97 research outputs found
Modified Lund concept versus cerebral perfusion pressure-targeted therapy: a randomized controlled study in patients with secondary brain ischaemia
Accurate masses and radii of normal stars: modern results and applications
This paper presents and discusses a critical compilation of accurate,
fundamental determinations of stellar masses and radii. We have identified 95
detached binary systems containing 190 stars (94 eclipsing systems, and alpha
Centauri) that satisfy our criterion that the mass and radius of both stars be
known to 3% or better. To these we add interstellar reddening, effective
temperature, metal abundance, rotational velocity and apsidal motion
determinations when available, and we compute a number of other physical
parameters, notably luminosity and distance. We discuss the use of this
information for testing models of stellar evolution. The amount and quality of
the data also allow us to analyse the tidal evolution of the systems in
considerable depth, testing prescriptions of rotational synchronisation and
orbital circularisation in greater detail than possible before. The new data
also enable us to derive empirical calibrations of M and R for single (post-)
main-sequence stars above 0.6 M(Sun). Simple, polynomial functions of T(eff),
log g and [Fe/H] yield M and R with errors of 6% and 3%, respectively.
Excellent agreement is found with independent determinations for host stars of
transiting extrasolar planets, and good agreement with determinations of M and
R from stellar models as constrained by trigonometric parallaxes and
spectroscopic values of T(eff) and [Fe/H]. Finally, we list a set of 23
interferometric binaries with masses known to better than 3%, but without
fundamental radius determinations (except alpha Aur). We discuss the prospects
for improving these and other stellar parameters in the near future.Comment: 56 pages including figures and tables. To appear in The Astronomy and
Astrophysics Review. Ascii versions of the tables will appear in the online
version of the articl
A Model for the Detection of Moving Targets in Visual Clutter Inspired by Insect Physiology
We present a computational model for target discrimination based on intracellular recordings from neurons in the fly visual system. Determining how insects detect and track small moving features, often against cluttered moving backgrounds, is an intriguing challenge, both from a physiological and a computational perspective. Previous research has characterized higher-order neurons within the fly brain, known as ‘small target motion detectors’ (STMD), that respond robustly to moving features, even when the velocity of the target is matched to the background (i.e. with no relative motion cues). We recorded from intermediate-order neurons in the fly visual system that are well suited as a component along the target detection pathway. This full-wave rectifying, transient cell (RTC) reveals independent adaptation to luminance changes of opposite signs (suggesting separate ON and OFF channels) and fast adaptive temporal mechanisms, similar to other cell types previously described. From this physiological data we have created a numerical model for target discrimination. This model includes nonlinear filtering based on the fly optics, the photoreceptors, the 1st order interneurons (Large Monopolar Cells), and the newly derived parameters for the RTC. We show that our RTC-based target detection model is well matched to properties described for the STMDs, such as contrast sensitivity, height tuning and velocity tuning. The model output shows that the spatiotemporal profile of small targets is sufficiently rare within natural scene imagery to allow our highly nonlinear ‘matched filter’ to successfully detect most targets from the background. Importantly, this model can explain this type of feature discrimination without the need for relative motion cues
Injection-site reactions upon Kineret (anakinra) administration: experiences and explanations
Anakinra (Kineret), a recombinant form of human interleukin-1 (IL-1) receptor antagonist, is approved for the treatment of rheumatoid arthritis (RA) in combination with methotrexate. Kineret is self-administered by daily subcutaneous injections in patients with active RA. The mechanism of action of anakinra is to competitively inhibit the local inflammatory effects of IL-1. Kineret is generally safe and well tolerated and the only major treatment-related side effects that appear are skin reactions at the injection site. Due to the relatively short half-life of anakinra, daily injection of the drug is required. This, in combination with the comparably high rates of injection-site reactions (ISRs) associated with the drug, can become a problem for the patient. The present review summarises published data concerning ISRs associated with Kineret and provides some explanations as to their cause. The objective is also to present some clinical experiences of how the ISRs can be managed
Static-Memory-Hard Functions, and Modeling the Cost of Space vs. Time
A series of recent research starting with (Alwen and Serbinenko, STOC 2015) has deepened our understanding of the notion of memory-hardness in cryptography — a useful property of hash functions for deterring large-scale password-cracking attacks — and has shown memory-hardness to have intricate connections with the theory of graph pebbling. Definitions of memory-hardness are not yet unified in the somewhat nascent field of memory-hardness, however, and the guarantees proven to date are with respect to a range of proposed definitions. In this paper, we observe two significant and practical considerations that are not analyzed by existing models of memory-hardness, and propose new models to capture them, accompanied by constructions based on new hard-to-pebble graphs. Our contribution is two-fold, as follows.
