20 research outputs found
Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney Induction
- Author
- A Ali
- A Majumdar
- A Schedl
- A Schuchardt
- Abdallah Souabni
- AM Bertoli-Avella
- AM Hernandez
- BJ Gavin
- Calli Merkel
- CI Rodriguez
- CN Ting
- D Grote
- D Henrique
- David Grote
- EH Jho
- F Costantini
- F Kuwayama
- Frank Costantini
- G Cacalano
- G Minowada
- GP Holmes
- GR Dressler
- H Enomoto
- H Van Esch
- H Van Esch
- I Ichikawa
- J Qiao
- J Yu
- JG Pichel
- KC Lim
- KM George
- L Chi
- L Fedele
- L Meijer
- L Michael
- L Mologni
- L Saxen
- M Bouchard
- M Bouchard
- M Khandekar
- M Pohl
- M Takahashi
- M Yoshida
- MA Basson
- MA Skinner
- Maxime Bouchard
- MD Tallquist
- ML Waterman
- MP Sanchez
- MW Moore
- N Fujimura
- O Michos
- P Soriano
- PD Vize
- PH Crossley
- PL Pfeffer
- PP Pandolfi
- R Shakya
- RK Patient
- RV Pearse 2nd
- S Bellusci
- S Fisher
- S Srinivas
- S Weber
- Sami Kamel Boualia
- SH Orkin
- SL Hasegawa
- T Kume
- T Nakano
- TD Marose
- Thomas Carroll
- U Grieshammer
- V Pachnis
- Veronica van Heyningen
- VP Eswarakumar
- W Lu
- Xuan Chi
- Y Miyazaki
- Z Steinberg
- Publication venue
- Public Library of Science
- Publication date
- 01/12/2008
- Field of study
Metanephric kidney induction critically depends on mesenchymal–epithelial interactions in the caudal region of the nephric (or Wolffian) duct. Central to this process, GDNF secreted from the metanephric mesenchyme induces ureter budding by activating the Ret receptor expressed in the nephric duct epithelium. A failure to regulate this pathway is believed to be responsible for a large proportion of the developmental anomalies affecting the urogenital system. Here, we show that the nephric duct-specific inactivation of the transcription factor gene Gata3 leads to massive ectopic ureter budding. This results in a spectrum of urogenital malformations including kidney adysplasia, duplex systems, and hydroureter, as well as vas deferens hyperplasia and uterine agenesis. The variability of developmental defects is reminiscent of the congenital anomalies of the kidney and urinary tract (CAKUT) observed in human. We show that Gata3 inactivation causes premature nephric duct cell differentiation and loss of Ret receptor gene expression. These changes ultimately affect nephric duct epithelium homeostasis, leading to ectopic budding of interspersed cells still expressing the Ret receptor. Importantly, the formation of these ectopic buds requires both GDNF/Ret and Fgf signaling activities. We further identify Gata3 as a central mediator of β-catenin function in the nephric duct and demonstrate that the β-catenin/Gata3 pathway prevents premature cell differentiation independently of its role in regulating Ret expression. Together, these results establish a genetic cascade in which Gata3 acts downstream of β-catenin, but upstream of Ret, to prevent ectopic ureter budding and premature cell differentiation in the nephric duct
FRAX tool in type 2 diabetic subjects: the use of HbA1c in estimating fracture risk
- Author
- A Bertoli
- ADA
- Aldo Bertoli
- Alessia Valentini
- AV Schwartz
- AV Schwartz
- AV Schwartz
- AV Schwartz
- BN Conway
- C Conte
- C Hamann
- CI Li
- Daniele Romanello
- G Hendickx
- GI Schacter
- II Liefde de
- JA Kanis
- JA Kanis
- JS Skyler
- L Oei
- Livia De Meo
- LJ Melton
- LM Giangregorio
- M Janghorbani
- M Monami
- M Yamamoto
- M Yamamoto
- Maria Assunta Cianfarani
- Massimo Federici
- MP Gilbert
- MR Rubin
- MS Kirkman
- N Ahmed
- N Napoli
- N Napoli
- P Sambrook
- P Vestergaard
- Pasquale Morabito
- RQ Ivers
- S Viguet-Carrin
- SR Cummings
- SR Majumdar
- SS Johnston
- SY Goh
- TD Rachner
- Umberto Tarantino
- V Carnevale
- W Leslie
- WD Leslie
- WD Leslie
- Y Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Trait Associations across Evolutionary Time within a Drosophila Phylogeny: Correlated Selection or Genetic Constraint?
