STUDY OF THE O-18+Ni-64 TWO-NEUTRON TRANSFER REACTION AT 84 MeV BY MAGNEX

A study of the two-neutron transfer reaction of the O-18 + Ni-64 system at 84 MeV incident energy to the ground and first 2(+) excited state of the residual Ni-66 nucleus is presented. The experiment was performed at the INFN-LNS (Italy) by using the large acceptance MAGNEX spectrometer. Theoretical models are used in order to disentangle the competition between long-range and short-range correlations

Long-range versus short-range correlations in the two-neutron transfer reaction Ni 64 (O 18, O 16) Ni 66

Recently, various two-neutron transfer studies using the (18O,16O) reaction were performed with a large success. This was achieved because of a combined use of the microscopic quantum description of the reaction mechanism and of the nuclear structure. In the present work we use this methodology to study the two-neutron transfer reaction of the 18O+64Ni system at 84 MeV incident energy, to the ground and first 2+ excited state of the residual 66Ni nucleus. All the experimental data were measured by the large acceptance MAGNEX spectrometer at the Instituto Nazionale di Fisica Nucleare \u2013Laboratori Nazionali del Sud (Italy). We have performed exact finite range cross section calculations using the coupled channel Born approximation (CCBA) and coupled reaction channel (CRC) method for the sequential and direct two-neutron transfers, respectively. Moreover, this is the first time that the formalism of the microscopic interaction boson model (IBM-2) was applied to a two-neutron transfer reaction. From our results we conclude that for two-neutron transfer to the ground state of 66Ni, the direct transfer is the dominant reaction mechanism, whereas for the transfer to the first excited state of 66Ni, the sequential process dominates. A competition between long-range and short-range correlations is discussed, in particular, how the use of two different models (Shell model and IBM's) help to disentangle long- and short-range correlations

La Biblioteca Digital de la Arquidiócesis de Mérida (Venezuela) y el modelo de metadatos: una propuesta para la difusión de los bienes culturales de la Iglesia Católica en la web

The Digital Library of the Mérida’s Archdiocese in Venezuela will incorporate for its diffusion all of the cultural heritage of the Church in this region. The proposal is developed in two stages. First, defining a data/metadata model that allows describing all of the different items and relations established among them. The objective of this stage is to guarantee the contextual conservation of the cultural heritage of the Mérida’s Archdiocese, and to propose the use metadata standards that assure the interoperability of the Digital Library and assure the access, in the future, to the information and knowledge of the cultural belongings of the Venezuelan Church that are in both digital and no digital formats. The second stage will consist in selecting and classifying the services that the Church will provide to its community, depending on particular relations (i. e. Government, private organizations, education and research), as well as the design of the graphical interface that concur with the image of the Church, the selection and adaptation of the technological infrastructure, and the preservation and diffusion of the Church’s patrimony.La Biblioteca Digital de la Arquidiócesis de Mérida (Venezuela) incorporará para su difusión todos los bienes culturales de la Iglesia merideña. La propuesta se desarrolla en dos grandes etapas. La primera, la definición del modelo de datos/metadatos que permita describir los diferentes bienes y las relaciones establecidas entre ellos. El objetivo es garantizar la conservación contextual del patrimonio cultural, en este caso de la Arquidiócesis de Mérida, y proponer el uso de estándares de metadatos que garanticen la interoperabilidad de la Biblioteca Digital y aseguren el acceso, en el futuro, a la información y al conocimiento de los bienes culturales de la Iglesia venezolana que se encuentran en formato digital y no digital. En la siguiente etapa se abordará la clasificación de los servicios que se prestarán, enmarcados en la relación que tiene la Iglesia con su comunidad (Gobierno, organizaciones privadas, sector educativo y de investigación), así como el diseño de la interfaz gráfica acorde con la imagen de la Iglesia, la selección y adaptación de la infraestructura tecnológica y, la preservación y difusión de los bienes de la Iglesi

Outbreak Of NDM-1-producing Klebsiella Pneumoniae In A Neonatal Unit In Colombia

Six multiresistant, NDM-1-producing Klebsiella pneumoniae strains were recovered from an outbreak that affected six neonatal patients in a Colombian hospital. Molecular analysis showed that all of the isolates harbored the blaNDM-1, qnrA, and intI1 genes and were clonally related. Multilocus sequence typing showed that the isolates belonged to a new sequence type (ST1043) that was different from the sequence types that had previously been reported. This is the first report of NDM-1-producing isolates in South America

