1 research outputs found
Visible-Light-Responsive Surfaces for Efficient, Noninvasive Cell Sheet Harvesting
Effective regulation
of cell-surface interactions is critical for regenerative medicine
and other cell-based therapies. Herein, visible-light-induced cell
sheet harvesting based on silicon wafers with a p/n junction [SiĀ(p/n)]
is introduced. Cell sheets could quickly detach from the SiĀ(p/n) surface
after 10 min of visible-light illumination with maintained cell viability
and functions. It is found that preadsorbed proteins on the SiĀ(p/n)
surface like BSA and collagen-I show light-induced desorption behaviors.
Molecular dynamics simulation also indicates that long-range force
caused by the photovoltaic effect of SiĀ(p/n) under visible-light illumination
plays a key role in triggering the release of the preadsorbed protein.
It is suggested that such protein desorption behavior mediated by
the photovoltaic effect is responsible for cell release. This work
not only shows promising potential for cell sheet harvesting, but
also provides new insights into proteināmaterial interactions