124 research outputs found
Evolution of population with sexual and asexual reproduction in changing environment
Using a lattice model based on Monte Carlo simulations, we study the role of
the reproduction pattern on the fate of an evolving population. Each individual
is under the selection pressure from the environment and random mutations. The
habitat ("climate") is changing periodically. Evolutions of populations
following two reproduction patterns are compared, asexual and sexual. We show,
via Monte Carlo simulations, that sexual reproduction by keeping more
diversified populations gives them better chances to adapt themselves to the
changing environment. However, in order to obtain a greater chance to mate, the
birth rate should be high. In the case of low birth rate and high mutation
probability there is a preference for the asexual reproduction.Comment: 11 pages including figs., for Int. J. Mod. Phys. C 15, issue 2 (2004
Evaluation of Stability and Biocompatibility of Chitosan/Sodium Tripolyphosphate and Chitosan/Flaxseed Gum Composite Nanoparticles Loaded with Bighead Carp Peptides
Chitosan nanoparticle is becoming an excellent carrier for the delivery of bioactive components due to the advantages of simple preparation, low cost and high biocompatibility. Previous studies have shown that chitosan/sodium tripolyphosphate (CS/TPP) and chitosan/flaxseed gum (CS/FG) nanoparticles loaded with bighead carp peptides (BCP) have the advantages of small particle size, high encapsulation rate and significant slow-release effect. This study explored the effects of ionic strength, pH, simulated digestion and storage time on the preparation of chitosan/sodium tripolyphosphate (CS/TPP-BCP) and chitosan/flaxseed gum (CS/FG-BCP) nanoparticles, and evaluated the extracellular lactate dehydrogenase content and antioxidant capacity in vivo of Caco-2 cells treated with the chitosan nanoparticles and their cellular uptake. The results showed that the two kinds of chitosan nanoparticles were stable under acidic conditions and sensitive to a solution with opposite charges. The stability of the nanoparticles loaded with bighead peptides was higher than that of free peptides and both nanoparticles showed higher biocompatibility and cell uptake
Research progress on deep learning in magnetic resonance imagingâbased diagnosis and treatment of prostate cancer: a review on the current status and perspectives
Multiparametric magnetic resonance imaging (mpMRI) has emerged as a first-line screening and diagnostic tool for prostate cancer, aiding in treatment selection and noninvasive radiotherapy guidance. However, the manual interpretation of MRI data is challenging and time-consuming, which may impact sensitivity and specificity. With recent technological advances, artificial intelligence (AI) in the form of computer-aided diagnosis (CAD) based on MRI data has been applied to prostate cancer diagnosis and treatment. Among AI techniques, deep learning involving convolutional neural networks contributes to detection, segmentation, scoring, grading, and prognostic evaluation of prostate cancer. CAD systems have automatic operation, rapid processing, and accuracy, incorporating multiple sequences of multiparametric MRI data of the prostate gland into the deep learning model. Thus, they have become a research direction of great interest, especially in smart healthcare. This review highlights the current progress of deep learning technology in MRI-based diagnosis and treatment of prostate cancer. The key elements of deep learning-based MRI image processing in CAD systems and radiotherapy of prostate cancer are briefly described, making it understandable not only for radiologists but also for general physicians without specialized imaging interpretation training. Deep learning technology enables lesion identification, detection, and segmentation, grading and scoring of prostate cancer, and prediction of postoperative recurrence and prognostic outcomes. The diagnostic accuracy of deep learning can be improved by optimizing models and algorithms, expanding medical database resources, and combining multi-omics data and comprehensive analysis of various morphological data. Deep learning has the potential to become the key diagnostic method in prostate cancer diagnosis and treatment in the future
In Vivo
Aim. Dermatophytosis is one of the main fungal diseases in humans and animals all over the world. Galla chinensis, a traditional medicine, has various pharmacological effects. The goal of this study was to evaluate the treatment effect of Galla chinensis solution (GCS) on dermatophytosis-infected dogs (Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes, resp.). Methods. The treatment effects of GCS were evaluated by mycological cure rates and clinical score comprised of three indices, including inflammation, hair loss, and lesion scale. Results. The results showed that, in the three models of dermatophytosis, GCS significantly (P<0.05) improved skin lesions and fungal eradication. GCS (10% and 5%) had higher efficacy compared to the positive control (Tujingpi Tincture). The fungal eradication efficacy exceeds 85% after treatment with GCS (10%, 5%, and 2.5%) on day 14. Conclusion. The GCS has antidermatophytosis effect in dogs, which may be a candidate drug for the treatment of dermatophytosis
