Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions.

Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer. In our previous study, selected Chinese medicines traditionally used to treat hyperpigmentation were tested for anti-hyperpigmentary effects using a melan-a cell culture model. Among the tested chemical compounds, 4-ethylresorcinol, 4-ethylphenol and 1-tetradecanol were found to possess hypopigmentary effects. Western blot analysis, reverse transcriptase polymerase chain reaction (RT-PCR), cyclic adenosine monophosphate (cAMP) assay, protein kinase A (PKA) activity assay, tyrosinase inhibition assay and lipid peroxidation inhibition assay were performed to reveal the underlying cellular and molecular mechanisms of the hypopigmentary effects. 4-Ethylresorcinol and 4-ethylphenol attenuated mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation. 1-Tetradecanol was able to attenuate protein expression of tyrosinase. The hypopigmentary actions of 4-ethylresorcinol, 4-ethylphenol and 1-tetradecanol were associated with regulating downstream proteins along the PKA pathway. 4-Ethylresorcinol was more effective in inhibiting melanin synthesis when compared to 4-ethylphenol and 1-tetradecanol

Structure propagation for zero-shot learning

The key of zero-shot learning (ZSL) is how to find the information transfer model for bridging the gap between images and semantic information (texts or attributes). Existing ZSL methods usually construct the compatibility function between images and class labels with the consideration of the relevance on the semantic classes (the manifold structure of semantic classes). However, the relationship of image classes (the manifold structure of image classes) is also very important for the compatibility model construction. It is difficult to capture the relationship among image classes due to unseen classes, so that the manifold structure of image classes often is ignored in ZSL. To complement each other between the manifold structure of image classes and that of semantic classes information, we propose structure propagation (SP) for improving the performance of ZSL for classification. SP can jointly consider the manifold structure of image classes and that of semantic classes for approximating to the intrinsic structure of object classes. Moreover, the SP can describe the constrain condition between the compatibility function and these manifold structures for balancing the influence of the structure propagation iteration. The SP solution provides not only unseen class labels but also the relationship of two manifold structures that encode the positive transfer in structure propagation. Experimental results demonstrate that SP can attain the promising results on the AwA, CUB, Dogs and SUN databases

Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children

Untreated dental caries in Chinese pre-school children is common. This prospective controlled clinical trial investigated the effectiveness of topical fluoride applications in arresting dentin caries. Three hundred seventy-five children, aged 3-5 years, with carious upper anterior teeth were divided into five groups. Children in the first and second groups received annual applications of silver diamine fluoride solution (44,800 ppm F). Sodium fluoride varnish (22,600 ppm F) was applied every three months to the lesions of children in the third and fourth groups. For children in the first and third groups, soft carious tissues were removed prior to fluoride application. The fifth group was the control. Three hundred eight children were followed for 30 months. The respective mean numbers of arrested carious tooth surfaces in the five groups were 2.5, 2.8, 1.5, 1.5, and 1.3 (p < 0.001). Silver diamine fluoride was found to be effective in arresting dentin caries in primary anterior teeth in pre-school children.published_or_final_versio

A Spin-Isospin Dependent 3N Scattering Formalism in a 3D Faddeev Scheme

We have introduced a spin-isospin dependent three-dimensional approach for formulation of the three-nucleon scattering. Faddeev equation is expressed in terms of vector Jacobi momenta and spin-isospin quantum numbers of each nucleon. Our formalism is based on connecting the transition amplitude $T$ to momentum-helicity representations of the two-body $t$-matrix and the deuteron wave function. Finally the expressions for nucleon-deuteron elastic scattering and full breakup process amplitudes are presented.Comment: 17 page

Energy quantization in solution-processed layers of indium oxide and their application in resonant tunneling diodes

\u3cp\u3eThe formation of quantized energy states in ultrathin layers of indium oxide (In\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e) grown via spin coating and thermally annealed at 200°C in air is studied. Optical absorption measurements reveal a characteristic widening of the optical band gap with reducing In\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e layer thickness from ≈43 to ≈3 nm in agreement with theoretical predictions for an infinite quantum well. Through sequential deposition of In\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e and gallium oxide (Ga\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e) layers, superlattice-like structures with controlled dimensionality and spatially varying conduction band characteristics are demonstrated. This simple method is then explored for the fabrication of functional double-barrier resonant tunneling diodes. Nanoscale current mapping analysis using conductive atomic force microscopy reveals that resonant tunneling is not uniform but localized in specific regions of the apparent device area. The latter observation is attributed to variation in the layer(s) thickness of the In\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e quantum well and/or the Ga\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e barrier layers. Despite the nonidealities, the tremendous potential of solution-processable oxide semiconductors for the development of quantum effect devices that have so far been demonstrated only via sophisticated growth techniques is demonstrated.\u3c/p\u3

