Adolf Reinach: An Intellectual Biography

The essay provides an account of the development of Reinach’s philosophy of “Sachverhalte” (states of affairs) and on problems in the philosophy of law, leading up to his discovery of the theory of speech acts in 1913. Reinach’s relations to Edmund Husserl and to the Munich phenomenologists are also dealt with

Review of economic evidence in the prevention and early detection of colorectal cancer.

This paper aims to systematically review the cost-effectiveness evidence, and to provide a critical appraisal of the methods used in the model-based economic evaluation of CRC screening and subsequent surveillance. A search strategy was developed to capture relevant evidence published 1999-November 2012. Databases searched were MEDLINE, EMBASE, National Health Service Economic Evaluation (NHS EED), EconLit, and HTA. Full economic evaluations that considered costs and health outcomes of relevant intervention were included. Sixty-eight studies which used either cohort simulation or individual-level simulation were included. Follow-up strategies were mostly embedded in the screening model. Approximately 195 comparisons were made across different modalities; however, strategies modelled were often simplified due to insufficient evidence and comparators chosen insufficiently reflected current practice/recommendations. Studies used up-to-date evidence on the diagnostic test performance combined with outdated information on CRC treatments. Quality of life relating to follow-up surveillance is rare. Quality of life relating to CRC disease states was largely taken from a single study. Some studies omitted to say how identified adenomas or CRC were managed. Besides deterministic sensitivity analysis, probabilistic sensitivity analysis (PSA) was undertaken in some studies, but the distributions used for PSA were rarely reported or justified. The cost-effectiveness of follow-up strategies among people with confirmed adenomas are warranted in aiding evidence-informed decision making in response to the rapidly evolving technologies and rising expectations

Children’s travel as pedestrians: an international survey of policy and practice

A survey of OECD member countries was carried out to provide high level data on a consistent basis to identify and account for current patterns of child road safety . This paper reports the findings relating to children, aged 0-14 years, as pedestrians. Key survey elements included analyses of fatality data, relationships between socio-economic, demographic factors and fatality rates, and a questionnaire based survey. League tables based on average child pedestrian fatality rates were constructed for each OECD member country participating in our questionnaire enabling identification of the top five countries with the lowest pedestrian fatality rate as Sweden, The Netherlands, Finland, Germany, and Denmark. Few countries had quantitative information about children’s travel and its absence means that assessments are difficult about children’s safety and the relative risks they face, especially as pedestrians. There are large variations in the amount of walking between countries and growing car use is becoming an issue in one third of OECD countries. The main findings from the questionnaire survey were that the majority of countries did not have information on high risk groups but of those that did, the cross cutting themes of socio-economic and ethnic minority groups, young children and urban areas were identified. Three characteristics distinguish top countries in the League table from those doing less well: a strong approach to the introduction of infrastructure measures for pedestrian safety, including low speed limits in residential areas; conducting road safety campaigns at least once a year; and having legislation which assumes driver responsibility in an accident involving a child pedestrian. Having compulsory road safety education for children aged 6-9 years was a characteristic shared by most countries, as was the promotion of child pedestrian education and training initiatives and the commissioning of research. However there is lower research activity in less well performing countries

Analysis of secondary cells with lithium anodes and immobilized fused-salt electrolytes

Secondary cells with liquid lithium anodes, liquid bismuth or tellurium cathodes, and fused lithium halide electrolytes immobilized as rigid pastes operate between 380 and 485 degrees. Applications include power sources in space, military vehicle propulsion and special commercial vehicle propulsion

Social Justice, The Common Weal and Children and Young People in Scotland

This paper argues that: • Scotland should organise itself around social justice, which addresses entitlements, redistribution, recognition and respect. • Children and young people have particular views on what social justice means for them. • Rights have a particular contribution to make to social justice in term of entitlements, claims and minimal standards. • The combination of piecemeal incorporation of children’s rights, an apolitical wellbeing framework and a lack of strong legislation to hold local authorities and other public services, private sector organisations and the third sector to account, results in children and young people encountering discrimination on an everyday basis. • To achieve social justice, a change is needed in how adults perceive children and childhood, young people and youth. Children and young people need to be recognised as contributors to their families, institutions and communities now – and not just in the future. • For children and young people to be included in the Common Weal, it needs to be concerned with the full and diverse range of structural, cultural and individual barriers that they encounter in their lives

Improving the usability of the hierarchical file system

Whether you are interested in improving the usability of Linux, Macintosh or Windows, there is one restriction you cannot escape - the hierarchical file storage system. The notion of files and folders has been with us for so long that it almost seems axiomatic. In this paper we look at the effects on users of forcing a hierarchical classification of files. We also consider how some of the resultant problems can be tackled with a new piece of file browsing software based on the ideas of relational database systems

On the estimation of temporal mileage rates

Peer reviewedPostprin

Self-replication and evolution of DNA crystals

Is it possible to create a simple physical system that is capable of replicating itself? Can such a system evolve interesting behaviors, thus allowing it to adapt to a wide range of environments? This paper presents a design for such a replicator constructed exclusively from synthetic DNA. The basis for the replicator is crystal growth: information is stored in the spatial arrangement of monomers and copied from layer to layer by templating. Replication is achieved by fragmentation of crystals, which produces new crystals that carry the same information. Crystal replication avoids intrinsic problems associated with template-directed mechanisms for replication of one-dimensional polymers. A key innovation of our work is that by using programmable DNA tiles as the crystal monomers, we can design crystal growth processes that apply interesting selective pressures to the evolving sequences. While evolution requires that copying occur with high accuracy, we show how to adapt error-correction techniques from algorithmic self-assembly to lower the replication error rate as much as is required