- Author
- A Addo-Bediako
- A Duputie
- AA Hoffmann
- AA Hoffmann
- AA Hoffmann
- AA Hoffmann
- AA Hoffmann
- AC James
- AF Agrawal
- AG Gibbs
- AG Gibbs
- AR Anderson
- AR Anderson
- Ary A. Hoffmann
- BJ Sinclair
- CDL Orme
- CI Bertoli
- CL Lyons
- D Karan
- E Hine
- E Paradis
- HA MacMillan
- I Karl
- J van Herrewege
- JG Kingsolver
- JH Brown
- JL Gittleman
- JM Scriber
- Johannes Overgaard
- JR Etterson
- K van der Linde
- LB Hutley
- LM Matzkin
- M Greve
- M Pagel
- MT Kimura
- MW Blows
- OA Bubliy
- R Parkash
- RB Huey
- RJ Hijmans
- SL Chown
- SP Blomberg
- Suzannah Rutherford
- SW Kembel
- TF Hansen
- Torsten Nygaard Kristensen
- V Kellermann
- V Kellermann
- Vanessa Kellermann
- Volker Loeschcke
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Gender differences in the long-term effects of a nutritional intervention program promoting the Mediterranean diet: changes in dietary intakes, eating behaviors, anthropometric and metabolic variables
- Author
- A Bedard
- A Sanchez-Villegas
- AJ Stunkard
- AN Mudryj
- Anne-Marie Hudon
- AP Hearty
- ATP Ncep III
- B Fjeldsoe
- BM Landgren
- C Beunckens
- Canadian Institutes of Health Research-Institute of Gender and Health
- Catherine Bégin
- CI Voils
- CSA Arganini
- D Garriguet
- D Riebe
- D Trouilloud
- EA Hu
- EM Welsh
- F Sofi
- G Grosso
- H Schroder
- I Zazpe
- J Goulet
- J Goulet
- J Goulet
- J Goulet
- J Goulet
- J Wardle
- J Westenhoefer
- Louise Corneau
- LW Mroz
- M Bastien
- M Garaulet
- M Lucas
- M Yannakoulia
- Marie-Michelle Royer
- ME Addis
- MJ Bond
- NP Hays
- P Kendall
- R Estruch
- R Hoffman
- RM Ryan
- S Bertoli
- S Desroches
- S Lemieux
- Simone Lemieux
- SK Kumanyika
- SM Downs
- SM Grundy
- SR Smith
- Sylvie Dodin
- T Haidinger
- T Lohman
- TA Miller
- UF Bailer
- V Provencher
- Vicky Leblanc
- WJ Bemelmans
- WT Friedewald
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evidence of rapid spread and establishment of Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) in semi-arid Botswana
- Author
- A Biondi
- A Cocco
- A Urbaneja
- AA Hoffmann
- AC Kruger
- AF Dixon
- AG Farji-Brener
- AL Kelley
- AL Kelley
- C Ferracini
- C Nyamukondiwa
- C Nyamukondiwa
- C Nyamukondiwa
- CA Deutsch
- CI Bertoli
- D Pfeiffer
- D Renault
- D Son
- DM Richardson
- F Chidawanyika
- F Gerhardt
- H Machekano
- H Machekano
- HEZ Tonnang
- I Toševski
- JC Martins
- JF Germain
- JR Carey
- JS Bale
- JS Terblanche
- K Abbes
- L Biber-Freudenberger
- LA Santos dos
- LB Perkins
- M Chidege
- M Chidege
- M Szucs
- ME Dillon
- N Desneux
- N Desneux
- N Gotcha
- N Khadioli
- NR Andrew
- O Karadjova
- R Mutamiswa
- R Mutamiswa
- RP Duncan
- S Kumschick
- SA Lux
- SL Chown
- SL Chown
- SL Chown
- SV Olyarnik
- T Bawin
- T Brévault
- T Manenti
- TA Crowl
- TJ Henneberry
- TM Blackburn
- V Jarošík
- V Tumuhaise
- Visser D Uys VM, Nieuwenhuis RJ, Pieterse W. First records of the tomato leaf miner Tuta absoluta (Meyrick
- W Nentwig
- XQ Chang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multiple paths to cold tolerance: the role of environmental cues, morphological traits and the circadian clock gene vrille
- Author
- A Addo-Bediako
- A Ayrinhac
- A Maysov
- A Tarasov
- AA Hoffmann
- AA Hoffmann
- AF Barber
- AR Anderson
- AR Gerken
- B Helmuth
- BJ Sinclair
- C Condon
- C Espinoza
- C Helfrich-Förster
- C Nyamukondiwa
- CA Schneider
- CI Bertoli
- CJ Klok
- D Doucet
- D Hopkins
- D Zeuss
- DA Hahn
- DJ Parker
- DJ Parker
- DJ Parker
- DL Denlinger
- E Bertolini
- E Zuther
- FM Norry
- FM Vigoder
- GN Somero
- H Bastide
- H Colinet
- H Colinet
- H Kauranen
- H Kauranen
