Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective microbiota-mediated mechanisms was retained. Beneficial health effects must be documented for a substance to be considered a prebiotic. The consensus definition applies also to prebiotics for use by animals, in which microbiota-focused strategies to maintain health and prevent disease is as relevant as for humans. Ultimately, the goal of this Consensus Statement is to engender appropriate use of the term ‘prebiotic’ by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category. To this end, we have reviewed several aspects of prebiotic science including its development, health benefits and legislation

Modeling of interferences during thread milling operation

Thread milling is becoming more and more employed as a technique for producing thread, due to its advantages for industrial manufacturing sectors, such as the aeronautics, aerospace, and energy industries. The thread milling operation is atypical and several aspects have to be taken into account to perform it in good conditions. As for milling or grinding worms, grooves, thread or others sculptured surfaces, in thread milling, there exists a geometrical interference between the tool and the nominal surface which would be obtained. Thread mills have quite complex geometry and their profile has an effect on the machined thread. The present study details geometrical aspects of the thread milling process. This article deals with the link between thread mill geometry and nominal thread profile. An approach is proposed to analyze the thread profile generated by the thread mill envelope. It is deduced that thread milling produces interferences, i.e. the machined thread profile is affected by an overcut. A method is proposed to correct this geometrical error in order to produce accurate thread

Geometrical analysis of thread milling – Part 2:Calculation of uncut chip thickness

Thread milling offers interesting possibilities for machining internal or external threads. This machining technique uses a mill with a triangular profile for metric threads and a helical interpolation strategy. Thus, the uncut chip thickness can not be easily evaluated from a simplified approach. The present study deals with a model for calculating uncut chip thickness during internal thread milling. This step is needed to understand and model the cutting forces. The model developed uses the geometrical definitions of the mill, and takes into account the milling mode and the cutting conditions. The link with the interferences between the tool and the thread is also established and corroborates a previous study. A full analyticalformulation of the problem is proposed, and results from different milling settings are presented