A CASE STUDY ON THE IMPLEMENTATION OF DISCIPLINARY LITERACY WITH MULTIMODAL DESIGN IN SOCIAL STUDIES

Social studies education provides education researchers with a less common opportunity to discover multimodal instructional methods for disciplinary literacy. During a 12-week period in 2021, four social studies teachers with at least one history course in a large suburban Mercer County, New Jersey school district participated in a case study to showcase how disciplinary literacy can be implemented using multimodal design. Given the existing lack of research on instructional literacy design for secondary grades, this study provides researchers and practitioners with multiple perspectives on how to maximize teaching practices in underrepresented areas of education. Significantly, social studies teachers will thus be able to build a highly effective set of disciplinary literacy activities that incorporate multimodalities, whether in a remote, hybrid, or traditional setting. The main research question for this study is: What are the experiences of teachers implementing disciplinary reading instruction using multimodality? In turn, the research sub-questions consider: How does the prior academic and/or professional background of participating social studies teachers influence the implementation of disciplinary literacy with multimodalities? To what extent are teachers reflecting on the effectiveness of the implementation of this practice? The instructional design for this study is based on Lave and Wenger’s (1991) situated learning: within the series of mini lessons, learned literacy takes place for students through participation while the whole person acts in the world. Participants were selected through purposive sampling in conjunction with the district’s central office administration. With the district looking to advance disciplinary literacy for all subjects over the next decade, the most collaborative-oriented social studies were selected, specifically either honors- or academic-level history courses. Through the case study, participant educators developed their understanding of how disciplinary literacy is attained for students, particularly through relationship-building and social practice. The overall findings highlight positive experiences from teachers after implementing a series of disciplinary literacy-focused mini-units with multimodalities. Since this study uses entirely qualitative methods, the data invites further analysis using different qualitative, quantitative, or mixed-method approaches to determine the best means to implement disciplinary literacy within history education, both during and after the Covid-19 pandemic

Comparative seismic performance of a moment frame equipped with Lateral Impact Resilient Double Concave Frictional devices

This study presents a comparative assessment of the seismic performance of a reinforced concrete moment frame equipped with a new isolator. The Lateral Impact Resilient Double Concave Friction Pendulum (LIR-DCFP) bearing has an enhanced inner slider capable of limiting the magnitude of the lateral impact force generated between the inner slider and the restraining rims of the sliding surfaces. Due to the presence of a plane high-friction interface with an internal gap, the novel isolator has an increased energy dissipation capacity that is activated during the lateral impact. Three isolation systems were considered to evaluate the benefits of using LIR-DCFP devices. One conformed by the suggested isolator, and two composed of classic non-articulated Double Concave Friction Pendulum (DCFP) bearings. The isolation devices were modelled employing a numerical formulation based on rigid body dynamics, capable of accounting for the lateral impact behaviour. The superstructure, a reinforced concrete moment resisting frame designed according to the American ASCE/SEI 7-16 standard, was modelled using beam-column elements considering geometric and material nonlinearities. Furthermore, the degrading behaviour of the building was incorporated using a proper degradation model for both the stiffness and the force. Incremental Dynamic Analyses (IDAs) were performed considering the friction coefficient as a random variable to characterize the statistics of the maximum inter-story responses. With the data generated in the IDAs, fragility curves related to the superstructure performance were constructed. Finally, employing the hazard curve, reliability curves were derived. The superstructure equipped with LIR-DCFP bearings presents better seismic performance than the same building equipped with the same size DCFP isolators. The benefits of using the new isolator are not achieved by increasing the lateral capacity of the classic isolation system

