Remote spectral imaging with simultaneous extraction of 3D topography for historical wall paintings

PRISMS (Portable Remote Imaging System for Multispectral Scanning) is designed for in situ, simultaneous high resolution spectral and 3D topographic imaging of wall paintings and other large surfaces. In particular, it can image at transverse resolutions of tens of microns remotely from distances of tens of metres, making high resolution imaging possible from a fixed position on the ground for areas at heights that is difficult to access. The spectral imaging system is fully automated giving 3D topographic mapping at millimetre accuracy as a by-product of the image focusing process. PRISMS is the first imaging device capable of both 3D mapping and spectral imaging simultaneously without additional distance measuring devices. Examples from applications of PRISMS to wall paintings at a UNESCO site in the Gobi desert are presented to demonstrate the potential of the instrument for large scale 3D spectral imaging, revealing faded writing and material identification

Knowledge-based identification of sleep stages based on two forehead electroencephalogram channels

© 2014 Huang, Lin, Ko, Liu, Su and Lin. Sleep quality is important, especially given the considerable number of sleep-related pathologies. The distribution of sleep stages is a highly effective and objective way of quantifying sleep quality. As a standard multi-channel recording used in the study of sleep, polysomnography (PSG) is a widely used diagnostic scheme in sleep medicine. However, the standard process of sleep clinical test, including PSG recording and manual scoring, is complex, uncomfortable, and time-consuming. This process is difficult to implement when taking the whole PSG measurements at home for general healthcare purposes. This work presents a novel sleep stage classification system, based on features from the two forehead EEG channels FP1 and FP2. By recording EEG from forehead, where there is no hair, the proposed system can monitor physiological changes during sleep in a more practical way than previous systems. Through a headband or self-adhesive technology, the necessary sensors can be applied easily by users at home. Analysis results demonstrate that classification performance of the proposed system overcomes the individual differences between different participants in terms of automatically classifying sleep stages. Additionally, the proposed sleep stage classification system can identify kernel sleep features extracted from forehead EEG, which are closely related with sleep clinician's expert knowledge. Moreover, forehead EEG features are classified into five sleep stages by using the relevance vector machine. In a leave-one-subject-out cross validation analysis, we found our system to correctly classify five sleep stages at an average accuracy of 76.7 ± 4.0 (SD) % [average kappa 0.68 ± 0.06 (SD)]. Importantly, the proposed sleep stage classification system using forehead EEG features is a viable alternative for measuring EEG signals at home easily and conveniently to evaluate sleep quality reliably, ultimately improving public healthcare

Age-related human small intestine methylation: evidence for stem cell niches

BACKGROUND: The small intestine is constructed of many crypts and villi, and mouse studies suggest that each crypt contains multiple stem cells. Very little is known about human small intestines because mouse fate mapping strategies are impractical in humans. However, it is theoretically possible that stem cell histories are inherently written within their genomes. Genomes appear to record histories (as exemplified by use of molecular clocks), and therefore it may be possible to reconstruct somatic cell dynamics from somatic cell errors. Recent human colon studies suggest that random somatic epigenetic errors record stem cell histories (ancestry and total numbers of divisions). Potentially age-related methylation also occurs in human small intestines, which would allow characterization of their stem cells and comparisons with the colon. METHODS: Methylation patterns in individual crypts from 13 small intestines (17 to 78 years old) were measured by bisulfite sequencing. The methylation patterns were analyzed by a quantitative model to distinguish between immortal or niche stem cell lineages. RESULTS: Age-related methylation was observed in the human small intestines. Crypt methylation patterns were more consistent with stem cell niches than immortal stem cell lineages. Human large and small intestine crypt niches appeared to have similar stem cell dynamics, but relatively less methylation accumulated with age in the small intestines. There were no apparent stem cell differences between the duodenum and ileum, and stem cell survival did not appear to decline with aging. CONCLUSION: Crypt niches containing multiple stem cells appear to maintain human small intestines. Crypt niches appear similar in the colon and small intestine, and the small intestinal stem cell mitotic rate is the same as or perhaps slower than that of the colon. Although further studies are needed, age-related methylation appears to record somatic cell histories, and a somatic epigenetic molecular clock strategy may potentially be applied to other human tissues to reconstruct otherwise occult stem cell histories

Fractional crystallization of monosulfide solid solution from sulfide liquids lead to the PGE enrichment in the Jinchuan Ni-Cu sulfide deposit, western China