- H Kauranen
- H Li
- H Li
- HA MacMillan
- HA Macmillan
- HA MacMillan
- HA MacMillan
- HA MacMillan
- HO Pörtner
- I Scharf
- IC Kutch
- J Aspi
- J Aspi
- J Overgaard
- J Overgaard
- J Overgaard
- J Overgaard
- J Overgaard
- JA Williams
- JH Massey
- JL Andersen
- JL Andersen
- JM Sunday
- JR True
- JS Davis
- JS Terblanche
- JT Patterson
- KE Gil
- KH Kozak
- KL Gunawardhana
- L Heidrich
- L Vesala
- L Vesala
- L Vesala
- L Vesala
- LE Castañeda
- LE Des Marteaux
- LH Throckmorton
- M Flourakis
- M Klockmann
- M Telonis-Scott
- ME Brooks
- MJ Angilletta
- MJ Garcia
- MS Clark
- MT Kimura
- MV Vinarski
- N Poikela
- NM Teets
- NM Teets
- P Gibert
- P Gibert
- P Menegazzi
- PE Hardin
- PJ Wittkopp
- R Hallas
- RH Hegna
- S Chen
- S Clusella-Trullas
- S Clusella-Trullas
- S Dray
- S Lê
- S Noh
- S Rajpurohit
- S Ramniwas
- SE Fick
- SJ Franks
- SL Chown
- SL Chown
- T Enriquez
- T Flatt
- TS Salminen
- V Kellermann
- V Kellermann
- VI Tyukmaeva
- WU Blanckenhorn
- WU Blanckenhorn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses
- Author
- A Cozzi
- A Cozzi
- A Cozzi
- A Cozzi
- A Dignass
- A Jacobs
- A Ndayisaba
- A Obolensky
- A Raghunath
- AA Mangaonkar
- AH Ajzashokouhi
- AR Vasconcelos
- AV Makeyev
- B Chiou
- B Erdemli
- BB Muhoberac
- BE Bulvik
- BH Foy
- BR Stockwell
- BW Huang
- C Bachmeyer
- C Badu-Boateng
- C Ferreira
- C Ferreira
- C Nakagawa
- C Tello
- D Darshan
- D Finazzi
- D Nabhan
- D Tang
- DJR Lane
- E Cocco
- E Ferro
- E van Schaftingen
- EA Balashova
- EC Theil
- EL MacKenzie
- F Bou-Abdallah
- F Bou-Abdallah
- F Bou-Abdallah
- F Bou-Abdallah
- F Maccarinelli
- F Maccarinelli
- F Rezk Farhan
- G Balla
- G Gao
- G Vigani
- G Zhao
- H Jiang
- H Kawabata
- H Lv
- H Mochizuki
- H Wang
- HC Hatcher
- I De Domenico
- I De Domenico
- I Diouf
- J Balla
- J Chon
- J Daru
- J Daru
- J Drysdale
- J Giemza-Stokłosa
- J He
- J Hwang
- J Kato
- J Liu
- J Liu
- J Mieszkowski
- J Rouillon
- JC Cutrin
- JD Mancias
- JD Mancias
- JL Johnson
- JL Liu
- JO Cullis
- JR McNally
- JV Llorens
- K Fan
- K Iwasaki
- K Iwasaki
- K Thompson
- K Troha
- K Valkova
- KB Zumbrennen
- KJ Hintze
- L Chen
- L Cremonesi
- L Galluzzi
- L Gao
- L Kępa
- LH You
- M Chevion
- M Conrad
- M Gao
- M Quiles Del Rey
- M Tang
- M Volkmann
- M Wagstaff
- MA Carrondo
- MC Asensio-Lopez
- MC Asensio-López
- MC Pulos-Holmes
- MD Cappellini
- MD Cappellini
- MN Garcia-Casal
- MP Soares
- MS Field
- N Kajarabille
- N Santana-Codina
- O Nugzar
- P Arosio
- P Arosio
- P Santambrogio
- P Santambrogio
- P Santambrogio
- PC Parkin
- PK Koochana
- PM Harrison
- Q Luo
- Q Wu
- R Chang
- R Chirillo
- R Gozzelino
- R Lill
- R Putburee
- R Tehranchi
- R Vidal
- RM Mattila
- S Ayton
- S Bertoli
- S Bittermann
- S Ducamp
- S Levi
- S Levi
- S Levi
- S Levi
- S Levi
- S Levi
- S Lin
- S Ramos
- S Sui
- S Toyokuni
- S Weis
- T Kuwata
- T Tosha
- T Xu
- TB Bartnikas
- TM Bahr
- V Laufberger
- V Mattiello
- W Hou
- W Jin
- W Wu
- WE Dowdle
- X Meng
- Y Zhang
- YP Singh
- YQ Wang
- YZ Ci
- Z Liu
- Z Qin
- ZH Shi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandra Coelho
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Alif Adlan Thabit
- Alison M. Meynert
- Alistair Nichol
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Attanyake
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amélie Valran
- Ana Freitas Ribeiro
- Ana L Rios
- Ana Martins
- Ana Silva Filipe
- Anant Kataria
- Anca Streinu-Cercel
- Andrea Angheben
- Andrea Rossanese
- Andrew Dagens
- Andrew Udy
- Andrey Svistunov
- André Cabié
- André Dias
- Andy Law
