11,411 research outputs found
Aeroelastic analysis for propellers - mathematical formulations and program user's manual
Mathematical development is presented for a specialized propeller dedicated version of the G400 rotor aeroelastic analysis. The G400PROP analysis simulates aeroelastic characteristics particular to propellers such as structural sweep, aerodynamic sweep and high subsonic unsteady airloads (both stalled and unstalled). Formulations are presented for these expanded propeller related methodologies. Results of limited application of the analysis to realistic blade configurations and operating conditions which include stable and unstable stall flutter test conditions are given. Sections included for enhanced program user efficiency and expanded utilization include descriptions of: (1) the structuring of the G400PROP FORTRAN coding; (2) the required input data; and (3) the output results. General information to facilitate operation and improve efficiency is also provided
Factors influencing dentists’ willingness to treat Medicaid-enrolled adolescents
Objectives: To identify factors influencing dentists’ willingness to treat
Medicaid-enrolled adolescents with intellectual and developmental disabilities in
Washington state.
Data sources: Primary data were collected by a survey instrument administered
in 2017 to general and pediatric dentists who were Medicaid providers (N = 512).
Methods: We administered a 40-item survey, which included 20 hypothetical scenarios
involving a 12-year-old Medicaid-enrolled adolescent. Based on the characteristics
of the potential patient, dentists were asked to rate their willingness to
treat (1 = very likely; 5 = very unlikely). We used conjoint analytic techniques to
examine the relative importance of six adolescent- and family-level factors
(e.g., severity of intellectual and/or developmental disability [IDD], sugar intake,
toothbrushing, caregiver beliefs about fluoride, restorative needs, appointment
keeping) and state Medicaid reimbursement level (35 percent, 55 percent, 85 percent
of usual, customary, and reasonable amount). Analyses focused on data from
178 dentists with complete and varied responses to the scenarios.
Results: The mean age of participants was 53.8 ± 10.5 years and 10.7 percent
were pediatric dentists. The holdouts correlation statistics indicated excellent fit
for the conjoint model (Pearson’s R = 0.99, P < 0.0001; Kendall’s tau = 0.89,
P < 0.0001). Reimbursement level and appointment keeping were the most
important factors in dentists’ willingness to treat Medicaid-enrolled adolescents
(importance scores of 26.7 and 25.7, respectively). Restorative needs, caregiver
beliefs about fluoride, and IDD severity were the next most important (importance
scores of 15.4, 10.6, and 8.1, respectively). Sugar intake and toothbrushing
behaviors were the least important.
Conclusions: Reimbursement and appointment keeping were the most important
determinants of dentists’ willingness to treat Medicaid-enrolled adolescents
with IDD
Models of Social Groups in Blogosphere Based on Information about Comment Addressees and Sentiments
This work concerns the analysis of number, sizes and other characteristics of
groups identified in the blogosphere using a set of models identifying social
relations. These models differ regarding identification of social relations,
influenced by methods of classifying the addressee of the comments (they are
either the post author or the author of a comment on which this comment is
directly addressing) and by a sentiment calculated for comments considering the
statistics of words present and connotation. The state of a selected blog
portal was analyzed in sequential, partly overlapping time intervals. Groups in
each interval were identified using a version of the CPM algorithm, on the
basis of them, stable groups, existing for at least a minimal assumed duration
of time, were identified.Comment: Gliwa B., Ko\'zlak J., Zygmunt A., Models of Social Groups in
Blogosphere Based on Information about Comment Addressees and Sentiments, in
the K. Aberer et al. (Eds.): SocInfo 2012, LNCS 7710, pp. 475-488, Best Paper
Awar
Spectral properties and magneto-optical excitations in semiconductor double-rings under Rashba spin-orbit interaction
We have numerically solved the Hamiltonian of an electron in a semiconductor
double ring subjected to the magnetic flux and Rashba spin-orbit interaction.
