25 research outputs found
Hall-effect evolution across a heavy-fermion quantum critical point
A quantum critical point (QCP) develops in a material at absolute zero when a
new form of order smoothly emerges in its ground state. QCPs are of great
current interest because of their singular ability to influence the finite
temperature properties of materials. Recently, heavy-fermion metals have played
a key role in the study of antiferromagnetic QCPs. To accommodate the heavy
electrons, the Fermi surface of the heavy-fermion paramagnet is larger than
that of an antiferromagnet. An important unsolved question concerns whether the
Fermi surface transformation at the QCP develops gradually, as expected if the
magnetism is of spin density wave (SDW) type, or suddenly as expected if the
heavy electrons are abruptly localized by magnetism. Here we report
measurements of the low-temperature Hall coefficient () - a measure of the
Fermi surface volume - in the heavy-fermion metal YbRh2Si2 upon field-tuning it
from an antiferromagnetic to a paramagnetic state. undergoes an
increasingly rapid change near the QCP as the temperature is lowered,
extrapolating to a sudden jump in the zero temperature limit. We interpret
these results in terms of a collapse of the large Fermi surface and of the
heavy-fermion state itself precisely at the QCP.Comment: 20 pages, 3 figures; to appear in Natur
Quantum Criticality in Heavy Fermion Metals
Quantum criticality describes the collective fluctuations of matter
undergoing a second-order phase transition at zero temperature. Heavy fermion
metals have in recent years emerged as prototypical systems to study quantum
critical points. There have been considerable efforts, both experimental and
theoretical, which use these magnetic systems to address problems that are
central to the broad understanding of strongly correlated quantum matter. Here,
we summarize some of the basic issues, including i) the extent to which the
quantum criticality in heavy fermion metals goes beyond the standard theory of
order-parameter fluctuations, ii) the nature of the Kondo effect in the quantum
critical regime, iii) the non-Fermi liquid phenomena that accompany quantum
criticality, and iv) the interplay between quantum criticality and
unconventional superconductivity.Comment: (v2) 39 pages, 8 figures; shortened per the editorial mandate; to
appear in Nature Physics. (v1) 43 pages, 8 figures; Non-technical review
article, intended for general readers; the discussion part contains more
specialized topic
Developmental and pathological lymphangiogenesis: from models to human disease.
The lymphatic vascular system, the body's second vascular system present in vertebrates, has emerged in recent years as a crucial player in normal and pathological processes. It participates in the maintenance of normal tissue fluid balance, the immune functions of cellular and antigen trafficking and absorption of fatty acids and lipid-soluble vitamins in the gut. Recent scientific discoveries have highlighted the role of lymphatic system in a number of pathologic conditions, including lymphedema, inflammatory diseases, and tumor metastasis. Development of genetically modified animal models, identification of lymphatic endothelial specific markers and regulators coupled with technological advances such as high-resolution imaging and genome-wide approaches have been instrumental in understanding the major steps controlling growth and remodeling of lymphatic vessels. This review highlights the recent insights and developments in the field of lymphatic vascular biology
Interdisciplinary multimodal assessment and risk-tailored pathways for patients with back pain
Oncologic Effectiveness of Regular Follow-up to Detect Recurrence After Curative Resection of Gastric Cancer
Enzymatic reactions in confined environments
Within each biological cell, surface- and volume-confined enzymes control a highly complex network of chemical reactions. These reactions are efficient, timely, and spatially defined. Efforts to transfer such appealing features to in vitro systems have led to several successful examples of chemical reactions catalysed by isolated and immobilized enzymes. In most cases, these enzymes are either bound or adsorbed to an insoluble support, physically trapped in a macromolecular network, or encapsulated within compartments. Advanced applications of enzymatic cascade reactions with immobilized enzymes include enzymatic fuel cells and enzymatic nanoreactors, both for in vitro and possible in vivo applications. In this Review, we discuss some of the general principles of enzymatic reactions confined on surfaces, at interfaces, and inside small volumes. We also highlight the similarities and differences between the in vivo and in vitro cases and attempt to critically evaluate some of the necessary future steps to improve our fundamental understanding of these systems