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonio Lalueza
- António Mesquita
- Arabella Fahy
- Ardiyan Apriyana
- Arfan Ikram
- Aria Kekalih
- Arianne Joy Corpuz
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsene Kpangon
- Ary Serpa Neto
- Asgar Rishu
- Ashraf Sheharyar
- Asma Moin
- Astarini Hidayah
- Attaur Rehman
- Audrey Barrelet
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Azlan Mat Soom
- B. P Edouard Soum
- Barbara Wanjiru Citarella
- Basri Mat Nor
- Beatrice Alex
- Benedict Sim Heng
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Thill
- Benoit Visseaux
- Benoît Roze
- Bernard Cholley
- Bernardo Ferreira
- Bertrand Dussol
- Bharath Kumar Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Blandine Rammaert
- Bouchra Loufti
- Brenda Reeve
- Brigitte Elharrar
- Bronner P Gonçalves
- Bronner P. Gonçalves
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Calum Semple
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlo Giaquinto
- Carlos Alexandre Brito
- Carlos Lumbreras Bermejo
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Catarina Espírito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Cecile Azoulay
- Cecile Yelnik
- Cedric Laouenan
- Ceila Sant'Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Simona Cardellino
- Chloe Donohue
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Claire Andrejak
- Claire Lévy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D. Russell
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Clotilde Allavena
- Clément Le Bihan
- Colin McArthur
- Coline Jaud-Fischer
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cédric Joseph
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Dafsah Juzar
- Damien Bouhour
- Daniel Glikman
- Daniel Haber
- Daniel Marino
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- David L. Robertson
- David Maslove
- David Richardson
- David S.Y. Ong
- David Stuart
- David Thomson
- David Zucman
- Debby Bogaert
- Deepashankari Suppiah
- Dehbia Benkerrou
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Dewi Guellec
- Diana Adrião
- Diana Hernández
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Fernando Rincon
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dyah Kanya Wati
- Dzawani Muhamad
- Eder Caceres
- Edmund Manning
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elise Artaud-Macari
- Ellen Shadowitz
- Elodie Curlier
- Elsa Nyamankolly
- Ema Leal
- Eman Al Qasim
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'ortenzio
- Eric Delaveuve
- Eric Oziol
- Eric Senneville
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L'her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewa Talarek
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fakhir Haidri
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernando Augusto Bozza
- Fernando Maltez
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
- François Goehringer
- François Lellouche
- François Martin Carrier
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Félix Djossou
- Gabriel Macheda
- Gail Carson
- Gamage Dona Priyadarshani
- Gan Ee Xian
- Ganesh Kumar
- Gary Leeming
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Gilles Peytavin
- Giri Shan Rajahram
- Giulia Bertoli
- Graham S. Cooke
- Grazielle Viana Ramos
- Gry Kloumann Bekken
- Grégory Corvaisier
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
- Gwenaël Le Moal
- Gwenhaël Colin
- Ha Sha Lene
- Hajnal-Gabriela Illes
- Hanan Fateena
- Hanna Renk
- Hannah Habraken
- Hans Martin Bosse
- Harald Vonkeman
- Hashmi Madiha
- Hayley Hardwick
- Heidi Dalton
- Heidi Gruner
- Heidi Jean Dalton