It is found that the Aharonov-Bohm energy spectrum reveals multi-zigzag
periodic structures. The investigations of spin-dependent electron dynamics via
Rabi oscillations in two-level and three-level systems demonstrate the
possibility of manipulating quantum states. Our results show that the optimal
control of photon-assisted inter-ring transitions can be achieved by employing
cascade-type and -type transition mechanisms. Under chirped pulse
impulsions, a robust and complete transfer of an electron to the final state is
shown to coincide with the estimation of the Landau-Zener formula.Comment: RevTex, 9 pages, 5 figure
Student understanding of rotational and rolling motion concepts
We investigated the common difficulties that students have with concepts
related to rotational and rolling motion covered in the introductory physics
courses. We compared the performance of calculus- and algebra-based
introductory physics students with physics juniors who had learned rotational
and rolling motion concepts in an intermediate level mechanics course.
Interviews were conducted with six physics juniors and ten introductory
students using demonstration-based tasks. We also administered free-response
and multiple-choice questions to a large number of students enrolled in
introductory physics courses, and interviewed six additional introductory
students on the test questions (during the test design phase). All students
showed similar difficulties regardless of their background, and higher
mathematical sophistication did not seem to help acquire a deeper
understanding. We found that some difficulties were due to related difficulties
with linear motion, while others were tied specifically to the more intricate
nature of rotational and rolling motion.Comment: 23 pages, 3 figures, 2 tables; it includes a multiple-choice test (in
Appendix B
A targeted gene panel that covers coding, non-coding and short tandem repeat regions improves the diagnosis of patients with neurodegenerative diseases
Genetic testing for neurodegenerative diseases (NDs) is highly challenging because of genetic heterogeneity and overlapping manifestations. Targeted-gene panels (TGPs), coupled with next-generation sequencing (NGS), can facilitate the profiling of a large repertoire of ND-related genes. Due to the technical limitations inherent in NGS and TGPs, short tandem repeat (STR) variations are often ignored. However, STR expansions are known to cause such NDs as Huntington\u27s disease and spinocerebellar ataxias type 3 (SCA3). Here, we studied the clinical utility of a custom-made TGP that targets 199 NDs and 311 ND-associated genes on 118 undiagnosed patients. At least one known or likely pathogenic variation was found in 54 patients; 27 patients demonstrated clinical profiles that matched the variants; and 16 patients whose original diagnosis were refined. A high concordance of variant calling were observed when comparing the results from TGP and whole-exome sequencing of four patients. Our in-house STR detection algorithm has reached a specificity of 0.88 and a sensitivity of 0.82 in our SCA3 cohort. This study also uncovered a trove of novel and recurrent variants that may enrich the repertoire of ND-related genetic markers. We propose that a combined comprehensive TGPs-bioinformatics pipeline can improve the clinical diagnosis of NDs
The Case for Dynamic Models of Learners' Ontologies in Physics
In a series of well-known papers, Chi and Slotta (Chi, 1992; Chi & Slotta,
1993; Chi, Slotta & de Leeuw, 1994; Slotta, Chi & Joram, 1995; Chi, 2005;
Slotta & Chi, 2006) have contended that a reason for students' difficulties in
learning physics is that they think about concepts as things rather than as
processes, and that there is a significant barrier between these two
ontological categories. We contest this view, arguing that expert and novice
reasoning often and productively traverses ontological categories. We cite
examples from everyday, classroom, and professional contexts to illustrate
this. We agree with Chi and Slotta that instruction should attend to learners'
ontologies; but we find these ontologies are better understood as dynamic and
context-dependent, rather than as static constraints. To promote one
ontological description in physics instruction, as suggested by Slotta and Chi,
could undermine novices' access to productive cognitive resources they bring to
their studies and inhibit their transition to the dynamic ontological
flexibility required of experts.Comment: The Journal of the Learning Sciences (In Press
Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7
