Rethinking Cross-Domain Pedestrian Detection: A Background-Focused Distribution Alignment Framework for Instance-Free One-Stage Detectors

Cross-domain pedestrian detection aims to generalize pedestrian detectors from one label-rich domain to another label-scarce domain, which is crucial for various real-world applications. Most recent works focus on domain alignment to train domain-adaptive detectors either at the instance level or image level. From a practical point of view, one-stage detectors are faster. Therefore, we concentrate on designing a cross-domain algorithm for rapid one-stage detectors that lacks instance-level proposals and can only perform image-level feature alignment. However, pure image-level feature alignment causes the foreground-background misalignment issue to arise, i.e., the foreground features in the source domain image are falsely aligned with background features in the target domain image. To address this issue, we systematically analyze the importance of foreground and background in image-level cross-domain alignment, and learn that background plays a more critical role in image-level cross-domain alignment. Therefore, we focus on cross-domain background feature alignment while minimizing the influence of foreground features on the cross-domain alignment stage. This paper proposes a novel framework, namely, background-focused distribution alignment (BFDA), to train domain adaptive onestage pedestrian detectors. Specifically, BFDA first decouples the background features from the whole image feature maps and then aligns them via a novel long-short-range discriminator.Comment: This paper published on IEEE Transactions on Image Processing on August 2023.See https://ieeexplore.ieee.org/document/1023112

Knowledge and risk behaviors related to HIV/AIDS, and their association with information resource among men who have sex with men in Heilongjiang province, China

<p>Abstract</p> <p>Backgroud</p> <p>In Heilongjiang province, the HIV prevalence in men who have sex with men (MSM) is generally lower than other part of China. However, the official perception for their risk of HIV/AIDS infection has been increasing in the province over the years. Moreover, little information on HIV/AIDS was provided to the communities so that we have disadvantage of controlling HIV/AIDS epidemic in the region. The purpose of this study is to investigate the prevalence of HIV among MSM in Heilongjiang province, to assess their knowledge levels and risk behaviors related to HIV/AIDS, and to explore their associations with information resources.</p> <p>Methods</p> <p>A cross-sectional study using a standardized questionnaire and blood test was administered in 2008 by local interviewers to a sample (1353) of MSM in four cities in Heilongjiang province.</p> <p>Results</p> <p>Among 1353 MSM, 2.3% were identified with HIV infection. About 48.7% of the subjects had multiple male sexual partners and only 37.3% of the subjects had consistent condom use (use every time) in the past 6 months. Most had a fair level of knowledge on HIV/AIDS, with the highest mean knowledge score among the MSM from Jiamusi, those with income 2000-3000 RMB/month, those searching sexual partners via internet and those performed HIV testing over 1 year ago). However, some myths regarding viral transmission (e.g., via mosquito bites or sharing kitchen utensils) also existed. Resources of information from which knowledge and risk behaviors related to HIV/AIDS was most available were television (58.6%) among MSM, followed by sexual partner (51.6%), publicity material (51.0%) and internet (48.7%). Significantly statistical differences of mean knowledge score were revealed in favor of book (<it>P </it>= 0.0002), medical staff (<it>P </it>= 0.0007), publicity material (<it>P </it>= 0.005) and sexual partner (<it>P </it>= 0.02). Press (<it>P </it>= 0.04) and book (<it>P </it>= 0.0003) were contributory to the most frequent condom use (condom use every time), while medical staff (<it>P </it>= 0.005) and publicity material (<it>P </it>= 0.04) is associated with moderate rate of condom use (condom use often).</p> <p>Conclusions</p> <p>Although the prevalence of HIV infection is low among MSM in Heilongjiang province, the situation that the risk behaviors were frequent in the population is alarming. The study suggests that some strategies like condom use and education intervention are practical approaches and need to be strengthened.</p

Association of lipoprotein lipase (LPL) gene variants with hyperlipidemic acute pancreatitis in southeastern Chinese population