- Heng Gee Lee
- Hervé Le Nagard
- Hiba Zayyad
- Hikombo Hitoto
- Himasha Muvindi
- Himed Musaab
- Hiu Jian Chua
- Hodane Yonis
- Hon Shen Png
- Hongru Ren
- Hubert Tessier-Grenier
- Huda Alfoudri
- Hugo Inácio
- Hugo Mouquet Ben Morton
- Hugues Aumaître
- Hugues Cordel
- Husna Begum
- Hwa Jin Cho
- Hélène Espérou
- Hélène Salvator
- Ikram Houas
- Ilka Engelmann
- Ilonka van Veen
- Ingrid G Bustos
- Irfan Khan
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- Isabelle Pironneau
- Ithan D. Peltan
- Ivy Cerelia Valerie
- J. Kenneth Baillie
- Jacky Y. Suen
- Jade Ghosn
- Jaganathan Selvanayagam
- Jaime Cruz Rojo
- Jake Dunning
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jananee Thirumanickam
- Janet Harrison
- Janet T. Scott
- Jaques Sztajnbok
- Jarne Van Hattem
- Jason Bouziotis
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean-Benoît Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-Sébastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jee Yan Ong
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- Neerusha Kaisbain
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- Nicholas Yee Hing
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- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Peter de Vries
- Peter Horby
- Peter Kiiza
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- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Philippe Jouvet
- Philippine Eloy
- Phoebe Ampaw
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- Piero L. Olliaro
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- Pratap Karpayah
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- Quratul Ain Khan
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- Raphael Favory
- Raphaël Borie
- Raquel Pinto
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- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Renata Barbalho
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rob Klont
- Robert A Fowler
- Robert A. Fowler
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- Robin Kobbe
- Rodrigo Díaz
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- Romain Decours
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- Romans Matulevics
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano Garcês
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saijad Orakzai
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
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- Sandrine Couffin-Cadiergues
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- Sara Clohisey
- Sara Machado
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- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Sebastien Preau
- Segolène Greffe
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Sia Loong Tonnii
- Sim Choon Ean
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Siri Goepel
- Siti Nurul Ridzuan
- Siti Rohani Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sobia Masood
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stella Rousset
- Stephanie Roberts
- Stephanie Yerkovich
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- Séverine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- Véronique Lemee
- Víctor Quirós González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adriano Enrico
- Adrião Diana
- Ageel Saleh Al
- Ahmed Shakeel
- Aiello Marina
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Adam
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Anwar Kazi Rubayet
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asaki Motohiro
- Asensio Angel
- Ashley Elizabeth A.
