauna in an endemic area of São Luis Island. In this present study, 62 household mongrel dogs were sampled for antibodies anti-Leishmania. The seroprevalence was 51.61%. In the clinical evaluation, 36.68% dogs were symptomatic, 38.41% were oligosymptomatic and 26.13% were asymptomatic. The most frequent signs were onychogryphosis and lymphadenomegaly. In 29.41% animals were observed anemia. In the biochemical analysis hepatic function showed changes in relation to alaninoaminotransferase (ALT) and aspartato aminotransferase (AST). Urea values were higher than the references ones for canine specie. The following phlebotominae sandflies were identified: Lutzomyia longipalpis (86.9%), L. evandroi (9.6%), L. choti (2.1%), L. umbratilis (0.7%) e L. whitmani (0.7%)

Os objetos epistêmicos das toxoplasmoses e suas reapresentações em um congresso científico internacional The epistemic objects of toxoplasmoses and their re-presentation in an international scientific conference

O artigo investiga os objetos epistêmicos do Toxoplasma gondii e a correlação de forças de grupos de pesquisa empenhados em reconfigurar a toxoplasmose. A pesquisa de dados e a análise foram conduzidas à luz dos conceitos de 'manipulação' e 'reeencenação', com base na ideia de 'dramatização' proposta por Mol em estudo de filosofia empírica. Constatou-se que os objetos foram reapresentados a partir de matizes diversificados e com forte vinculação ao complexo industrial. Por sua projeção nos rumos da economia mundial no século XXI, a genética foi importante protagonista dos debates sobre causalidade única, uma das convicções da ciência ocidental.<br>The paper investigates the epistemic objects of Toxoplasma gondii and the correlation of forces of research groups committed to redefine or reconfigure toxoplasmosis. The data research and this analysis were conducted in a scientific congress, according to the concepts of 'manipulation' and 'reenactment,' based on the idea of 'dramatization' proposed by Mol in a study of empirical philosophy. It was found that the objects were represented from diversified hues and with strong ties to the industrial complex. For its projection in the trends of the global economy in the twenty-first century, genetics was a major protagonist in the debates on sole causality, one of the convictions of Western science

Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries

Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide.Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters.Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries.Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)