ABSTRACT Objective: The study aims to explore the relationship between lipoprotein lipase (LPL) variants and hyperlipidemic acute pancreatitis (HLAP) in the southeastern Chinese population. Subjects and methods: In total, 80 participants were involved in this study (54 patients with HLAP and 26 controls). All coding regions and intron-exon boundaries of the LPL gene were sequenced. The correlations between variants and phenotypes were also analysed. Results: The rate of rare LPL variants in the HLAP group is 14.81% (8 of 54), higher than in controls. Among the detected four variants (rs3735959, rs371282890, rs761886494 and rs761265900), the most common variant was rs371282890. Further analysis demonstrated that subjects with rs371282890 "GC" genotype had a 2.843-fold higher risk for HLAP (odds ratio [OR]: 2.843, 95% confidence interval [CI]: 1.119-7.225, p = 0.028) than subjects with the "CC" genotype. After adjusting for sex, the association remained significant (adjusted OR: 3.083, 95% CI: 1.208-7.869, p = 0.018). Subjects with rs371282890 "GC" genotype also exhibited significantly elevated total cholesterol, triglyceride and non-high-density lipoprotein cholesterol levels in all the participants and the HLAP group (p < 0.05). Conclusion: Detecting rare variants in LPL might be valuable for identifying higher-risk patients with HLAP and guiding future individualised therapeutic strategies

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

SummarySomatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors. However, the low efficiency and slow kinetics of the reprogramming process have hampered progress with this technology. Here we report that a natural compound, vitamin C (Vc), enhances iPSC generation from both mouse and human somatic cells. Vc acts at least in part by alleviating cell senescence, a recently identified roadblock for reprogramming. In addition, Vc accelerates gene expression changes and promotes the transition of pre-iPSC colonies to a fully reprogrammed state. Our results therefore highlight a straightforward method for improving the speed and efficiency of iPSC generation and provide additional insights into the mechanistic basis of the reprogramming process

Bolted connections of cold-formed stainless steel at elevated temperatures and post-fire condition

The structural behaviour of single shear bolted connections and double shear bolted connections of cold-formed stainless steel at elevated temperatures and post-fire condition has been investigated in this study. The current design rules on bolted connections of cold-formed stainless steel are mainly based on those of carbon steel, and are applicable for room (ambient) temperature condition only. These design rules may not be applicable for elevated temperatures. Therefore, design guidelines should be prepared for bolted connections of cold-formed stainless steel structures at elevated temperatures. The key findings of the investigation are described in the following paragraphs. A total of 25 tensile coupon tests were conducted to investigate the material deterioration of three different grades of stainless steel at elevated temperatures. The stainless steels are austenitic stainless steel EN 1.4301 (AISI 304) and EN 1.4571 (AISI 316Ti having small amount of titanium) as well as lean duplex stainless steel EN 1.4162 (AISI S32101). Totally 434 tests on bolted connections of stainless steel were performed in the temperature ranged from 22 to 950 ºC using both steady state and transient state test methods. The test results were compared with the nominal strengths calculated from the American Specification, Australian/New Zealand Standard and European codes for stainless steel structures. In calculating the nominal strengths of the connections, the material properties at elevated temperatures were used in the design equations for room temperature. It is shown that the nominal strengths predicted by these specifications are generally conservative at elevated temperatures. A total of 78 cold-formed stainless steel single shear and double shear bolted connections were tested in post-fire condition. The test results were compared with those tested at room temperature. Generally, it is found that the bolted connection strengths in post-fire condition cooling down from 350 and 650 ºC are higher than those tested at room temperature for all three grades of stainless steel. Finite element models for single shear and double shear bolted connections were developed and verified against the experimental results. Static analysis technique was used in the numerical analyses. Extensive parametric studies that included 450 specimens were performed using the verified finite element models to evaluate the bearing resistances of bolted connections of stainless steel at elevated temperatures. Design equations for bearing resistances of cold-formed stainless steel single shear and double shear bolted connections were proposed based on both the experimental and numerical results in the temperature ranged from 22 to 950 ºC. The bearing resistances of bolted connections obtained from the tests and the finite element analyses were compared with the nominal strengths calculated using the current design rules and also compared with the predicted strengths calculated using the proposed design equations. It is shown that the proposed design equations are generally more accurate and reliable in predicting the bearing resistances of bolted connections at elevated temperatures than the current design rules. The reliability of the current and proposed design rules was evaluated using reliability analysis. The proposed design equations are recommended for bolted connections assembled using cold-formed stainless steels.published_or_final_versionCivil EngineeringDoctoralDoctor of Philosoph