Randomized trial on fluorides and sealants for fissure caries prevention

To investigate the effectiveness of topical fluorides in preventing fissure caries, we conducted a randomized controlled trial with parallel groups. In total, 501 children (1,539 molars, 3,078 sites), mean age 9.1 years, who had at least one sound permanent first molar with deep fissures or fissures with signs of early caries were recruited. They were randomly allocated among four groups: (1) resin sealant, single placement; (2) 5% NaF varnish, semi-annual application; (3) 38% silver diamine fluoride (SDF) solution, annual application; and (4) placebo control. Follow-up examinations were conducted every 6 months by a masked examiner. After 24 months, 485 children (97%) were examined. Proportions of pit/fissure sites with dentin caries in the sealant, NaF, SDF, and control groups were 1.6%, 2.4%, 2.2%, and 4.6%, respectively. A multi-level logistic regression analysis accounting for the effects of data clustering and confounding factors showed that fissures in any of the three treatment groups had significantly lower risks of carious cavity development into dentin than did controls (p < 0.05). We concluded that placement of resin sealant, semi-annual application of NaF varnish, and annual application of SDF solution are all effective in preventing pit and fissure caries in permanent molars (ClinicalTrials.gov number CT01446107).postprin

Kinesthesia in a sustained-attention driving task

This study investigated the effects of kinesthetic stimuli on brain activities during a sustained-attention task in an immersive driving simulator. Tonic and phasic brain responses on multiple timescales were analyzed using time-frequency analysis of electroencephalographic (EEG) sources identified by independent component analysis (ICA). Sorting EEG spectra with respect to reaction times (RT) to randomly introduced lane-departure events revealed distinct effects of kinesthetic stimuli on the brain under different performance levels. Experimental results indicated that EEG spectral dynamics highly correlated with performance lapses when driving involved kinesthetic feedback. Furthermore, in the realistic environment involving both visual and kinesthetic feedback, a transitive relationship of power spectra between optimal-, suboptimal-, and poor-performance groups was found predominately across most of the independent components. In contrast to the static environment with visual input only, kinesthetic feedback reduced theta-power augmentation in the central and frontal components when preparing for action and error monitoring, while strengthening alpha suppression in the central component while steering the wheel. In terms of behavior, subjects tended to have a short response time to process unexpected events with the assistance of kinesthesia, yet only when their performance was optimal. Decrease in attentional demand, facilitated by kinesthetic feedback, eventually significantly increased the reaction time in the suboptimal-performance state. Neurophysiological evidence of mutual relationships between behavioral performance and neurocognition in complex task paradigms and experimental environments, presented in this study, might elucidate our understanding of distributed brain dynamics, supporting natural human cognition and complex coordinated, multi-joint naturalistic behavior, and lead to improved understanding of brain-behavior relations in operating environments. © 2014 Elsevier Inc

Electromagnetic design of a new hybrid-excited flux-switching machine for fault-tolerant operations

Paper no. YD-011541In this paper, a new hybrid-excited flux-switching (HEFS) machine is proposed with the outer-rotor configuration, which possesses the distinct feature of fault-tolerant operation. Comparing with the conventional permanent-magnet (PM) machine, it combines merits of flux control, high mechanical integrity, and low-cost. Furthermore, its fault-tolerant feature ensures its continuous operation in the event of winding faults. Hence, a new 12/10-pole HEFS machine is designed and implemented in this paper. By using time-stepping finite element method, open circuit (OC) fault and short circuit (SC) faults on the armature winding are investigated in the proposed machine for the fault-tolerant operation. The phase-current reconfiguration and flux control are applied for the remediation of the OC fault, while the SC faults is remedied by the phase-current reconfiguration merely. Both approaches demonstrate their good performances for the fault-tolerant operation. © 2015 IEEE.postprin

Prospective association between late-life physical activity and hospital care utilisation: a 7-year nationwide follow-up study

BACKGROUND: It is still equivocal whether there is a potential role of late-life physical activity in ameliorating the challenges of increasing healthcare expenditure due to the consequence of global population ageing. OBJECTIVE: this study aimed to examine the prospective association between physical activity and subsequent hospital care utilisation in older adults and to explore the optimal dose of physical activity required to reduce hospital care utilisation. DESIGN: this was a prospective cohort study based on the data from the Taiwan 2005 National Health Interview Survey, which were linked to the 2005-12 claims data from the National Health Insurance system. PARTICIPANTS: 1,760 older adults aged 65 or more. METHODS: the frequency, duration and intensity for physical activity were assessed, and total physical activity energy expenditure was estimated. The average annualised hospital care utilisation for the period 2006 through 2012, including number of hospitalisations, number of days in hospital and the costs of hospitalisation, were calculated. RESULTS: older adults engaging in at least moderate volume of physical activity (≥1,000 kcal/week) experienced fewer subsequent hospital admissions and fewer days in hospital than did sedentary individuals, after adjusting for covariates. Trends for reduced hospitalisation costs were also found. These associations persisted in sensitivity analyses, including tests of reverse causation. CONCLUSION: this study has provided evidence that older adults who are at least moderately active may minimise utilisation of hospital care services. The findings highlight the importance of maintaining a physically active lifestyle in later life

Caries control programme for children in China: one year results

Journal of Dental Research, 2001, v. 80 n. 4, p. 1377, abstract no. O-14published_or_final_versio