Detecting extreme mass ratio inspirals with LISA using time-frequency methods II: search characterization

The inspirals of stellar-mass compact objects into supermassive black holes constitute some of the most important sources for LISA. Detection of these sources using fully coherent matched filtering is computationally intractable, so alternative approaches are required. In a previous paper (Wen and Gair 2005, gr-qc/0502100), we outlined a detection method based on looking for excess power in a time-frequency spectrogram of the LISA data. The performance of the algorithm was assessed using a single `typical' trial waveform and approximations to the noise statistics. In this paper we present results of Monte Carlo simulations of the search noise statistics and examine its performance in detecting a wider range of trial waveforms. We show that typical extreme mass ratio inspirals (EMRIs) can be detected at distances of up to 1--3 Gpc, depending on the source parameters. We also discuss some remaining issues with the technique and possible ways in which the algorithm can be improved.Comment: 15 pages, 9 figures, to appear in proceedings of GWDAW 9, Annecy, France, December 200

Design of Copolymeric Materials

We devise a method for designing materials that will have some desired structural characteristics. We apply it to multiblock copolymers that have two different types of monomers, A and B. We show how to determine what sequence of A's and B's should be synthesised in order to give a particular structure and morphology. %For example in a melt of such %polymers, one may wish to engineer a body-centered %cubic structure. Using this method in conjunction with the theory of microphase separation developed by Leibler, we show it is possible to efficiently search for a desired morphology. The method is quite general and can be extended to design isolated heteropolymers, such as proteins, with desired structural characteristics. We show that by making certain approximations to the exact algorithm, a method recently proposed by Shakhnovich and Gutin is obtained. The problems with this method are discussed and we propose an improved approximate algorithm that is computationally efficient.Comment: 15 pages latex 2.09 and psfig, 1 postscript figure

Multidisciplinary approach to the management of children with female genital mutilation (FGM) or suspected FGM: service description and case series

OBJECTIVE: To describe the first dedicated clinic in the UK for children with suspected or confirmed female genital mutilation (FGM) including referral patterns, clinical findings and subsequent management. DESIGN AND SETTING: A prospective study of all children seen in a dedicated multidisciplinary FGM clinic for children over a 1-year period. POPULATION: Patients aged under 18 years referred for clinical assessment or for a second opinion on Digital Versatile Disc (DVD) images. METHODS AND MAIN OUTCOME MEASURES: Data were collected on reasons for referral, demography, genital examination findings including FGM type, and clinical recommendations. RESULTS: 38 children were referred of whom 18 (47%) had confirmed FGM; most frequently type 4 (61%). Social care and police referred 78% of cases. According to UK law FGM had been performed illegally in three cases. Anonymous information given to the police led to the referral of six children, none of whom had had FGM. CONCLUSIONS: Mandatory reporting and increased media attention may increase the numbers of referrals of children with suspected FGM. This patient group have complex needs and management in a dedicated multidisciplinary service is essential. Paediatricians and gynaecologists should have the skills to carry out the consultation and detect all types of FGM including type 4 which was the most common type seen in this series. This is the first dedicated FGM service for children in the UK and similar clinics in high-prevalence areas should be established

Learning about compact binary merger: the interplay between numerical relativity and gravitational-wave astronomy

Activities in data analysis and numerical simulation of gravitational waves have to date largely proceeded independently. In this work we study how waveforms obtained from numerical simulations could be effectively used within the data analysis effort to search for gravitational waves from black hole binaries. We propose measures to quantify the accuracy of numerical waveforms for the purpose of data analysis and study how sensitive the analysis is to errors in the waveforms. We estimate that ~100 templates (and ~10 simulations with different mass ratios) are needed to detect waves from non-spinning binary black holes with total masses in the range 100 Msun < M < 400 Msun using initial LIGO. Of course, many more simulation runs will be needed to confirm that the correct physics is captured in the numerical evolutions. From this perspective, we also discuss sources of systematic errors in numerical waveform extraction and provide order of magnitude estimates for the computational cost of simulations that could be used to estimate the cost of parameter space surveys. Finally, we discuss what information from near-future numerical simulations of compact binary systems would be most useful for enhancing the detectability of such events with contemporary gravitational wave detectors and emphasize the role of numerical simulations for the interpretation of eventual gravitational-wave observations.Comment: 19 pages, 12 figure