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy

It is generally believed that increase in adult contractile cardiac mass can be accomplished only by hypertrophy of existing myocytes. Documentation of myocardial regeneration in acute stress has challenged this dogma and led to the proposition that myocyte renewal is fundamental to cardiac homeostasis. Here we report that in human aortic stenosis, increased cardiac mass results from a combination of myocyte hypertrophy and hyperplasia. Intense new myocyte formation results from the differentiation of stem-like cells committed to the myocyte lineage. These cells express stem cell markers and telomerase. Their number increased >13-fold in aortic stenosis. The finding of cell clusters with stem cells making the transition to cardiogenic and myocyte precursors, as well as very primitive myocytes that turn into terminally differentiated myocytes, provides a link between cardiac stem cells and myocyte differentiation. Growth and differentiation of these primitive cells was markedly enhanced in hypertrophy, consistent with activation of a restricted number of stem cells that, through symmetrical cell division, generate asynchronously differentiating progeny. These clusters strongly support the existence of cardiac stem cells that amplify and commit to the myocyte lineage in response to increased workload. Their presence is consistent with the notion that myocyte hyperplasia significantly contributes to cardiac hypertrophy and accounts for the subpopulation of cycling myocytes

STATIC AND DYNAMIC EXPERIMENTAL VALIDATIONS OF THE LATERAL IMPACT RESILIENT DOUBLE CONCAVE FRICTION PENDULUM (LIR-DCFP) BEARING

During high-magnitude earthquakes, large base displacements that exceed the lateral capacity of the isolation level can cause internal impacts jeopardizing the benefits of using seismic isolation. The Lateral Impact Resilient Double Concave Friction Pendulum (LIR-DCFP) bearing has been proposed to mitigate the adverse effects of internal lateral impacts between inner sliders and restraining rims of sliding surfaces. This device has an enhanced inner slider formed by two bodies. These bodies are in contact, generating a plane high-friction interface capable of dissipating additional energy and limiting the magnitude of the impact. A numerical model based on rigid body dynamics has been proposed to represent the dynamic response of structures equipped with LIR-DCFP bearings. The numerical formulation includes important modeling aspects such as lateral impact behavior and large displacements (P-? effects), among other essential phenomena. A prototype of this novel device was constructed to validate its lateral behavior through static experimental tests. As predicted, if the inner slider does not contact the restraining rims of the sliding surfaces, the response of the isolator will be identical to the response of the classical frictional isolators. On the contrary, for larger lateral displacements, the contact between the inner slider and the restraining rims triggers high friction sliding. Finally, experimental tests were conducted to validate the dynamic response of a stiff structure equipped with four LIR-DCFP devices. An accurate prediction of the dynamic response can be obtained by employing the suggested numerical model under the presence or absence of internal lateral impacts

Target analysis and retrospective screening of multiple mycotoxins in pet food using UHPLC-Q-Orbitrap HRMS

A comprehensive strategy combining a quantitative method for 28 mycotoxins and a post-target screening for other 245 fungal and bacterial metabolites in dry pet food samples were developed using an acetonitrile-based extraction and an ultrahigh-performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) method. The proposed method showed satisfactory validation results according to Commission Decision 2002/657/EC. Average recoveries from 72 to 108% were obtained for all studied mycotoxins, and the intra-/inter-day precision were below 9 and 14%, respectively. Results showed mycotoxin contamination in 99% of pet food samples (n = 89) at concentrations of up to hundreds µg/kg, with emerging Fusarium mycotoxins being the most commonly detected mycotoxins. All positive samples showed co-occurrence of mycotoxins with the simultaneous presence of up to 16 analytes per sample. In the retrospective screening, up to 54 fungal metabolites were tentatively identified being cyclopiazonic acid, paspalitrem A, fusaric acid, and macrosporin, the most commonly detected analytes

Ex vivo model predicted in vivo efficacy of CFTR modulator therapy in a child with rare genotype

Background: New drugs that target the basic defect in cystic fibrosis (CF) patients may now be used in a large number of patients carrying responsive mutations. Nevertheless, further research is needed to extend the benefit of these treatments to patients with rare mutations that are still uncharacterized in vitro and that are not included in clinical trials. For this purpose, ex vivo models are necessary to preliminary assessing the effect of CFTR modulators in these cases. Method: We report the clinical effectiveness of lumacaftor/ivacaftor therapy prescribed to a CF child with a rare genetic profile (p.Phe508del/p.Gly970Asp) after testing the drug on nasal epithelial cells. We observed a significant drop of the sweat chloride value, as of the lung clearance index. A longer follow-up period is needed to define the effects of therapy on pancreatic status, although an increase of the fecal elastase values was found. Conclusion: Drug response obtained on nasal epithelial cells correlates with changes in vivo therapeutic endpoints and can be a predictor of clinical efficacy of novel drugs especially in pediatric patients

