Comparison of different signal processing algorithms to extract the respiration waveform from the ECG

Power spectral analysis of heart rate variability is a powerful tool to measure the activity of the parasympathetic division of the autonomic nervous system noninvasively. To determine the parasympathetic activity, the frequency of respiration must be known. However, during ambulatory studies, the frequency of respiration is not acquired. To alleviate this problem, methods have been proposed in the past to derive the respiration from the ECG. Unfortunately, these previous methods are unreliable if the subject\u27s breathing rate is uncontrolled. In this study, four methods to derive the respiration waveform from the electrocardiogram (ECG) were developed. Two leads of ECG and a measure of respiration were taken from nine healthy subjects during rest, paced breathing, and exercise. To determine the optimum method, the respiration was then derived using all four methods and compared to the measured respiration in the time domain and frequency domain using cross-correlation and coherence, respectively. The results of this study indicate that three of the four methods developed can accurately and reliably derive the respiration during every section of the experimental protocol. In addition, the respiration waveform derived using the variable QRS window, dependent leads method is quantitatively identified as the most accurate

EVALUATION OF THERMAL AND MECHANICAL PROPERTIES OF DEMONSTRATION WALL UTILIZING PHASE CHANGE CEMENTITIOUS MATERIALS

International project PoroPCM involves partners from Germany, Czech Republic, Spain and Japan with the objective to develop new multifunctional Phase Change Materials modified porous cementitious nanocomposite (PoroPCM). Such material can be utilized for storing heat energy in the insulation layer of buildings compared to commonly used insulation materials since the phase change increases heat capacity. This enhanced feature reduces the amount of energy necessary for running the heating/cooling system. For the testing of the newly developed phase change cementitious composite a demonstration wall will be developed and tested for its thermal as well as mechanical performance. The topic of the paper is the description of the properties of the new phase change cementitious nanocomposite. The main emphasis of the paper is the description of the demonstration wall behaviour under typical environmental conditions. The wall design is supported by numerical simulation of the wall physical parameters. The numerical modelling involves the definition of suitable numerical models for the simulation of the thermal properties of the new phase change nanocomposite. The numerical model is then used to demonstrate the performance of the wall layer design. The presented pilot results show efficiency increase of the insulation material in the range 15–70%. Also modelling of wind resistance of the layered structure is included. The developed wall design and PoroPCM material will be tested and verified by a large scale test in the final year of the project

Optimizing Inventory in a Multi-Echelon Multi-Item Supply Chain with Time-Based Customer Service Level Agreements

Optimizing Inventory in a Multi-Echelon Multi-Item Supply Chain with Time-Based Customer Service Level Agreement

Particle decay branching ratios for states of astrophysical importance in 19Ne

We have measured proton and alpha-particle branching ratios of excited states in 19Ne formed using the 19F(3He,t) reaction at a beam energy of 25 MeV. These ratios have a large impact on the astrophysical reaction rates of 15O(alpha,gamma), 18F(p,gamma) and 18F(p,alpha), which are of interest in understanding energy generation in x-ray bursts and in interpreting anticipated gamma-ray observations of novae. We detect decay protons and alpha-particles using a silicon detector array in coincidence with tritons measured in the focal plane detector of our Enge split-pole spectrograph. The silicon array consists of five strip detectors of the type used in the Louvain-Edinburgh Detector Array, subtending angles from 130 degrees to 165 degrees with approximately 14% lab efficiency. The correlation angular distributions give additional confidence in some prior spin-parity assignments that were based on gamma branchings. We measure Gamma_p/Gamma=0.387+-0.016 for the 665 keV proton resonance, which agrees well with the direct measurement of Bardayan et al.Comment: 5 pages, 2 figures, 3 tables. Prepared using RevTex 4 and BibTex. Further minor revisions, incl. fig. 1 font size increase, 1 table removal, and minor changes to the tex

Absolute Determination of the 22Na(p,g) Reaction Rate in Novae

Gamma-ray telescopes in orbit around the Earth are searching for evidence of the elusive radionuclide 22Na produced in novae. Previously published uncertainties in the dominant destructive reaction, 22Na(p,g)23Mg, indicated new measurements in the proton energy range of 150 to 300 keV were needed to constrain predictions. We have measured the resonance strengths, energies, and branches directly and absolutely by using protons from the University of Washington accelerator with a specially designed beamline, which included beam rastering and cold vacuum protection of the 22Na implanted targets. The targets, fabricated at TRIUMF-ISAC, displayed minimal degradation over a ~ 20 C bombardment as a result of protective layers. We avoided the need to know the stopping power, and hence the target composition, by extracting resonance strengths from excitation functions integrated over proton energy. Our measurements revealed that resonance strengths for E_p = 213, 288, 454, and 610 keV are stronger by factors of 2.4 to 3.2 than previously reported. Upper limits have been placed on proposed resonances at 198-, 209-, and 232-keV. We have re-evaluated the 22Na(p,g) reaction rate, and our measurements indicate the resonance at 213 keV makes the most significant contribution to 22Na destruction in novae. Hydrodynamic simulations including our rate indicate that the expected abundance of 22Na ejecta from a classical nova is reduced by factors between 1.5 and 2, depending on the mass of the white-dwarf star hosting the nova explosion.Comment: 20 pages, 18 figures; shortened paper, accepted in Phys. Rev.

Suppressed-scattering spectral windows for radiative cooling applications

The scattering of light by resonant nanoparticles is a key process for enhancing the solar reflectance in daylight radiative cooling. Here, we investigate the impact of material dispersion on the scattering performance of popular nanoparticles for radiative cooling applications. We show that, due to material dispersion, nanoparticles with a qualitatively similar response at visible frequencies exhibit fundamentally different scattering properties at infrared frequencies. It is found that dispersive nanoparticles exhibit suppressed-scattering windows, allowing for selective thermal emission within a highly reflective sample. The existence of suppressed-scattering windows solely depends on material dispersion, and they appear pinned to the same wavelength even in random composite materials and periodic metasurfaces. Finally, we investigate calcium-silicate-hydrate (CSH), the main phase of concrete, as an example of a dispersive host, illustrating that the co-design of nanoparticles and host allows for tuning of the suppressed-scattering windows. Our results indicate that controlled nanoporosities would enable concrete with daylight passive radiative cooling capabilities

Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates

Human growth hormone (hGH) is a pituitary-derived endocrine protein that regulates several critical postnatal physiologic processes including growth, organ development, and metabolism. Following adulthood, GH is also a regulator of multiple pathologies like fibrosis, cancer, and diabetes. Therefore, there is a significant pharmaceutical interest in developing antagonists of hGH action. Currently, there is a single FDA-approved antagonist of the hGH receptor (hGHR) prescribed for treating patients with acromegaly and discovered in our laboratory almost 3 decades ago. Here, we present the first data on the structure and function of a new set of protein antagonists with the full range of hGH actions—dual antagonists of hGH binding to the GHR as well as that of hGH binding to the prolactin receptor. We describe the site-specific PEG conjugation, purification, and subsequent characterization using MALDI-TOF, size-exclusion chromatography, thermostability, and biochemical activity in terms of ELISA-based binding affinities with GHR and prolactin receptor. Moreover, these novel hGHR antagonists display distinct antagonism of GH-induced GHR intracellular signaling in vitro and marked reduction in hepatic insulin-like growth factor 1 output in vivo. Lastly, we observed potent anticancer biological efficacies of these novel hGHR antagonists against human cancer cell lines. In conclusion, we propose that these new GHR antagonists have potential for development towards multiple clinical applications related to GH-associated pathologies.</p