Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval

Theoretical models of episodic memory have proposed that retrieval depends on interactions between the hippocampus and neocortex, where hippocampal reinstatement of item-context associations drives neocortical reinstatement of item information. Here, we simultaneously recorded intracranial EEG from hippocampus and lateral temporal cortex (LTC) of epilepsy patients who performed a virtual reality spatial navigation task. We extracted stimulus-specific representations of both item and item-context associations from the time-frequency patterns of activity in hippocampus and LTC. Our results revealed a double dissociation of representational reinstatement across time and space: an early reinstatement of item-context associations in hippocampus preceded a later reinstatement of item information in LTC. Importantly, reinstatement levels in hippocampus and LTC were correlated across trials, and the quality of LTC reinstatement was predicted by the magnitude of phase synchronization between hippocampus and LTC. These findings confirm that episodic memory retrieval in humans relies on coordinated representational interactions within a hippocampal-neocortical network.The research leading to these results has received funding from the ERC grant agreement n° 341196 (CDAC). N.A. received funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Projektnummer 316803389 – SFB 1280 as well as via Projektnummer 122679504 – SFB 874. M.S. received funding by Spanish National Project INSOCO-DPI2016-80116-P