Haemophilia in Zambian children.

Haemophilia in Black people.Haemophilia is not as uncommon in Black people as was previously thought (Bullock and Johnson 1957, Gelfand 1945). Several cases of haemophilia have been reported in Africa (Forbes et al 1966, Comperts et al 1969, Robin 1964, Essien and Adeloye 1972). In Zambia, Traug (1970) reported a single case of classical haemophilia in the first issue of the Zambia Paediatric Journal. Twelve cases of classical haemophilia seen during a two-year period (1973-1975) are reported here for the purpose of documentation and to bring to the attention of Medical Practitioners that this disease does occur in the countryOffice of Global AIDS/US Department of Stat

Impact of educational intervention regarding oral rehydration solution and zinc for management of diarrhoea among mothers of urban slums of Ahmedabad city, Gujarat, India: an interventional study

Background: Diarrhoea is one of the leading causes of morbidity and mortality among under-five children. Timely management of the children with oral rehydration solution (ORS) has substantially declined the mortality and morbidity from acute infectious diarrhea. The use of ORS largely depends on the level of knowledge and attitude of mothers. Mothers’ knowledge about diarrhoea can be improved through educational interventions. The objective of the study was to assess knowledge of mothers of urban slums of Ahmedabad city of Gujarat regarding ORS and Zinc for management of diarrhoea before and after training.Methods: This Interventional study was conducted among purposively selected 100 mothers of under five children of urban slums of Ahmedabad city of Gujarat, India during June to August 2011. After taking verbal consent, baseline knowledge of mothers regarding ORS and Zinc for management of diarrhoea was assessed by pre-designed, pre-tested and semi structured questionnaire. Single educational interventional training for 45 minutes was given to selected mothers Pre and post training assessment was done by scoring method and also mean, standard deviation, Wilcoxon sign rank test were applied.Results: Almost 83% of the mothers could define diarrhoea as the passage of watery stools three or more times a day, this knowledge was significantly increased to 100% after the training. Baseline knowledge of the mothers regarding causes of diarrhoea in children, signs and symptoms of dehydration in children, Correct method of preparation of ORS and importance of zinc therapy along with ORS was 4%, 22%, 39% and 26% respectively which was significantly increased to 73%, 90%, 89% and 76% respectively after the intervention.Conclusions: Knowledge of the mothers of under-five children regarding causes of diarrhoea, signs and symptoms of diarrhoea, correct method of preparation of ORS and importance of zinc therapy along with ORS has been significantly increased after intervention

Maternal micronutrient status and decreased growth of Zambian infants born during and after the maize price increases resulting from the southern African drought of 2001-2002.

OBJECTIVE: To investigate the effects on maternal micronutrient status and infant growth of the increased maize prices that resulted from the southern African drought of 2001-2002. DESIGN: Longitudinal cohort study. SETTING: A maternal and child health clinic in Lusaka, Zambia. SUBJECTS: Maternal and infant health and nutrition data and maternal plasma were being collected for a study of breast-feeding and postpartum health. Samples and data were analysed according to whether they were collected before (June to December 2001), during (January 2002 to April 2003) or after (May 2003 to January 2004) the period of increased maize price. Season and maternal HIV status were controlled for in analyses. RESULTS: Maize price increases were associated with decreased maternal plasma vitamin A during pregnancy (P = 0.028) and vitamin E postpartum (P = 0.042), with the lowest values among samples collected after May 2003 (vitamin A: 0.96 micromol l(-1), 95% confidence interval (CI) 0.84-1.09, n = 38; vitamin E: 30.8 micromol mmol(-1) triglycerides, 95% CI 27.2-34.8, n = 64) compared with before January 2002 (vitamin A: 1.03 micromol l(-1), 95% CI 0.93-1.12, n = 104; vitamin E: 38.9 micromol mmol(-1) triglycerides, 95% CI 34.5-43.8, n = 47). There were no significant effects of sampling date on maternal weight, haemoglobin or acute-phase proteins and only marginal effects on infant weight. Infant length at 6 and 16 weeks of age decreased progressively throughout the study (P-values for time of data collection were 0.51 at birth, 0.051 at 6 weeks and 0.026 at 16 weeks). CONCLUSIONS: The results show modest effects of the maize price increases on maternal micronutrient status. The most serious consequence of the price increases is likely to be the increased stunting among infants whose mothers experienced high maize prices while pregnant. During periods of food shortages it might be advisable to provide micronutrient supplements even to those who are less food-insecure

Neuroblastoma - An Unusual Presentation

Presentation of a case of NeuroblastomaNeuroblastoma is relatively a common malignant solid tumour in childhood. Half of the cases occur in children two years of age and younger and three quarters before 4 years of age. Neuroblastoma develops from neural crest tissue. The first clinical manifestation is often due to metastatic lesions which minic other conditions so well that the diagnosis may be difficult. A case of Neuroblastoma with an unusual presentation with persistant haemothorax has been reported and discussed.Office of Global AIDS/US Department of State

