Use of chosen methods of production management in a certain plant

The thesis deals with logistic processes in a chosen brush company. The aim of this thesis is analysis of used methods of management of a material and information flow which are dependent on a production program and improvement.There were carried on analysis off lows and relations with suppliers and buyers. Next there were mentioned a relation between flows and logistic center.Evaluations and recommendations are included in all the chapters of the thesis

Logistics in a chosen manufacturing concern

Bachelor work deals with an analysis of logistical activities in a company called Kartáčovny, Inc based in Pelhřimov. The company with a long tradition in the branch deals with production and sale of brush goods. After the introduction of the company including an analysis of competition I came to an identification of a present marketing strategy which tries to keep the current market positions. I suggest extending the webside by adding an e-shop which would suitably complete it. Then I dealt with an analysis of a logistical chain. It is a traditional logistical chain with discontinuous flow where material flow works on push principle. The disadvantage of this logistical chain is the necessity of keeping big reserves of material,semi-finished goods and products. In consideration of this amount of reserves and changing of variable and fixed expenses, there should be carried out more frequent count of an optimal production rate of a single product. I also focused on a suitable lay-out of buildings, work places equipment and transport expenses to reduce the necessity of a frequent transport in a company area. I did not find any serious faults in work places during my visit. I also praise the general lighting of work rooms by daylight, which makes a pleasant atmosphere and does not become a stressful factor as in case of artificial lighting . After a detailed research of routes, number of contacts, distances and transport expenses among buildings (work rooms) in the company area, I found out the possibility to save as much as 162 216,80 CZK per year on transport expenses. This fact was demonstrated by CRAF method. I suggest building a new store instead of a present store of granulate II. Existing old store would be pulled down and replaced by this new store with a bigger capacity. I am sure that building a new store would bring many positives which are worth considering

Robust monitoring of CAPM portfolio betas II

In this work, we extend our study in Chochola et al. [7] and propose some robust sequential procedure for the detection of structural breaks in a Functional Capital Asset Pricing Model (FCAPM). The procedure is again based on M-estimates and partial weighted sums of M-residuals and robustifies the approach of Aue et al. [3], in which ordinary least squares (OLS) estimates have been used. Similar to Aue et al. [3], and in contrast to Chochola et al. [7], high-frequency data can now also be taken into account. The main results prove some null asymptotics for the suggested test as well as its consistency under local alternatives. In addition to the theoretical results, some conclusions from a small simulation study together with an application to a real data set are presented in order to illustrate the finite sample performance of our monitoring procedure. (C) 2014 Elsevier Inc. All rights reserved

Direct and Indirect Biomimetic Peptide Modification of Alginate: Efficiency, Side Reactions, and Cell Response

In the fast-developing field of tissue engineering there is a constant demand for new materials as scaffolds for cell seeding, which can better mimic a natural extracellular matrix as well as control cell behavior. Among other materials, polysaccharides are widely used for this purpose. One of the main candidates for scaffold fabrication is alginate. However, it lacks sites for cell adhesion. That is why one of the steps toward the development of suitable scaffolds for cells is the introduction of the biofunctionality to the alginate structure. In this work we focused on bone-sialoprotein derived peptide (TYRAY) conjugation to the molecule of alginate. Here the comparison study on four different approaches of peptide conjugation was performed including traditional and novel modification methods, based on 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxy succinimide (EDC/NHS), 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride (DMTMM), thiol-Michael addition and Cu-catalyzed azide–alkyne cycloaddition reactions. It was shown that the combination of the alginate amidation with the use of and subsequent Cu-catalyzed azide–alkyne cycloaddition led to efficient peptide conjugation, which was proven with both NMR and XPS methods. Moreover, the cell culture experiment proved the positive effect of peptide presence on the adhesion of human embryonic stem cells

The effect of renal denervation in an experimental model of chronic renal insufficiency, The REmnant kidney Denervation In Pigs study (REDIP study)

Abstract Background Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabetes mellitus and chronic renal insufficiency among others. Previous trials showed conflicting but promising results, but the real benefits of RDN are still under investigation. Patients with renal insufficiency and resistant hypertension are proposed to be a good target for this therapy due to excessive activation of renal sympathetic drive. However, only limited number of studies showed benefits for these patients. We hypothesize that in our experimental model of chronic kidney disease (CKD) due to ischemia with increased activity of the renin–angiotensin–aldosterone system (RAAS), renal denervation can have protective effects by slowing or blocking the progression of renal injury. Methods An experimental biomodel of chronic renal insufficiency induced by ischemia was developed using selective renal artery embolization (remnant kidney porcine model). 27 biomodels were assessed. Renal denervation was performed in 19 biomodels (denervated group), and the remaining were used as controls (n = 8). The extent of renal injury and reparative process between the two groups were compared and assessed using biochemical parameters and histological findings. Results Viable remnant kidney biomodels were achieved and maintained in 27 swine. There were no significant differences in biochemical parameters between the two groups at baseline. Histological assessment proved successful RDN procedure in all biomodels in the denervated group. Over the 7-week period, there were significant increases in serum urea, creatinine, and aldosterone concentration in both groups. The difference in urea and creatinine levels were not statistically significant between the two groups. However, the level of aldosterone in the denervated was significantly lower in comparison to the controls. Histological assessment of renal arteries showed that RDN tends to produce more damage to the arterial wall in comparison to vessels in subjects that only underwent RAE. In addition, the morphological damage of kidneys, which was expressed as a ratio of damaged surface (or scar) to the overall surface of kidney, also did not show significant difference between groups. Conclusions In this study, we were not able to show significant protective effect of RDN alone on ischemic renal parenchymal damage by either laboratory or histological assessments. However, the change in aldosterone level shows some effect of renal denervation on the RAAS system. We hypothesize that a combined blockade of the RAAS and the sympathetic system could provide more protective effects against acute ischemia. This has to be further investigated in future studies