Discordant lenses of Pt-Pd enriched zones (ores bearing up to 1.0 ppm of Pt or Pd) have recently been identified in the sulfide-bearing peridotite of the Jinchuan Cu-Ni-PGE (Platinum group element) sulfide deposit, China. Chalcopyrite, pyrrhotite, and pentlandite occur in both Pt-Pd enriched zones and normal ores, but Cu-bearing minerals such as cubanite and Bi-, Te-, and As-bearing minerals are more abundant in the Pt-Pd enriched zones. Sperrylite is the major Pt-host minerals in the Pt-Pd enriched zones interstinally and occurs mainly as euhedral grains within base-metal sulfides which occur among the cumulates of olivine. PGE-enrichment is found only in sulfide-bearing samples. In orebody # 1 and orebody 24, Rh, Ru, and Ir are positively correlated, but a negative Ir-Pd and Ir-Pt correlation. However in orebody 2 Rh, Ru, Pt, Pd and Ir are positively correlated. Taken together, the elemental correlations and mineralogical data support a model for the origin of Pt-Pd rich ores in Orebody 1 and Orebody 24 of the Jinchuan deposit are consistent with fractional crystallization of monosulfide solid solution from sulfide liquids on cooling; The origin of Orebody 2 involves variable magma/sulfide liquid mass ratios (R-factors).published_or_final_versio

Forehead EEG in Support of Future Feasible Personal Healthcare Solutions: Sleep Management, Headache Prevention, and Depression Treatment

© 2013 IEEE. There are current limitations in the recording technologies for measuring EEG activity in clinical and experimental applications. Acquisition systems involving wet electrodes are time-consuming and uncomfortable for the user. Furthermore, dehydration of the gel affects the quality of the acquired data and reliability of long-term monitoring. As a result, dry electrodes may be used to facilitate the transition from neuroscience research or clinical practice to real-life applications. EEG signals can be easily obtained using dry electrodes on the forehead, which provides extensive information concerning various cognitive dysfunctions and disorders. This paper presents the usefulness of the forehead EEG with advanced sensing technology and signal processing algorithms to support people with healthcare needs, such as monitoring sleep, predicting headaches, and treating depression. The proposed system for evaluating sleep quality is capable of identifying five sleep stages to track nightly sleep patterns. Additionally, people with episodic migraines can be notified of an imminent migraine headache hours in advance through monitoring forehead EEG dynamics. The depression treatment screening system can predict the efficacy of rapid antidepressant agents. It is evident that frontal EEG activity is critically involved in sleep management, headache prevention, and depression treatment. The use of dry electrodes on the forehead allows for easy and rapid monitoring on an everyday basis. The advances in EEG recording and analysis ensure a promising future in support of personal healthcare solutions

The landscape of viral associations in human cancers

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein–Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer

Luminescent properties of Bi-doped polycrystalline KAlCl4

We observed an intensive near-infrared luminescence in Bi-doped KAlCl4 polycrystalline material. Luminescence dependence on the excitation wavelength and temperature of the sample was studied. Our experimental results allow asserting that the luminescence peaked near 1 um belongs solely to Bi+ ion which isomorphically substitutes potassium in the crystal. It was also demonstrated that Bi+ luminescence features strongly depend on the local ion surroundings

Automatic Multi-source Data Fusion Technique of Powerline Corridor using UAV Lidar

China Southern Power Grid Key Technology of High Performance Integrated Small Intelligent Transmission UAV (GDKJXM20198187)

Cor Triatriatum Sinister diagnosed in adult life with three dimensional transesophageal echocardiography

<p>Abstract</p> <p>Background</p> <p>Cor triatriatum is a very rare congenital abnormality, usually symptomatic during childhood, diagnosis in adult age is less common.</p> <p>Case Presentation</p> <p>We report the case of a 40 years old woman referred to our hospital for atrial flutter ablation, transthoracic cardiac bidimensional echocardiography showed an abnormal membrane bisecting the left atrium, the diagnosis of cor triatriatum was fully made via three dimensional transesophageal echocardiography. More interstingly three other cardiac anomalies were associated: ostium secundum atrial septal defect, dilated coronary sinus due probably to persistent left superior vena cava and normally functioning bicuspid aortic valve.</p> <p>Conclusions</p> <p>Cor triatriatum sinister in adult life is important to recognize because it may be easily surgically correctable when hemodynamically significant. Three Dimensional transesophageal echocardiography is a minimally invasive and highly sensitive diagnostic modality.</p