<p>Abstract</p> <p>Background</p> <p>Nucleotide pyrophosphatase/phosphodiesterase 7 (NPP7) is the only member of the mammalian NPP enzyme family that has been confirmed to act as a sphingomyelinase, hydrolyzing sphingomyelin (SM) to form phosphocholine and ceramide. NPP7 additionally hydrolyzes lysophosphatidylcholine (LPC), a substrate preference shared with the NPP2/autotaxin(ATX) and NPP6 mammalian family members. This study utilizes a synergistic combination of molecular modeling validated by experimental site-directed mutagenesis to explore the molecular basis for the unique ability of NPP7 to hydrolyze SM.</p> <p>Results</p> <p>The catalytic function of NPP7 against SM, LPC, platelet activating factor (PAF) and para-nitrophenylphosphorylcholine (pNPPC) is impaired in the F275A mutant relative to wild type NPP7, but different impacts are noted for mutations at other sites. These results are consistent with a previously described role of F275 to interact with the choline headgroup, where all substrates share a common functionality. The L107F mutation showed enhanced hydrolysis of LPC, PAF and pNPPC but reduced hydrolysis of SM. Modeling suggests this difference can be explained by the gain of cation-pi interactions with the choline headgroups of all four substrates, opposed by increased steric crowding against the sphingoid tail of SM. Modeling also revealed that the long and flexible hydrophobic tails of substrates exhibit considerable dynamic flexibility in the binding pocket, reducing the entropic penalty that might otherwise be incurred upon substrate binding.</p> <p>Conclusions</p> <p>Substrate recognition by NPP7 includes several important contributions, ranging from cation-pi interactions between F275 and the choline headgroup of all substrates, to tail-group binding pockets that accommodate the inherent flexibility of the lipid hydrophobic tails. Two contributions to the unique ability of NPP7 to hydrolyze SM were identified. First, the second hydrophobic tail of SM occupies a second hydrophobic binding pocket. Second, the leucine residue present at position 107 contrasts with a conserved phenylalanine in NPP enzymes that do not utilize SM as a substrate, consistent with the observed reduction in SM hydrolysis by the NPP7-L107F mutant.</p
Broadband energy-efficient optical modulation by hybrid integration of silicon nanophotonics and organic electro-optic polymer
Silicon-organic hybrid integrated devices have emerging applications ranging
from high-speed optical interconnects to photonic electromagnetic-field
sensors. Silicon slot photonic crystal waveguides (PCWs) filled with
electro-optic (EO) polymers combine the slow-light effect in PCWs with the high
polarizability of EO polymers, which promises the realization of
high-performance optical modulators. In this paper, a broadband,
power-efficient, low-dispersion, and compact optical modulator based on an EO
polymer filled silicon slot PCW is presented. A small voltage-length product of
V{\pi}*L=0.282Vmm is achieved, corresponding to an unprecedented record-high
effective in-device EO coefficient (r33) of 1230pm/V. Assisted by a backside
gate voltage, the modulation response up to 50GHz is observed, with a 3-dB
bandwidth of 15GHz, and the estimated energy consumption is 94.4fJ/bit at
10Gbit/s. Furthermore, lattice-shifted PCWs are utilized to enhance the optical
bandwidth by a factor of ~10X over other modulators based on
non-band-engineered PCWs and ring-resonators.Comment: 12 pages, 4 figures, SPIE Photonics West Conference 201
Star formation rate indicators in the Sloan Digital Sky Survey
The Sloan Digital Sky Survey (SDSS) first data release provides a database of
106000 unique galaxies in the main galaxy sample with measured spectra. A
sample of star-forming (SF) galaxies are identified from among the 3079 of
these having 1.4 GHz luminosities from FIRST, by using optical spectral
diagnostics. Using 1.4 GHz luminosities as a reference star formation rate
(SFR) estimator insensitive to obscuration effects, the SFRs derived from the
measured SDSS Halpha, [OII] and u-band luminosities, as well as far-infrared
luminosities from IRAS, are compared. It is established that straightforward
corrections for obscuration and aperture effects reliably bring the SDSS
emission line and photometric SFR estimates into agreement with those at 1.4
GHz, although considerable scatter (~60%) remains in the relations. It thus
appears feasible to perform detailed investigations of star formation for large
and varied samples of SF galaxies through the available spectroscopic and
photometric measurements from the SDSS. We provide herein exact prescriptions
for determining the SFR for SDSS galaxies. The expected strong correlation
between [OII] and Halpha line fluxes for SF galaxies is seen, but with a median
line flux ratio F_[OII]/F_Halpha=0.23, about a factor of two smaller than that
found in the sample of Kennicutt (1992). This correlation, used in deriving the
[OII] SFRs, is consistent with the luminosity-dependent relation found by
Jansen et al. (2001). The median obscuration for the SDSS SF systems is found
to be A_Halpha=1.2 mag, while for the radio detected sample the median
obscuration is notably higher, 1.6 mag, and with a broader distribution.Comment: Accepted for publication in ApJ, 40 pages, 26 figure
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