51 research outputs found
Response to Treatment and Disease Progression Linked to CD4+ T Cell Surface CC Chemokine Receptor 5 Density in Human Immunodeficiency Virus Type 1 Vertical Infection
Get PDFThe factors governing interindividual variability in disease progression among children vertically infected with human immunodeficiency virus type 1 (HIV-1) remain unclear. Because it has recently been shown in infected adults that the density of CC chemokine receptor 5 (CCR5) molecules at the surface of nonactivated (human leukocyte antigen [HLA]-DR-) CD4+ T cells correlates with disease progression, the same correlation was sought in children. HLA-DR-CD4+ T cell surface CCR5 density was constant over time and correlated with the bioclinical stage and with the CD4 cell slope observed before antiretroviral treatment. In addition, CCR5 density was negatively correlated with the intensity of the decrease in viremia during antiretroviral therapy and was positively correlated with CD4 cell slope since birth. These results are compatible with the hypothesis that CCR5 density is a key factor governing disease progression in pediatric HIV-1 infection and, thereby, an indicator of prognosis. Moreover, they suggest that therapies aimed at reducing CCR5 accessibility should slow down HIV disease evolution in childre
La larvothérapie dans le traitement du pied diabétique
No full textPARIS-BIUP (751062107) / SudocSudocFranceF
Le syndrome de Cushing et ses traitements, hépatotoxicité d'un anticortisolique de synthèse (l'OP' DDD, étude de 10 cas)
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De l'érythropoïetine endogène à l'érythropoïetine humaine recombinante
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Influence des effets secondaires et lipodystrophies dans l'adhésion des patients VIH+ aux traitements antirétroviraux. Le rôle du pharmacien au sein de l'équipe soignante dans le maintien de l'observance
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Probiotiques et maladies inflammatoires chroniques de l'intestin
No full textPARIS-BIUP (751062107) / SudocSudocFranceF
Aspect pratique des traitements de la dysthyroïdie
No full textPARIS-BIUP (751062107) / SudocSudocFranceF
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