Recent Research Advances in High-Performance Steel Tubular Members: Material Properties, Stub Columns, and Beams

This paper presents recent advances in research on high-performance steel tubular members, including beams and columns. The term high-performance steel has been used for steels that have unparalleled characteristics such as high strength, cold formability, corrosion resistance, and ductility. Stainless steel (SS) and high-strength steel (HSS) are classified as high-performance steel. In the context of this paper, high-performance steel refers to SS and HSS, where HSS is with a nominal yield strength equal to or higher than 690 MPa. This paper initially illustrates the applications of high-performance steel as a construction material for buildings and infrastructures. Subsequently, the material properties of high-performance steel with constitutive models in response to the stress–strain curves are summarized. Furthermore, this paper reviews research on the structural performance of high-performance steel stub columns and beams and presents the associated design equations. Finally, insights into future work on the structural behavior of high-performance steel to promote its widespread use for building and infrastructure construction are provided

Behaviour of duplex stainless steel bolted connections

This study deals with the behaviour of duplex stainless steel bolted connections. The aim of the study is to respond to the question if the current stainless steel design specifications are able to predict the behaviour of such connections. Firstly, the net cross-section capacity of duplex stainless steel plates subjected to tensile loading are presented. They were conducted to obtain the stress–strain curves and tensile fracture behaviour used to support the finite element (FE) fracture simulations. Secondly, nonlinear FE models are developed for duplex stainless steel bolted connections subjected to tensile loading. The FE models are validated against experimental data in terms of load–displacement curves, failure modes and ultimate loads. Then, a numerical parametric study that consists of 133 duplex stainless steel grade EN 1.4162 bolted connection specimens is carried out. The failure modes of bolted connections are carefully examined, including combined tear out and bearing, bearing and net section, looking at the influence of parameters such as end distance, edge distance and spacing between the bolts in the connections. The results are compared to the design rules prescribed in the current stainless steel design specifications. Generally, it is found that the Australian/New Zealand (AS/NZS), American (SEI/ASCE) Specification and European codes conservatively predict the ultimate strengths of the bolted connections, whereas the strengths predicted by the AS/NZS and SEI/ASCE specifications are overall more accurate and less scattered

Behaviour of duplex stainless steel bolted connections

This study deals with the behaviour of duplex stainless steel bolted connections. The aim of the study is torespond to the question if the current stainless steel design specifications are able to predict the behaviourof such connections. Firstly, the net cross-section capacity of duplex stainless steel plates subjected to tensileloading are presented. They were conducted to obtain the stress–strain curves and tensile fracture behaviourused to support the finite element (FE) fracture simulations. Secondly, nonlinear FE models are developedfor duplex stainless steel bolted connections subjected to tensile loading. The FE models are validated againstexperimental data in terms of load–displacement curves, failure modes and ultimate loads. Then, a numericalparametric study that consists of 133 duplex stainless steel grade EN 1.4162 bolted connection specimens iscarried out. The failure modes of bolted connections are carefully examined, including combined tear out andbearing, bearing and net section, looking at the influence of parameters such as end distance, edge distance andspacing between the bolts in the connections. The results are compared to the design rules prescribed in thecurrent stainless steel design specifications. Generally, it is found that the Australian/New Zealand (AS/NZS),American (SEI/ASCE) Specification and European codes conservatively predict the ultimate strengths of thebolted connections, whereas the strengths predicted by the AS/NZS and SEI/ASCE specifications are overallmore accurate and less scattered