56 research outputs found
Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.
Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tReviewExperimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.Internationale Stichting Alzheimer Onderzoek (ISAO)Netherlands Organization for Scientific Research (NWO)Maastricht University Medical Centre 
From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
A study of geographical distance groups on length of visitors’ stay at local food festival destinations
Towards Urbanome the genome of the city to enhance the form and function of future cities
Tension receptors on the closer muscle apodeme in the walking legs of the blue crab,Callinectes sapidus
An Early Anticipation of Smart Growth? John Stuart Mill, Knowledge and the ‘East-West’ Distinction
Neck and waist circumference values according to sex, age, and body-mass index: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
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