Pan-urologic cancer genomic subtypes that transcend tissue of origin

AbstractUrologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of multidimensional and comprehensive molecular characterization (including DNA methylation and copy number, and RNA and protein expression). Tissue dominant effects are first removed computationally in order to define these subtypes, which reveal common processes—reflecting in part tumor microenvironmental influences—driving cellular behavior across tumor lineages. Six of the subtypes feature a mixture of represented cancer types as defined by tissue or cell of origin. Differences in patient survival and in the manifestation of specific pathways—including hypoxia, metabolism, NRF2-ARE, Hippo, and immune checkpoint—can further distinguish the subtypes. Immune checkpoint markers and molecular signatures of macrophages and T cell infiltrates are relatively high within distinct subsets of each cancer type studied. The pan-urologic cancer genomic subtypes would facilitate information sharing involving therapeutic implications between tissue-oriented domains.</jats:p

An excess power statistic for detection of burst sources of gravitational radiation

We examine the properties of an excess power method to detect gravitational waves in interferometric detector data. This method is designed to detect short-duration (< 0.5 s) burst signals of unknown waveform, such as those from supernovae or black hole mergers. If only the bursts' duration and frequency band are known, the method is an optimal detection strategy in both Bayesian and frequentist senses. It consists of summing the data power over the known time interval and frequency band of the burst. If the detector noise is stationary and Gaussian, this sum is distributed as a chi-squared (non-central chi-squared) deviate in the absence (presence) of a signal. One can use these distributions to compute frequentist detection thresholds for the measured power. We derive the method from Bayesian analyses and show how to compute Bayesian thresholds. More generically, when only upper and/or lower bounds on the bursts duration and frequency band are known, one must search for excess power in all concordant durations and bands. Two search schemes are presented and their computational efficiencies are compared. We find that given reasonable constraints on the effective duration and bandwidth of signals, the excess power search can be performed on a single workstation. Furthermore, the method can be almost as efficient as matched filtering when a large template bank is required. Finally, we derive generalizations of the method to a network of several interferometers under the assumption of Gaussian noise.Comment: 22 pages, 6 figure

Stigma in Male Depression and Suicide: A Canadian Sex Comparison Study

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Stigma in men’s depression and suicide can restrict help-seeking, reduce treatment compliance and deter individuals from confiding in friends and family. In this article we report sex comparison findings from a national survey of English-speaking adult Canadians about stigmatized beliefs concerning male depression and suicide. Among respondents without direct experience of depression or suicide (n = 541) more than a third endorsed the view that men with depression are unpredictable. Overall, a greater proportion of males endorsed stigmatizing views about male depression compared to female respondents. A greater proportion of female respondents endorsed items indicating that men who suicide are disconnected, lost and lonely. Male and female respondents with direct personal experience of depression or suicide (n = 360) strongly endorsed stigmatizing attitudes toward themselves and a greater proportion of male respondents indicated that they would be embarrassed about seeking help for depression

Observational Limit on Gravitational Waves from Binary Neutron Stars in the Galaxy

Using optimal matched filtering, we search 25 hours of data from the LIGO 40-meter prototype laser interferometric gravitational-wave detector for gravitational-wave chirps emitted by coalescing binary systems within our Galaxy. This is the first test of this filtering technique on real interferometric data. An upper limit on the rate R of neutron star binary inspirals in our Galaxy is obtained: with 90% confidence, R< 0.5/hour. Similar experiments with LIGO interferometers will provide constraints on the population of tight binary neutron star systems in the Universe.Comment: RevTeX, minor revisions, exactly as published in PRL 83 (1999) p1498, 4 pages, 2 figures include

Entropy of Constant Curvature Black Holes in General Relativity

We consider the thermodynamic properties of the constant curvature black hole solution recently found by Banados. We show that it is possible to compute the entropy and the quasilocal thermodynamics of the spacetime using the Einstein-Hilbert action of General Relativity. The constant curvature black hole has some unusual properties which have not been seen in other black hole spacetimes. The entropy of the black hole is not associated with the event horizon; rather it is associated with the region between the event horizon and the observer. Further, surfaces of constant internal energy are not isotherms so the first law of thermodynamics exists only in an integral form. These properties arise from the unusual topology of the Euclidean black hole instanton.Comment: 4 pages LaTeX2e (RevTeX), 2 PostScript figures. Small corrections in the text and the reference

Finite size effects on thermal denaturation of globular proteins

Finite size effects on the cooperative thermal denaturation of proteins are considered. A dimensionless measure of cooperativity, Omega, scales as N^zeta, where N is the number of amino acids. Surprisingly, we find that zeta is universal with zeta = 1 + gamma, where the exponent gamma characterizes the divergence of the susceptibility for a self-avoiding walk. Our lattice model simulations and experimental data are consistent with the theory. Our finding rationalizes the marginal stability of proteins and substantiates the earlier predictions that the efficient folding of two-state proteins requires the folding transition temperature to be close to the collapse temperature.Comment: 3 figures. Physical Review Letters (in press