Elastic scattering measurements for the 10C + 208Pb system at Elab = 66 MeV

Background: The influence of halo structure of 6 He, 8 B, 11Be, and 11Li nuclei in several mechanisms such as direct reactions and fusion is already established, although not completely understood. The influence of the 10C Brunnian structure is less known. Purpose: To investigate the influence of the cluster configuration of 10C on the elastic scattering at an energy close to the Coulomb barrier. Methods: We present experimental data for the elastic scattering of the 10C + 208Pb system at Elab = 66 MeV. The data are compared to the three- and the four-body continuum-discretized coupled-channels calculations assuming 9 B +p, 6 Be +α, and 8 Be +p + p configurations. Results: The experimental angular distribution of the cross sections shows the suppression of the Fresnel peak that is reasonably well reproduced by the continuum-discretized coupled-channels calculations. However, the calculations underestimate the cross sections at backward angles. Couplings to continuum states represent a small effect. Conclusions: The cluster configurations of 10C assumed in the present work are able to describe some of the features of the data. To explain the data at backward angles, experimental data for the breakup and an extension of theoretical formalism towards a four-body cluster seem to be in need to reproduce the measured angular distribution.Ministerio de España de Economía y Competitividad, el Foro Regional Europeo Fondo de Desarrollo (FEDER) FIS2017- 88410-PPrograma Horizonte 2020 de la Unión Europea Subvención No. 654002Fondos SID 2019 (Università degli Studi di Padova, Italia) CASA_SID19_01

Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder

<p>Abstract</p> <p>Background</p> <p>Fesoterodine is an antimuscarinic for the treatment of overactive bladder, a syndrome of urgency, with or without urgency urinary incontinence (UUI), usually with increased daytime frequency and nocturia. Our objective was to develop predictive models to describe the dose response of fesoterodine.</p> <p>Methods</p> <p>Data from subjects enrolled in double-blind, placebo-controlled phase II and III trials were used for developing longitudinal dose-response models.</p> <p>Results</p> <p>The models predicted that clinically significant and near-maximum treatment effects would be seen within 3 to 4 weeks after treatment initiation. For a typical patient with 11 micturitions per 24 hours at baseline, predicted change was -1.2, -1.7, and -2.2 micturitions for placebo and fesoterodine 4 mg and 8 mg, respectively. For a typical patient with 2 UUI episodes per 24 hours at baseline, predicted change was -1.05, -1.26, and -1.43 UUI episodes for placebo and fesoterodine 4 mg and 8 mg, respectively. Increase in mean voided volume was estimated at 9.7 mL for placebo, with an additional 14.2 mL and 28.4 mL for fesoterodine 4 mg and 8 mg, respectively.</p> <p>Conclusions</p> <p>A consistent dose response for fesoterodine was demonstrated for bladder diary endpoints in subjects with overactive bladder, a result that supports the greater efficacy seen with fesoterodine 8 mg in post hoc analyses of clinical trial data. The dose-response models can be used to predict outcomes for doses not studied or for patient subgroups underrepresented in clinical trials.</p> <p>Trial Registration</p> <p>The phase III trials used in this analysis have been registered at ClinicalTrials.gov (NCT00220363 and NCT00138723).</p

Exclusive neuronal expression of SUCLA2 in the human brain

SUCLA2 encodes the ATP-forming subunit (A-SUCL-) of succinyl-CoA ligase, an enzyme of the citric acid cycle. Mutations in SUCLA2 lead to a mitochondrial disorder manifesting as encephalomyopathy with dystonia, deafness and lesions in the basal ganglia. Despite the distinct brain pathology associated with SUCLA2 mutations, the precise localization of SUCLA2 protein has never been investigated. Here we show that immunoreactivity of A-SUCL- in surgical human cortical tissue samples was present exclusively in neurons, identified by their morphology and visualized by double labeling with a fluorescent Nissl dye. A-SUCL- immunoreactivity co-localized >99% with that of the d subunit of the mitochondrial F0-F1 ATP synthase. Specificity of the anti-A-SUCL- antiserum was verified by the absence of labeling in fibroblasts from a patient with a complete deletion of SUCLA2. A-SUCL- immunoreactivity was absent in glial cells, identified by antibodies directed against the glial markers GFAP and S100. Furthermore, in situ hybridization histochemistry demonstrated that SUCLA2 mRNA was present in Nissl-labeled neurons but not glial cells labeled with S100. Immunoreactivity of the GTP-forming subunit (G-SUCL-) encoded by SUCLG2, or in situ hybridization histochemistry for SUCLG2 mRNA could not be demonstrated in either neurons or astrocytes. Western blotting of post mortem brain samples revealed minor G-SUCL- immunoreactivity that was however, not upregulated in samples obtained from diabetic versus non-diabetic patients, as has been described for murine brain. Our work establishes that SUCLA2 is expressed exclusively in neurons in the human cerebral cortex