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atique Anika
- Attanyake AM Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Berge Marcel van den
- Bergeaud Delphine
- Bergin Hazel
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Betz Adam
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Bihan Clément Le
- Bisoffi Zeno
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Bonelli Patrizia
- Bonfasius Aurelius
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Bounphiengsy Thipsavanh
- Bountthasavong Latsaniphone
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Bris Cyril Le
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Buchtele Nina
- Bugaeva Polina
- Buisson Marielle
- Buonsenso Danilo
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Caminiti Caterina
- Camões João
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlacci Francesca
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Carvalho Leonor
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Cárcel Sheila
- Ceccato Adrian
- Cely Lina Morales
- Cerkovnik Shelby
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chaleunphon Bounthavy
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chatterjee Allegra
- Chau Nguyen Van Vinh
- Chen Anjellica
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chetta Alfredo Antonio
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chommanam Danoy
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chow Yock Ping
- Christy Nathaniel
- Chua Hiu Jian
- Chua Jonathan
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clifton Lei
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Cristella Cosimo
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Curto Elena Gallego
- Custodio Paula
- D'Aragon Frédérick
- D'Orleans Charles Crepy
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Piero Maria
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- De Rose Cristina
- de Silva Thushan
- de Velde Stijn Van
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Delfos Nathalie M.
- Deligiannis Ionna
- Dell'Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
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- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M
- Dong Andy
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
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- Greene Courtney
- Greenhalf William
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- Hamers Raph L.
- Hamidfar Rebecca
- Hammond Naomi
- Hammond Terese
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- Harrison Ewen M.
- Harrison Janet
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- Hough Catherine L.
- Houltham Stuart
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- Keshav Sharma
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- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kherajani Krish
- Kho Michelle E
- Khoo Denisa
- Khoo Ryan
- Khoo Saye
- Kiat Khor How
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- Kim Jae Burm
- Kimmoun Antoine
- Kindgen-Milles Detlef
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- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R
- Kobbe Robin
- Kodippily Chamira
- Komatsu Mamoru
- Korten ISARIC Collaborator
- Kosgei Caroline
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- Lacoste Marie
- Laffey John G.
- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
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- Le Minh
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- Lee Todd C.
- Lee Yi Lin
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
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- Lemee Véronique
- Lemeur Anthony
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- Lene Ha Sha
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- Lesens Olivier
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- Levy Yves
- Levy-Marchal Claire
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- Liang Janet
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- Lolong Navy
- Loon Leong Chee
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- Lopez-Colon Dalia
- Lopez-Revilla Jose W.
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
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- Low Lee Lee
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- Loy Jia Shyi
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- Luna Carlos M.
- Lungu Olguta
- Luong Liem
- Luque Nestor
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- Mahieu Rafael
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- Maia Ana Raquel
- Maier Lars S.
- Maillet Mylène
- Maitre Thomas
- Majori Maria
- Malaque Ceila Maria Sant‘Ana
- Malfertheiner Maximilian
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- Manda Victoria
- Mandei Jose M.
- Mandelbrot Laurent
- Manetta Frank
- Mankikian Julie
- Manning Edmund
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- Maréchal Marion Le
- Marino Daniel
- Marino Flávio
- Markowicz Samuel
- Marques Ana
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- Marsh Brian
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- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martinez F. Eduardo
- Martinot Martin
- Martins Ana
- Martins João
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- Martín-Quiros Alejandro
- Martucci Gennaro
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- Marwali Eva Miranda
- Marzukie Marsilla
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- Mathieu Daniel
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- Matulevics Romans
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- Mayxay Mayfong
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- McArthur Colin
- McCanny Peter
- McCarthy Aine
- McCarthy Anne
- McCloskey Colin
- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E.
