Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000

The aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZQ). The solubility of PZQ in solid dispersions and physical mixtures was assessed in purified water and TC-199 buffer. The everted intestinal sac model was employed to assess, in vitro, intestinal absorption of PZQ. A significant enhancement in both in vitro solubility and intestinal absorption of PZQ was found in solid dispersions compared to pure PZQ and physical mixtures. This positive series of preliminary results showed that solid dispersion of PEG 6000 is a valuable strategy for increasing bioavailability of PZQ and could also prove useful for other poorly water-soluble drugs.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Conservation units in the core area of the Cerrado domain: an overview on the small nonvolant mammals (Rodentia and Didelphimorphia)

A review of small non-volant mammal species of the APA Gama e Cabeça de Veado was carried out, including new surveys in the "Estação Ecológica do Jardim Botânico" (EEJBB) and "Reserva Ecológica do Instituto Brasileiro de Geografia e Estatí­stica" (REIBGE). Thirty-one small mammal's species are registered for the APA Gama and Cabeça de Veado, including one exotic species. Didelphis albiventris, Hylaeamys megacephalus, and Oxymycterus delator were collected for the first time in EEJBB. The APA Gama-Cabeça de Veado has a central position in the Cerrado domain sharing six species with the Amazon domain, five with Atlantic Forest, and 13 with Caatinga. The APA Gama-Cabeça de Veado encompasses the home range of at least six non-volant small mammal species endemic of Cerrado domain, and it has an important role in the protection of these endemic species and species that occurs in those four South America morphoclimatic domains

Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000

The aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZQ). The solubility of PZQ in solid dispersions and physical mixtures was assessed in purified water and TC-199 buffer. The everted intestinal sac model was employed to assess, in vitro, intestinal absorption of PZQ. A significant enhancement in both in vitro solubility and intestinal absorption of PZQ was found in solid dispersions compared to pure PZQ and physical mixtures. This positive series of preliminary results showed that solid dispersion of PEG 6000 is a valuable strategy for increasing bioavailability of PZQ and could also prove useful for other poorly water-soluble drugs.Colegio de Farmacéuticos de la Provincia de Buenos Aire