Unleashing novel horizons in advanced prostate cancer treatment: investigating the potential of prostate specific membrane antigen-targeted nanomedicine-based combination therapy
Prostate cancer (PCa) is a prevalent malignancy with increasing incidence in middle-aged and older men. Despite various treatment options, advanced metastatic PCa remains challenging with poor prognosis and limited effective therapies. Nanomedicine, with its targeted drug delivery capabilities, has emerged as a promising approach to enhance treatment efficacy and reduce adverse effects. Prostate-specific membrane antigen (PSMA) stands as one of the most distinctive and highly selective biomarkers for PCa, exhibiting robust expression in PCa cells. In this review, we explore the applications of PSMA-targeted nanomedicines in advanced PCa management. Our primary objective is to bridge the gap between cutting-edge nanomedicine research and clinical practice, making it accessible to the medical community. We discuss mainstream treatment strategies for advanced PCa, including chemotherapy, radiotherapy, and immunotherapy, in the context of PSMA-targeted nanomedicines. Additionally, we elucidate novel treatment concepts such as photodynamic and photothermal therapies, along with nano-theragnostics. We present the content in a clear and accessible manner, appealing to general physicians, including those with limited backgrounds in biochemistry and bioengineering. The review emphasizes the potential benefits of PSMA-targeted nanomedicines in enhancing treatment efficiency and improving patient outcomes. While the use of PSMA-targeted nano-drug delivery has demonstrated promising results, further investigation is required to comprehend the precise mechanisms of action, pharmacotoxicity, and long-term outcomes. By meticulous optimization of the combination of nanomedicines and PSMA ligands, a novel horizon of PSMA-targeted nanomedicine-based combination therapy could bring renewed hope for patients with advanced PCa
Effects of polysaccharide from Ophiopogon japonicus on immune response to Newcastle disease vaccine in chicken
Seismically Imaged Crustal Breakup in the Southwest Taiwan Basin of the Northeastern South China Sea Margin
Abstract The Southern Depression of the Southwest Taiwan Basin is an ENEâtrending wide rift in the northeastern South China Sea margin. Though known as highly thinned, the maximum degree of crustal extension remains unclear. Here, we present three NWâtrending multiâchannel seismic profiles crossing the depression askew, and another profile traversing it, all of which image the basement and Moho clearly. The basement deepens toward the rift axis while the Moho shoals toward the axis, indicating significant crustal thinning. Faults appear with only small throws and are usually untraceable to depth. As the integral fault offset seems insufficient to match the horizontal crustal extension, the high crustal thinning is mainly accommodated by detachment faults. Only smallâscale postârift magmatic bodies and sporadic sills are observed, and synârift magmatism is poor. The depression shows a recumbent Vâshaped valley opening to the northeast with the width increasing from 50 km on the southwestern profile to 96 km on the northeastern profile. Along the valley axis, the crust thins from 8.1 to 3.6 km and more thinner to the northeast, demonstrating enhanced extensional degree toward the northeast. A unique conchâshaped package (up to âŒ2 s twoâway travel time thick) with moderately coherent reflections is imaged atop the axial mantle on the northeastern profile. It was possibly formed by mantle exhumation, synârift sedimentary uplift, or volcanic eruption. All these possibilities indicate that the crust probably broke up there, which represents a special style of crustal thinning different from other magmaâpoor margins
Dynamic Response Enhancement and Fault Protection of Boost Converter-Fed Brushless DC Motor in Aerospace Applications
Susceptibility-Weighted Imaging Manifestations in the Brain of Wilson's Disease Patients.
It is well known that patients with Wilson's disease (WD) suffer copper metabolism disorder. However, recent studies point to an additional iron metabolism disorder in WD patients. The purpose of our study was to examine susceptibility-weighted imaging (SWI) manifestations of WD in the brains of WD patients.A total of 33 patients with WD and 18 normal controls underwent conventional MRI (Magnetic resonance imaging) and SWI. The phase values were measured on SWI-filtered phase images of the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus. Student's t-tests were used to compare the phase values between WD groups and normal controls.The mean phase values for the bilateral head of the caudate nuclei, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus were significantly lower than those in the control group (P < 0.001), and bilateral putamen was most strongly affected.There is paramagnetic mineralization deposition in brain gray nuclei of WD patients and SWI is an effective method to evaluate these structures
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