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McEvoy Natalie
- McGeer Allison
- McKay Chris
- McKeown Johnny
- McLean Kenneth A.
- McNally Paul
- McNicholas Bairbre
- McPartlan Elaine
- Meaney Edel
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- Mechlin Maggie
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- Mele Ferruccio
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- Mendes Joao Joao
- Menkiti Ogechukwu
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- Mentré France
- Mentzer Alexander J.
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
- Mergeay-Fabre Mayka
- Mergler Blake
- Merson Laura
- Merson Laura
- Meschi Tiziana
- Mesinovic Munib
- Mesquita António
- Mestre Soizic Le
- Meta Roberta
- Metwally Osama
- Meybeck Agnès
- Meyer Dan
- Meynert Alison M.
- Meysonnier Vanina
- Meziane Amina
- Mezidi Mehdi
- Michelanglei Céline
- Michelet Isabelle
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- Mohamed Nik Nur Eliza
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- Moin Asma
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- Molloy Brenda
- Mone Mary
- Monteiro Agostinho
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- Moore Shona C.
- Morlaes Louis Gerbaud
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- Morton Ben
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- Müller Fredrik
- Müller Karl Erik
- Myrodia Dimitra Melia
- Nagard Hervé Le
- Nagpal Dave
- Nagrebetsky Alex
- Narasimhan Mangala
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- Neant Nadège
- Neb Holger
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- Neumann Emily
- Ng Pauline Yeung
- Nghi Anthony
- Nguyen Duc
- Nichol Alistair D
- Nitayavardhana Prompak
- Nonas Stephanie
- Noordin Nurul Amani Mohd
- Nor Basri Mat
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- Norman Lisa
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- Nowinski Adam
- Nseir Saad
- null null
- null null
- Nunez Jose I
- Nuñez Maria Angelica Rivera
- Nurnaningsih Nurnaningsih
- Nusantara Dwi Utomo
- Nyamankolly Elsa
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- Oliveira João
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- Olliaro Piero
- Olliaro Piero L.
- Ong David S. Y.
- Ong Jee Yan
- Oña Edwin Fernando Paredes
- Oosthuyzen Wilna
- Opavsky Anne
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- Patrier Juliette
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- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William A.
- Payen Jean-François
- Peake Sandra L
- Peariasamy Kalaiarasu
- Peariasamy Kalaiarasu M.
- Peek Giles J.
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Pelosi Paolo
- Peltan Ithan D.
- Pereira Rui
- Perez Daniel
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- Post Andra-Maris
- Postma Douwe F.
- Povoa Pedro
- Powis Jeff
- Póvoas Diana
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- Praphasiri Viladeth
- Preau Sébastien
- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
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- Purcell Gregory
- Qasim Eman Al
- Quesada Luisa
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- Rainieri Fernando
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- Rajahram Giri Shan
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- Ramalho José
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- Real Andre
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- Reeve Brenda
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- Reid Liadain
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- Ricchiuto Antonia
- Richardson David
- Richardson Denise
- Richier Laurent
- Ridzuan Siti Nurul Atikah Ahmad
- Riera Jordi
- Rincon Diego Fernando Bautista
- Rios Ana L
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Robba Chiara
- Roberto André
- Robertson David L.
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
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- Roessler Bernhard
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- Rusmawatiningtyas Desy
- Russell Clark D.
- Ryan Maeve
- Ryan Maria
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- Saba Isabela
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- Sandhu Gyan
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- Sandulescu Oana
- Sanharawi Mohamed El
- Santo Catarina Espírito
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- Sarfo-Mensah Shirley
- Sarmiento Iam Claire E.
- Sarton Benjamine
- Satya Ankana
- Satyapriya Sree
- Satyawati Rumaisah
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- Saw Yen Tsen
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- Scicluna Brendan
- Scott Janet T.
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvarajoo Mageswari
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G.
