2,697 research outputs found
Update on quetiapine in the treatment of bipolar disorder: results from the BOLDER studies
The essential features of bipolar affective disorder involve the cyclical occurrence of high (manic or hypomanic episodes) and low mood states. Depressive episodes in both bipolar I and II disorder are more numerous and last for longer duration than either manic or hypomanic episodes. In addition depressive episodes are associated with higher morbidity and mortality. While multiple agents, including all 5 atypical antipsychotics, have demonstrated efficacy and earned US FDA indication for manic phase of bipolar illness, the acute treatment of bipolar depression is less well-studied. The first treatment approved by the US FDA for acute bipolar depression was the combination of the atypical antipsychotic olanzapine and the antidepressant fluoxetine. Recently, quetiapine monotherapy has demonstrated efficacy in the treatment of depressive episodes associated with both bipolar I and II disorder and has earned US FDA indication for the same
Moving black holes via singularity excision
We present a singularity excision algorithm appropriate for numerical
simulations of black holes moving throughout the computational domain. The
method is an extension of the excision procedure previously used to obtain
stable simulations of single, non-moving black holes. The excision procedure
also shares elements used in recent work to study the dynamics of a scalarfield
in the background of a single, boosted black hole. The robustness of our
excision method is tested with single black-hole evolutions using a coordinate
system in which the coordinate location of the black hole, and thus the
excision boundary, moves throughout the computational domain.Comment: 9 pages and 11 figure
The discrete energy method in numerical relativity: Towards long-term stability
The energy method can be used to identify well-posed initial boundary value
problems for quasi-linear, symmetric hyperbolic partial differential equations
with maximally dissipative boundary conditions. A similar analysis of the
discrete system can be used to construct stable finite difference equations for
these problems at the linear level. In this paper we apply these techniques to
some test problems commonly used in numerical relativity and observe that while
we obtain convergent schemes, fast growing modes, or ``artificial
instabilities,'' contaminate the solution. We find that these growing modes can
partially arise from the lack of a Leibnitz rule for discrete derivatives and
discuss ways to limit this spurious growth.Comment: 18 pages, 22 figure
Mental Health Over Time in a Military Sample: The Impact of Alcohol Use Disorder on Trajectories of Psychopathology After Deployment
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116086/1/jts22055.pd
Divergent Directionality of Immune Cell-Specific Protein Expression between Bipolar Lithium Responders and Non-Responders Revealed by Enhanced Flow Cytometry
Background and Objectives: There is no biomarker to predict lithium response. This study used CellPrint™ enhanced flow cytometry to study 28 proteins representing a spectrum of cellular pathways in monocytes and CD4+ lymphocytes before and after lithium treatment in patients with bipolar disorder (BD). Materials and Methods: Symptomatic patients with BD type I or II received lithium (serum level ≥ 0.6 mEq/L) for 16 weeks. Patients were assessed with standard rating scales and divided into two groups, responders (≥50% improvement from baseline) and non-responders. Twenty-eight intracellular proteins in CD4+ lymphocytes and monocytes were analyzed with CellPrint™, an enhanced flow cytometry procedure. Data were analyzed for differences in protein expression levels. Results: The intent-to-treat sample included 13 lithium-responders (12 blood samples before treatment and 9 after treatment) and 11 lithium-non-responders (11 blood samples before treatment and 4 after treatment). No significant differences in expression between the groups was observed prior to lithium treatment. After treatment, the majority of analytes increased expression in responders and decreased expression in non-responders. Significant increases were seen for PDEB4 and NR3C1 in responders. A significant decrease was seen for NR3C1 in non-responders. Conclusions: Lithium induced divergent directionality of protein expression depending on the whether the patient was a responder or non-responder, elucidating molecular characteristics of lithium responsiveness. A subsequent study with a larger sample size is warranted
Subthreshold PTSD and PTSD in a prospective‐longitudinal cohort of military personnel: Potential targets for preventive interventions
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146501/1/da22819_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146501/2/da22819.pd
Precision Epoch of Reionization studies with next-generation CMB experiments
Future arcminute resolution polarization data from ground-based Cosmic
Microwave Background (CMB) observations can be used to estimate the
contribution to the temperature power spectrum from the primary anisotropies
and to uncover the signature of reionization near in the small
angular-scale temperature measurements. Our projections are based on combining
expected small-scale E-mode polarization measurements from Advanced ACTPol in
the range with simulated temperature data from the full Planck
mission in the low and intermediate region, . We show that
the six basic cosmological parameters determined from this combination of data
will predict the underlying primordial temperature spectrum at high multipoles
to better than accuracy. Assuming an efficient cleaning from
multi-frequency channels of most foregrounds in the temperature data, we
investigate the sensitivity to the only residual secondary component, the
kinematic Sunyaev-Zel'dovich (kSZ) term. The CMB polarization is used to break
degeneracies between primordial and secondary terms present in temperature and,
in effect, to remove from the temperature data all but the residual kSZ term.
We estimate a detection of the diffuse homogeneous kSZ signal from
expected AdvACT temperature data at , leading to a measurement of
the amplitude of matter density fluctuations, , at precision.
Alternatively, by exploring the reionization signal encoded in the patchy kSZ
measurements, we bound the time and duration of the reionization with
and . We find that
these constraints degrade rapidly with large beam sizes, which highlights the
importance of arcminute-scale resolution for future CMB surveys.Comment: 10 pages, 10 figure
Investigating the structural compaction of biomolecules upon transition to the gas-phase using ESI-TWIMS-MS
Collision cross-section (CCS) measurements obtained from ion mobility spectrometry-mass spectrometry (IMS-MS) analyses often provide useful information concerning a protein’s size and shape and can be complemented by modeling procedures. However, there have been some concerns about the extent to which certain proteins maintain a native-like conformation during the gas-phase analysis, especially proteins with dynamic or extended regions. Here we have measured the CCSs of a range of biomolecules including non-globular proteins and RNAs of different sequence, size, and stability. Using traveling wave IMS-MS, we show that for the proteins studied, the measured CCS deviates significantly from predicted CCS values based upon currently available structures. The results presented indicate that these proteins collapse to different extents varying on their elongated structures upon transition into the gas-phase. Comparing two RNAs of similar mass but different solution structures, we show that these biomolecules may also be susceptible to gas-phase compaction. Together, the results suggest that caution is needed when predicting structural models based on CCS data for RNAs as well as proteins with non-globular folds
Universal corrections to entanglement entropy of local quantum quenches
We study the time evolution of single interval Renyi and entanglement entropies following local quantum quenches in two dimensional conformal field theories at finite temperature for which the locally excited states have a finite temporal width, \epsilon. We show that, for local quenches produced by the action of a conformal primary field, the time dependence of Renyi and entanglement entropies at order \epsilon^2 is universal. It is determined by the expectation value of the stress tensor in the replica geometry and proportional to the conformal dimension of the primary field generating the local excitation. We also show that in CFTs with a gravity dual, the \epsilon^2 correction to the holographic entanglement entropy following a local quench precisely agrees with the CFT prediction. We then consider CFTs admitting a higher spin symmetry and turn on a higher spin chemical potential \mu. We calculate the time dependence of the order \epsilon^2 correction to the entanglement entropy for small \mu, and show that the contribution at order \mu^2 is universal. We verify our arguments against exact results for minimal models and the free fermion theory
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