Exact 1/N and Optimized Perturbative Evaluation of mu_c for Homogeneous Interacting Bose Gases

In the framework of the O(N) three-dimensional effective scalar field model for homogeneous dilute weakly interacting Bose gases we use the 1/N expansion to evaluate, within the large N limit, the parameter r_c which is directly related to the critical chemical potential mu_c. This quantity enters the order-a^2 n^{2/3} coefficient contributing to the critical temperature shift Delta T_c where a represents the s-wave scattering length and n represents the density. Compared to the recent precise numerical lattice simulation results, our calculation suggests that the large N approximation performs rather well even for the physical case N=2. We then calculate the same quantity but using different forms of the optimized perturbative (variational) method, showing that these produce excellent results both for the finite N and large-N cases.Comment: 12 pages, 2 figures. We have performed a refined and extended numerical analysis to take into account the very recent results of Ref. [15

Role of twin boundaries on the vortex dynamics in YBa2_2Cu3_3O7_7

By means of a novel technique of rotating the applied current we have directly measured the influence of twin boundaries on the vortex motion in a YBa$_2$Cu$_3$O$_7$ single crystal. The results indicate that the effect of twin planes on the vortex dynamics starts to develop below a certain temperature, being responsible for an anisotropic viscosity in the vortex liquid state and a guided motion in the solid state.Comment: 4 pages, 4 figure

Molecular Dynamics Simulation of Amyloid Beta Dimer Formation

Recent experiments with amyloid-beta (Abeta) peptide suggest that formation of toxic oligomers may be an important contribution to the onset of Alzheimer's disease. The toxicity of Abeta oligomers depends on their structure, which is governed by assembly dynamics. Due to limitations of current experimental techniques, a detailed knowledge of oligomer structure at the atomic level is missing. We introduce a molecular dynamics approach to study Abeta dimer formation: (1) we use discrete molecular dynamics simulations of a coarse-grained model to identify a variety of dimer conformations, and (2) we employ all-atom molecular mechanics simulations to estimate the thermodynamic stability of all dimer conformations. Our simulations of a coarse-grained Abeta peptide model predicts ten different planar beta-strand dimer conformations. We then estimate the free energies of all dimer conformations in all-atom molecular mechanics simulations with explicit water. We compare the free energies of Abeta(1-42) and Abeta(1-40) dimers. We find that (a) all dimer conformations have higher free energies compared to their corresponding monomeric states, and (b) the free energy difference between the Abeta(1-42) and the analogous Abeta(1-40) dimer conformation is not significant. Our results suggest that Abeta oligomerization is not accompanied by the formation of stable planar beta-strand Abeta dimers.Comment: 32 pages (preprint format), 3 figure

Coulomb Parameter U and Correlation Strength in LaFeAsO

First principles constrained density functional theory scheme in Wannier functions formalism has been used to calculate Coulomb repulsion U and Hund's exchange J parameters for iron 3d electrons in LaFeAsO. Results strongly depend on the basis set used in calculations: when O-2p, As-4p, and Fe-3d orbitals and corresponding bands are included, computation results in U=3-4 eV, however, with the basis set restricted to Fe-3d orbitals and bands only, computation gives parameters corresponding to F^0=0.8 eV, J=0.5 eV. LDA+DMFT (the Local Density Approximation combined with the Dynamical Mean-Field Theory) calculation with this parameters results in weakly correlated electronic structure that is in agreement with X-ray experimental spectra

Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx43 was increased in the TMZ-resistant low passage and cell lines. This correlated with the data in The Cancer Genome Atlas. Cx43 knockdown, reporter gene assays, chromatin immunoprecipitation assay, real-time PCR and western blots verified a role for Cx43 in TMZ resistance. This occurred by TMZ-resistant GBM cells being able to activate epidermal growth factor receptor (EGFR). In turn, EGFR activated the JNK-ERK1/2-AP-1 axis to induce Cx43. The increased Cx43 was functional as indicated by gap junctional intercellular communication among the resistant GBM cells. Cell therapy could be a potential method to deliver drugs, such as anti-EGF to tumor cells. Similar strategies could be used to reverse the expression of Cx43 to sensitize GBM cells to TMZ. The studies showed the potential for targeting EGF in immune therapy. These agents can be used in conjunction with stem cell therapy to treat GBM

H^+ -> W^+ l_i^- l_j^+$ decay in the two Higgs doublet model

We study the lepton flavor violating H^+ -> W^+ l_i^- l_j^+ and the lepton flavor conserving $H^+ -> W^+ l_i^- l_i^+ (l_i=\tau, l_j=\mu) decays in the general 2HDM, so called model III. We estimate the decay width \Gamma for LFV (LFC) at the order of the magnitude of (10^{-11}-10^{-5}) GeV ((10^{-9}-10^{-4}) GeV), for 200 GeV\leq m_{H^\pm}\leq 400 GeV, and the intermediate values of the coupling \bar{\xi}^{E}_{N,\tau \mu}\sim 5 GeV (\bar{\xi}^{E}_{N,\tau \tau}\sim 30 GeV). We observe that the experimental result of the process under consideration can give comprehensive information about the physics beyond the standard model and the existing free parameters.Comment: 8 pages, 7 Figure

Dynamics of spin correlations in the spin-1/2 isotropic XY chain in a transverse field

Dynamic xx spin pair correlation functions for the isotropic spin-1/2 XY chain are calculated numerically for long open chains in the presence of a transverse magnetic field at finite temperature. As an application we discuss the temperature dependence of the spin-spin relaxation time in PrCl_3.Comment: 2 pages, latex, 2 figures, abstract of the paper presented at Ampere Summer School ``Applications of Magnetic Resonance in Novel Materials'' Nafplion, Greece, 3-9 September, 2000, partially published in J. Phys. A: Math. Gen. 33, 3063 (2000

Dynamics of a thin shell in the Reissner-Nordstrom metric

We describe the dynamics of a thin spherically symmetric gravitating shell in the Reissner-Nordstrom metric of the electrically charged black hole. The energy-momentum tensor of electrically neutral shell is modelled by the perfect fluid with a polytropic equation of state. The motion of a shell is described fully analytically in the particular case of the dust equation of state. We construct the Carter-Penrose diagrams for the global geometry of the eternal black hole, which illustrate all possible types of solutions for moving shell. It is shown that for some specific range of initial parameters there are possible the stable oscillating motion of the shell transferring it consecutively in infinite series of internal universes. We demonstrate also that this oscillating type of motion is possible for an arbitrary polytropic equation of state on the shell.Comment: 17 pages, 7 figure