18 research outputs found
Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs
No full textPeriductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis
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3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry
Get PDFExtracellular matrix plays a central role in driving cancer development. Here the authors using an in vitro approach show that confining collagen architectures induce fast and persistent cell migration and the formation of multicellular network structures linked to vascular mimicry observed in tumours from patients
Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread
No full textÎĽMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure
No full textMatrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
No full textAnisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
No full textMicrofluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance
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