Palladium-mediated dealkylation of N-propargyl-floxuridine as a bioorthogonal oxygen-independent prodrug strategy

Herein we report the development and biological screening of a bioorthogonal palladium-labile prodrug of the nucleoside analogue floxuridine, a potent antineoplastic drug used in the clinic to treat advanced cancers. N-propargylation of the N3 position of its uracil ring resulted in a vast reduction of its biological activity (~6,250-fold). Cytotoxic properties were bioorthogonally rescued in cancer cell culture by heterogeneous palladium chemistry both in normoxia and hypoxia. Within the same environment, the reported chemo-reversible prodrug exhibited up to 1,450-fold difference of cytotoxicity whether it was in the absence or presence of the extracellular palladium source, underlining the precise modulation of bioactivity enabled by this bioorthogonally-activated prodrug strategy

Big issues for small feet : developmental, biomechanical and clinical narratives on children's footwear

The effects of footwear on the development of children's feet has been debated for many years and recent work from the developmental and biomechanical literature has challenged long-held views about footwear and the impact on foot development. This narrative review draws upon existing studies from developmental, biomechanical and clinical literature to explore the effects of footwear on the development of the foot. The emerging findings from this support the need for progress in [children's] footwear science and advance understanding of the interaction between the foot and shoe. Ensuring clear and credible messages inform practice requires a progressive evidence base but this remains big issue in children's footwear research

Human Rights Attitude and Civic Engagement Behavior Among University Students

Although civic engagement and human rights are critical values in social work education, few empirical studies have explored the association between civic engagement and human rights exposure and attitudes. This study aims to examine the relationship between the exposure to human rights information, human rights attitudes, normative beliefs, and civic engagement behaviors among university students. A total of 214 students at a public university in the Midwest of the United States responded to the study survey. Findings indicate that students with more exposure to human rights issues showed more civic engagement. This relationship between human rights exposure and civic engagement was mediated by students’ attitudes toward human rights, but not moderated by normative beliefs. In addition, students majoring in social work revealed higher civic engagement and more positive attitudes toward human rights issues than those in other disciplines