- Senian Rasidah Bt
- Senneville Eric
- Sepulveda Claudia
- Sequeira Filipa
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- Shadowitz Ellen
- Shahidan Syamin Asyraf
- Shamsah Mohammad
- Shankar Anuraj
- Sharjeel Shaikh
- Sharma Pratima
- Shaw Catherine A.
- Shaw Victoria
- Shetty Rajesh Mohan
- Shetty Rohan
- Shi Haixia
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- Shiekh Mohiuddin
- Shiga Takuya
- Shime Nobuaki
- Shimizu Hiroaki
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- Silva Maria Joao
- Silva Rogério
- Sin Wai Ching
- Sinatti Dario
- Singh Budha Charan
- Singh Moirangthem Bikram
- Singh Punam
- Sitompul Pompini Agustina
- Sivam Karisha
- Skeie Linda Gail
- Skogen Vegard
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- Sonntagbauer Michael
- Soom Azlan Mat
- Sotto Albert
- Soum Edouard
- Sousa Ana Chora
- Sousa Marta
- Souza-Dantas Vicente
- Sperry Alexandra
- Spinuzza Elisabetta
- Sriskandan Shiranee
- Stabler Sarah
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Steinsvik Trude
- Stienstra Ymkje
- Stiksrud Birgitte
- Stolz Eva
- Stone Amy
- Streinu-Cercel Adrian
- Streinu-Cercel Anca
- Stuart Ami
- Stuart David
- Su Richa
- Subekti Decy
- Suen Gabriel
- Suen Jacky Y.
- Sultana Asfia
- Summers Charlotte
- Supic Dubravka
- Suppiah Deepashankari
- Surovcová Magdalena
- Suwarti Atie
- Svistunov Andrey
- Sweeney Lisa Mc
- Syahrin Sarah
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taib Shahdattul Mawarni
- Talarek Ewa
- Taleb Sara
- Talsma Jelmer
- Tamisier Renaud
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tan Kim Keat
- Tan Le Van
- Tan Yan Chyi
- Tanaka Clarice
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M Azhari
- Tawfik Hassan
- Tedder Richard S.
- Tee Tze Yuan
- Teixeira João
- Tejada Sofia
- Tellier Marie-Capucine
- Teoh Sze Kye
- Teotonio Vanessa
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Téoulé François
- Thabit Alif Adlan Mohd
- Tham Zhang Duan
- Thangavelu Suvintheran
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thirumanickam Jananee
- Tho Leong Chin
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thurai Surain Raaj Thanga
- Thuy Duong Bich
- Thwaites Ryan S.
- Ticinesi Andrea
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S
- Timsit Jean-François
- Tissot Noémie
- Toh Jordan Zhien Yang
- Toki Maria
- Tonby Kristian
- Tonnii Sia Loong
- Torre Marta
- Torres Antoni
- Torres Margarida
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Trieu Huynh Trung
- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turgeon Alexis F.
- Turmel Jean-Marie
- Turnier Paul Le
- Turtle Lance C. W.
- Tveita Anders
- Twardowski Pawel
- Twillert Gitte Van
- Uchiyama Makoto
- Udayanga PG Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valentini Piero
- Valk Paul van der
- Valran Amélie
- Valzano Ilaria
- van Someren Greve Frank
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasconcelos Malte Kohns
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veen Ilonka van
- Veeran Shaminee
- Veislinger Aurélie
- Vekens Nicky Van Der
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Vishwanathan Gayatri
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vongsouvath Manivanh
- Vonkeman Harald
- Voort Peter Van der
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Werf Sylvie Van Der
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Patricia J
- Williams Virginie
- Willigen Hugo Van
- Wils Evert-Jan
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Xin Ci
- Wong Yew Sing
- Wright Natalie
- Xian Gan Ee
- Xian Lim Saio
- Xuan Kuan Pei
- Xynogalas Ioannis
- Yacoub Sophie
- Yakop Siti Rohani Binti Mohd
- Yamazaki Masaki
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yiaye Touxiong
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zabert Gustavo E
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zaidan Nor Zaila Binti
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zawadka Konrad
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Publication date
- 16/07/2024
- Field of study
By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients