Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number. Leveraging the multi-platform data, we observed that ARID1A exhibited DNA hypermethylation and decreased expression in the IDH mutant subtype. More broadly, we found that IDH mutations are associated with an expanded histological spectrum of liver tumors with molecular features that stratify with CCA. Our studies reveal insights into the molecular pathogenesis and heterogeneity of cholangiocarcinoma and provide classification information of potential therapeutic significance

Estimation of illegal slave trade to Pernambuco in the first half of the 19th century.

Estimation of illegal slave trade to Pernambuco in the first half of the 19th century

THE ATLANTIC MATA: SERTÕES DE PERNAMBUCO AND ALAGOAS, SÉCS. XVII-XIX.

The forests between Alagoas and Pernambuco sheltered the quilombolas and Indians that participated in both the epic of Palmares and the Cabanada (1832-35). The so-called "people of the woods" consisted of communities whose relations to each other were contradictory and complex. The forests where they lived survived through the colonial period because of their relevance to the sugar industry and to the economy as a whole

A MATA ATLÂNTICA: SERTÕES DE PERNAMBUCO E ALAGOAS, SÉCS. XVII-XIX.

As matas entre Alagoas e Pernambuco abrigaram os quilombolas e índios que participaram tanto da epopéia de Palmares quanto da Cabanada (1832-35). A chamada "gente das matas" era constituída de comunidades cujas relações entre si eram contraditórias e complexas. As florestas onde viviam sobreviveram, atravessando o período colonial devido à sua relevância para a indústria açucareira e para a economia como um todo.

O ENCONTRO DA "SOLDADESCA DESENFREADA" COM OS "CIDADÃOS DE COR MAIS LEVIANOS" NO RECIFE EM 1831.

Este trabalho busca atenter as motivações e o significado da Quartelada no Recife, mais conhecida como Setembrizada.

Estimativa do tráfico ilegal de escravos para Pernambuco, na primeira metade do Século XIX.

Estimativa do tráfico ilegal de escravos para Pernambuco, na primeira metade do Século XIX

APRESENTAÇÃO

APRESENTAÇÃ