Cug2 is essential for normal mitotic control and CNS development in zebrafish.

Background: We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells. However, the in vivo function of CUG2 has not been studied in animal models. Results: To study the function of CUG2 in vivo, we isolated a zebrafish homologue that is expressed specifically in the proliferating cells of the central nervous system (CNS). Morpholino-mediated knockdown of cug2 resulted in apoptosis throughout the CNS and the development of neurodegenerative phenotypes. In addition, cug2-deficient embryos contained mitotically arrested cells displaying abnormal spindle formation and chromosome misalignment in the neural plate. Conclusions: Therefore, our findings suggest that Cug2 is required for normal mitosis during early neurogenesis and has functions in neuronal cell maintenance, thus demonstrating that the cug2 deficient embryos may provide a model system for human neurodegenerative disorders

Muon-spin-relaxation study of the magnetic penetration depth in MgB2

The magnetic vortex lattice (VL) of polycrystalline MgB2 has been investigated by transverse-field muon-spin-relaxation (TF-MuSR). The evolution of TF-MuSR depolarization rate, sigma, that is proportional to the second moment of the field distribution of the VL has been studied as a function of temperature and applied magnetic field. The low temperature value s exhibits a pronounced peak near Hext = 75 mT. This behavior is characteristic of strong pinning induced distortions of the VL which put into question the interpretation of the low-field TF-MuSR data in terms of the magnetic penetration depth lambda(T). An approximately constant value of sigma, such as expected for an ideal VL in the London-limit, is observed at higher fields of Hext > 0.4 T. The TF-MuSR data at Hext = 0.6 T are analyzed in terms of a two-gap model. We obtain values for the gap size of D1 = 6.0 meV (2D1/kBTc = 3.6), D2 = 2.6 meV (2D2/kBTc = 1.6), a comparable spectral weight of the two bands and a zero temperature value for the magnetic penetration depth of lambda = 100 nm. In addition, we performed MuSR-measurements in zero external field (ZF-MuSR). We obtain evidence that the muon site (at low temperature) is located on a ring surrounding the center of the boron hexagon. Muon diffusion sets in already at rather low temperature of T > 10 K. The nuclear magnetic moments can account for the observed relaxation rate and no evidence for electronic magnetic moments has been obtained.Comment: 15 pages, 4 figure

Resolving the M2-brane

We construct deformed, T^2 wrapped, rotating M2-branes on a resolved cone over Q^{1,1,1} and Q^{1,1,1}/Z_2, as well as on a product of two Eguchi-Hanson instantons. All worldvolume directions of these supersymmetric and regular solutions are fibred over the transverse space. These constitute gravity duals of D=3, N=2 gauge theories. In particular, the deformed M2-brane on a resolved cone over Q^{1,1,1} and the S^1 wrapped M2-brane on a resolved cone over Q^{1,1,1}/Z_2 provide explicit realizations of holographic renormalization group flows in M-theory for which both conformal and Lorentz symmetries are broken in the IR region and restored in the UV limit. These solutions can be dualized to supersymmetric type IIB pp-waves, which are rendered non-singular either by additional flux or a twisted time-like direction.Comment: Latex, 23 pages, references adde

Progress in neutrino oscillation searches and their implications

Neutrino Oscillation, in which a given flavour of neutrino transforms into another is a powerful tool for probing small neutrino masses. The intrinsic neutrino properties involved are neutrino mass squared difference $\Delta m^2$ and the mixing angle in vacuum $\theta$. In this talk I will summarize the progress that we have achieved in our search for neutrino oscillation with special emphasis on the recent results from the Sudbury Neutrino Observatory (SNO) on the measurement of solar neutrino fluxes. I will outline the current bounds on the neutrino masses and mixing parameters and discuss the major physics goals of future neutrino experiments in the context of the present picture.Comment: Plenary Talk, WHEPP-7, January 2002, published in Pramana, Vol. 60, 261, 200

Why Some Interfaces Cannot be Sharp

A central goal of modern materials physics and nanoscience is control of materials and their interfaces to atomic dimensions. For interfaces between polar and non-polar layers, this goal is thwarted by a polar catastrophe that forces an interfacial reconstruction. In traditional semiconductors this reconstruction is achieved by an atomic disordering and stoichiometry change at the interface, but in multivalent oxides a new option is available: if the electrons can move, the atoms don`t have to. Using atomic-scale electron energy loss spectroscopy we find that there is a fundamental asymmetry between ionically and electronically compensated interfaces, both in interfacial sharpness and carrier density. This suggests a general strategy to design sharp interfaces, remove interfacial screening charges, control the band offset, and hence dramatically improving the performance of oxide devices.Comment: 12 pages of text, 6 figure

Pseudogap formation of four-layer BaRuO3_3 and its electrodynamic response changes

We investiaged the optical properties of four-layer BaRuO$_{3}$, which shows a fermi-liquid-like behavior at low temperature. Its optical conductivity spectra clearly displayed the formation of a pseudogap and the development of a coherent peak with decreasing temperature. Temperature-dependences of the density $n$ and the scattering rate $1/\tau$ of the coherent component were also derived. As the temperature decreases, both $n$ and $1/\tau$ decrease for four-layer BaRuO$_{3}$. These electrodynamic responses were compared with those of nine-layer BaRuO$_{3}$, which also shows a pseudogap formation but has an insulator-like state at low temperature. It was found that the relative rates of change of both $n$ and $1/\tau$ determine either metallic or insulator-like responses in the ruthenates. The optical properties of the four-layer ruthenate were also compared with those of other pseudogap systems, such as high $T_{c}$ cuprates and heavy electron systems.Comment: 7 figures. submitted to Phys. Rev.

Carrier-mediated magnetoelectricity in complex oxide heterostructures

While tremendous success has been achieved to date in creating both single phase and composite magnetoelectric materials, the quintessential electric-field control of magnetism remains elusive. In this work, we demonstrate a linear magnetoelectric effect which arises from a novel carrier-mediated mechanism, and is a universal feature of the interface between a dielectric and a spin-polarized metal. Using first-principles density functional calculations, we illustrate this effect at the SrRuO$_3$/SrTiO$_3$ interface and describe its origin. To formally quantify the magnetic response of such an interface to an applied electric field, we introduce and define the concept of spin capacitance. In addition to its magnetoelectric and spin capacitive behavior, the interface displays a spatial coexistence of magnetism and dielectric polarization suggesting a route to a new type of interfacial multiferroic

Near-field examination of perovskite-based superlenses and superlens-enhanced probe-object coupling

A planar slab of negative index material works as a superlens with sub-diffraction-limited imaging resolution, since propagating waves are focused and, moreover, evanescent waves are reconstructed in the image plane. Here, we demonstrate a superlens for electric evanescent fields with low losses using perovskites in the mid-infrared regime. The combination of near-field microscopy with a tunable free-electron laser allows us to address precisely the polariton modes, which are critical for super-resolution imaging. We spectrally study the lateral and vertical distributions of evanescent waves around the image plane of such a lens, and achieve imaging resolution of wavelength/14 at the superlensing wavelength. Interestingly, at certain distances between the probe and sample surface, we observe a maximum of these evanescent fields. Comparisons with numerical simulations indicate that this maximum originates from an enhanced coupling between probe and object, which might be applicable for multifunctional circuits, infrared spectroscopy, and thermal sensors.Comment: 20 pages, 6 figures, published as open access article in Nature Communications (see http://www.nature.com/ncomms/