Activity and Process Stability of Purified Green Pepper (Capsicum annuum) Pectin Methylesterase

Pectin methylesterase (PME) from green bell peppers (Capsicum annuum) was extracted and purified by affinity chromatography on a CNBr-Sepharose-PMEI column. A single protein peak with pectin methylesterase activity was observed. For the pepper PME, a biochemical characterization in terms of molar mass (MM), isoelectric points (pI), and kinetic parameters for activity and thermostability was performed. The optimum pH for PME activity at 22 °C was 7.5, and its optimum temperature at neutral pH was between 52.5 and 55.0 °C. The purified pepper PME required the presence of 0.13 M NaCl for optimum activity. Isothermal inactivation of purified pepper PME in 20 mM Tris buffer (pH 7.5) could be described by a fractional conversion model for lower temperatures (55?57 °C) and a biphasic model for higher temperatures (58?70 °C). The enzyme showed a stable behavior toward high-pressure/temperature treatments. Keywords: Capsicum annuum; pepper; pectin methylesterase; purification; characterization; thermal and high-pressure stabilit

Yukawa potentials in systems with partial periodic boundary conditions I : Ewald sums for quasi-two dimensional systems

Yukawa potentials are often used as effective potentials for systems as colloids, plasmas, etc. When the Debye screening length is large, the Yukawa potential tends to the non-screened Coulomb potential ; in this small screening limit, or Coulomb limit, the potential is long ranged. As it is well known in computer simulation, a simple truncation of the long ranged potential and the minimum image convention are insufficient to obtain accurate numerical data on systems. The Ewald method for bulk systems, i.e. with periodic boundary conditions in all three directions of the space, has already been derived for Yukawa potential [cf. Y., Rosenfeld, {\it Mol. Phys.}, \bm{88}, 1357, (1996) and G., Salin and J.-M., Caillol, {\it J. Chem. Phys.}, \bm{113}, 10459, (2000)], but for systems with partial periodic boundary conditions, the Ewald sums have only recently been obtained [M., Mazars, {\it J. Chem. Phys.}, {\bf 126}, 056101 (2007)]. In this paper, we provide a closed derivation of the Ewald sums for Yukawa potentials in systems with periodic boundary conditions in only two directions and for any value of the Debye length. A special attention is paid to the Coulomb limit and its relation with the electroneutrality of systems.Comment: 40 pages, 5 figures and 4 table

The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache

BACKGROUND: A better understanding of potential relationship between mood disorders, sleep quality, pain, and headache frequency may assist clinicians in determining optimal therapeutic programs. The aim of the current study was to analyze the effects of sleep quality, anxiety, depression on potential relationships between headache intensity, burden of headache, and headache frequency in chronic tension type headache (CTTH). METHODS: One hundred and ninety-three individuals with CTTH participated. Headache features were collected with a 4-weeks headache diary. The Hospital Anxiety and Depression Scale was used for assessing anxiety and depression. Headache Disability Inventory evaluated the burden of headache. Pain interference was determined with the bodily pain domain (SF-36 questionnaire). Sleep quality was assessed with Pittsburgh Sleep Quality Index. Path analyses with maximum likelihood estimations were conducted to determine the direct and indirect effects of depression, anxiety, and sleep quality on the frequency of headaches. RESULT: Two paths were observed: the first with depression and the second with sleep quality as mediators. Direct effects were noted from sleep quality, emotional burden of disease and pain interference on depression, and from depression to headache frequency. The first path showed indirect effects of depression from emotional burden and from sleep quality to headache frequency (first model R (2) = 0.12). Direct effects from the second path were from depression and pain interference on sleep quality and from sleep quality on headache frequency. Sleep quality indirectly mediated the effects of depression, emotional burden and pain interference on headache frequency (second model R (2) = 0.18). CONCLUSIONS: Depression and sleep quality, but not anxiety, mediated the relationship between headache frequency and the emotional burden of disease and pain interference in CTTH