306 research outputs found

    In-Vessel Coil Material Failure Rate Estimates for ITER Design Use

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    The ITER international project design teams are working to produce an engineering design for construction of this large tokamak fusion experiment. One of the design issues is ensuring proper control of the fusion plasma. In-vessel magnet coils may be needed for plasma control, especially the control of edge localized modes (ELMs) and plasma vertical stabilization (VS). These coils will be lifetime components that reside inside the ITER vacuum vessel behind the blanket modules. As such, their reliability is an important design issue since access will be time consuming if any type of repair were necessary. The following chapters give the research results and estimates of failure rates for the coil conductor and jacket materials to be used for the in-vessel coils. Copper and CuCrZr conductors, and stainless steel and Inconel jackets are examined

    Review of Maintenance and Repair Times for Components in Technological Facilities

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    This report is a compilation of some unique component repair time data and it also presents citations of more extensive reports where lists of repair times can be found. This collection of information should support analysts who seek to quantify maintainability and availability of high technology and nuclear energy production systems. While there are newer sources of repair time information, most, if not all, of the newer sources are proprietary and cannot be shared. This report offers data that, while older, is openly accessible and can serve as reasonable estimates of repair times, at least for initial studies. Some times were found for maintenance times in radiation environments, and some guidance for multiplicative factors to use to account for work in contamination areas

    The provenance, date and significance of a Cook-voyage Polynesian sculpture

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    A unique wooden sculpture collected by James Cook during his first voyage to the Pacific is widely considered to be a masterpiece of Oceanic art, but its exact provenance has been unclear. New analysis of shavings from the object now indicate that a) the tree from which it was carved was felled between 1690 and 1728, and that the carving was therefore up to 80 years old when obtained, and b) it originated in Tahiti, despite its stylistic affinities with art from the Austral Islands. Motifs and forms clearly travelled within regions, and populations interacted in ways that blur presumed tribal boundaries. It is perhaps time to reconsider the association between region and style upon which the cataloguing and identification of objects routinely depends.The research reported upon here has taken place in the context of two projects, 'Artefacts of Encounter', funded by the UK Arts and Humanities Research Council over 2010-13, and 'Pacific Presences', funded by the European Research Council over 2013-18. We are grateful to both agencies for their support. We also thank: Julie Adams (British Museum); Peter Brunt (Victoria University); Caroline Cartwright (British Museum); Steven Hooper (University of East Anglia); JeanYves Meyer (Ministère des Ressources Marines, des Mines et de la Recherche, Polynésie Française); Mark Nesbitt (Economic Botany Collection, Royal Botanic Gardens, Kew); Tamsin O’Connell (Dorothy Garrod Laboratory for Isotopic Analysis, McDonald Institute for Archaeological Research); Jessica Royles (Department of Plant Sciences, University of Cambridge); Matthew Spriggs (Australian National University); and the University of Oxford Radiocarbon Accelerator Unit

    Radiation Protection Instrument Reliability and Ma

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    This report is a collection of reliability and ma

    Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay.

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    Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population. To understand the mechanisms involved in maintaining satellite cell quiescence, we identified gene transcripts that were differentially expressed during satellite cell activation following muscle injury. Transcripts encoding RNA binding proteins were among the most significantly changed and included the mRNA decay factor Tristetraprolin. Tristetraprolin promotes the decay of MyoD mRNA, which encodes a transcriptional regulator of myogenic commitment, via binding to the MyoD mRNA 3' untranslated region. Upon satellite cell activation, p38α/β MAPK phosphorylates MAPKAP2 and inactivates Tristetraprolin, stabilizing MyoD mRNA. Satellite cell specific knockdown of Tristetraprolin precociously activates satellite cells in vivo, enabling MyoD accumulation, differentiation and cell fusion into myofibers. Regulation of mRNAs by Tristetraprolin appears to function as one of several critical post-transcriptional regulatory mechanisms controlling satellite cell homeostasis
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