First, existing measures of memory-hardness only account for dynamic memory usage (i.e., memory read/written at runtime), and do not consider static memory usage (e.g., memory on disk). Among other things, this means that memory requirements considered by prior models are inherently upper-bounded by a hash function’s runtime; in contrast, counting static memory would potentially allow quantification of much larger memory requirements, decoupled from runtime. We propose a new definition of static-memory-hard function (SHF) which takes static memory into account: we model static memory usage by oracle access to a large preprocessed string, which may be considered part of the hash function description. Static memory requirements are complementary to dynamic memory requirements: neither can replace the other, and to deter large-scale password-cracking attacks, a hash function will benefit from being both dynamic memory-hard and static-memory-hard. We give two SHF constructions based on pebbling. To prove static-memory-hardness, we define a new pebble game (“black-magic pebble game”), and new graph constructions with optimal complexity under our proposed measure. Moreover, we provide a prototype implementation of our first SHF construction (which is based on pebbling of a simple “cylinder” graph), providing an initial demonstration of practical feasibility for a limited range of parameter settings.
Secondly, existing memory-hardness models implicitly assume that the cost of space and time are more or less on par: they consider only linear ratios between the costs of time and space. We propose a new model to capture nonlinear time-space trade-offs: e.g., how is the adversary impacted when space is quadratically more expensive than time? We prove that nonlinear tradeoffs can in fact cause adversaries to employ different strategies from linear tradeoffs. Finally, as an additional contribution of independent interest, we present an asymptotically tight graph construction that achieves the best possible space complexity up to log log n-factors for an existing memory-hardness measure called cumulative complexity in the sequential pebbling model
Solid-state MAS NMR, TEM, and TGA studies of structural hydroxyl groups and water in nanocrystalline apatites prepared by dry milling
Constraining the electric charges of some astronomical bodies in Reissner-Nordstrom spacetimes and generic r^-2-type power-law potentials from orbital motions
We put model-independent, dynamical constraints on the net electric charge Q
of some astronomical and astrophysical objects by assuming that their exterior
spacetimes are described by the Reissner-Nordstroem metric, which induces an
additional potential U_RN \propto Q^2 r^-2. Our results extend to other
hypothetical power-law interactions inducing extra-potentials U_pert = r^-2 as
well (abridged).Comment: LaTex2e, 16 pages, 3 figures, no tables, 128 references. Version
matching the one at press in General Relativity and Gravitation (GRG). arXiv
admin note: substantial text overlap with arXiv:1112.351
Dynamics of Disks and Warps
This chapter reviews theoretical work on the stellar dynamics of galaxy
disks. All the known collective global instabilities are identified, and their
mechanisms described in terms of local wave mechanics. A detailed discussion of
warps and other bending waves is also given. The structure of bars in galaxies,
and their effect on galaxy evolution, is now reasonably well understood, but
there is still no convincing explanation for their origin and frequency. Spiral
patterns have long presented a special challenge, and ideas and recent
developments are reviewed. Other topics include scattering of disk stars and
the survival of thin disks.Comment: Chapter accepted to appear in Planets, Stars and Stellar Systems, vol
5, ed G. Gilmore. 32 pages, 17 figures. Includes minor corrections made in
proofs. Uses emulateapj.st
The Confrontation between General Relativity and Experiment
The status of experimental tests of general relativity and of theoretical
frameworks for analysing them is reviewed. Einstein's equivalence principle
(EEP) is well supported by experiments such as the Eotvos experiment, tests of
special relativity, and the gravitational redshift experiment. Future tests of
EEP and of the inverse square law are searching for new interactions arising
from unification or quantum gravity. Tests of general relativity at the
post-Newtonian level have reached high precision, including the light
deflection, the Shapiro time delay, the perihelion advance of Mercury, and the
Nordtvedt effect in lunar motion. Gravitational-wave damping has been detected
in an amount that agrees with general relativity to better than half a percent
using the Hulse-Taylor binary pulsar, and other binary pulsar systems have
yielded other tests, especially of strong-field effects. When direct
observation of gravitational radiation from astrophysical sources begins, new
tests of general relativity will be possible.Comment: 89 pages, 8 figures; an update of the Living Review article
originally published in 2001; final published version incorporating referees'
suggestion
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