The relentless spread of tuberculosis in Zambia - trends over the past 37 years (1964- 2000)

Objective. To review trends in the rates of tuberculosis (TB) case notifications over a 37-year period.Design. A retrospective study of Ministry of Health records on TB notifications between 1 January 1964 and 31 December 2000.Setting. Zambia, sub-Saharan Africa.Methods. Retrospective analysis of case-notification data for TB of the Zambia Ministry of Health annual returns.Outcome measures. Annual TB case-notification rates and trends over the past 37 years.Results. TB case-notification data from 1964 to 2000 show a 12-fold increase over the past two decades, and apparent gains in controlling TB seen in the 1960s and 1970s have been reversed over the past two decades. A stable situation during the period 1964 - 1984 (case-notification rate remained around 100 per 100 000 population) was followed by an exponential increase since the mid-1980s. The absolute number of new TBcases increased from 8 246 in 1985 (124/100 000) to 38 863 (409/100 000) in 1996 and 52 000 (512/100 000) in 2000. Comparison of case-notification rates over the past 2 decades with neighbouring countries (Zimbabwe, Malawi and Tanzania) show that Zambia has one of the highest case notification rates in the region.Conclusions. Zambia, like many countries in Africa, is in the midst of a serious TB epidemic and there are no signs that it is abating. This increase was most likely due to the impact of the HIV / AIDS epidemic and subsequent breakdown of TB services. Concerted donor-government efforts should invest appropriately in long-term plans for TB control

Tuberculous Manifestations in Children

Tuberculosis a chronic bacterial disease that still ranks high as a public health problem.Tuberculosis is a chronic bacterial disease that still ranks high as a public health problem. It occupied the 13th position among the 21 communicable diseases considered as priority problems in Africa, (Buna - 1977). Manifestations of primary tuberculosis occur mainly in children. There is a great paucity of data as to its various modes of presentation in children in this country. This paper records the pattern of tuberculosis observed in children, in the University Teaching Hospital (UTH), Lusaka, and the same is compared with other countries. An analysis of 110 cases of primary tuberculosis in Zambian children revealed that 47% of them had protein energy malnutrition. Of an pulmonary manifestations, simple primary tuberculosis was predominant followed by segmental lesions. A high incidence of extra pulmonary involvement mainly tuberculous lymphadenitis was observed. Previous BCG inoculation was not protective in 37 (33.6%) children.Office of Global AIDS/US Department of State

Tuberculosis and pregnancy

Tuberculosis and pregnancyTuberculosis is a disease of antiquities and it has been there since medieval times though according to literature, It is no older than the first conception of Adam's wife. Despite the extensive studies on tuberculosis and it being declared a global emergency, very little literature from the developing world is available on the interaction of this disease and pregnancy. There is a serious lack of information form those countries that bear the greatest burden of the disease particularly southern Africa where the duo epidemic of tuberculoses and HiV threaten the post independence gains in education, health, economic and other sectors of the economy, The scanty information on the impact of tuberculosis- a disease with effective chemotherapy- on pregnancy raises serious ethical and moral issues, which this paper will attempt to address.Office of Global AIDS/US Department of State

On-Farm Evaluation of Pearl Millet Varieties in Malawi for Farmer Preferences, Grain Yield, and Food Quality Traits

Dunng the 3993194 season two rypes ofon.fann rnah (research-managed and fanner.ma~ged], were conducred in 66 janners' fields tn the Shtre Vallq to veniy crop perfonnance and to expose new uanerles to the farming community Both inair were lmplemenred by farmers Three new pearl miller varieties (SDMV 89004, SDMV 89005, and ICMV 88908j and rwo controls (N~genan Compostre-rail [NC rail], and farmers' local landrace vaneties [LLl'jj were e~,aluatedjorplanta nd gram traits preferred by farmers, yield porenrral, andfor thetr acceptablltty as food. Varrerv SDM 1'89004 had the hia-herr n-raln v.~elds I 95 r ha ' when research. managedand I 47 f ha ' whenjarmer.ma~ged Under research-management rhe three test vanerier and NC-tall 'aer,ion ned szmilarlv and were suoerior ro the LLV used, whereas, under jarmer.managed ma&, rhr rhrer terr wnerles produced s~milar~ieldthsa t were supenor to both NC.ral1 and the LLV Ofthe 164 farmers who evaluated the pearl millet on.fann trraLforplant and groin rraits, the malonty preferred iCMV 88908 as rhe~rfavonref,o llowed by SDMV 89004, and SDMV 89005 based on field obsen,ations All the tmriprtes uer? ranked berrer than the LLVfor <ram rrairs (grain size, dehulltng, grtnding ease) However, far food taste NC-tall was the most preferred, followed by SDMV 89W5, SDMV 89004, and ICMV 88908. These results, and those from previous years, tnd~care rhat farmers prefer the new vanetres because of their h~gh grain yeld, good grain traits, and acceptabiliry as jood (taste) These varietter wll therefore be recomvnended soon for release tn Mala